Abstract
Cardiovascular system exhibits various responses to mechanical stimulations. Overload in heart induces arrhythmias or hypertrophy. Increases in blood flow or blood pressure elicit vessel dilation via an activation of endothelial cells. Although the molecular mechanism of these responses are unclear, the evidence has been accumulated that the stretch activated (SA) ion channel acts as a primary sensor for mechanical stimuli. In this article, cardiovascular responses to mechanical stimuli have been summarized and the possible role of SA channels is discussed.
Original language | English |
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Pages (from-to) | 1891-1898 |
Number of pages | 8 |
Journal | Nippon rinsho. Japanese journal of clinical medicine |
Volume | 51 |
Issue number | 7 |
Publication status | Published - Jul 1993 |
Externally published | Yes |
ASJC Scopus subject areas
- Medicine(all)