Abstract
We investigated the possible contribution of inducible nitric oxide synthase (inos) to postischemic heart dysfunction and injuries in stroke-prone spontaneously hypertensive rats (shrsp). Shrsp, 13-14 wk of age, had significantly higher systolic blood pressure and greater heart weight than age-matched Wistar-Kyoto rats (WKY). Permanent occlusion of the left anterior descending coronary artery (LAD) caused significant and long-lasting increases in the activity and mRNA expression of myocardial iNOS in SHRSP compared with WKY. However, there was no significant difference in the LAD occlusion-induced expression of interleukin-1β mRNA between SHRSP and WKY. Hemodynamic deterioration and myocardial fibrosis were also observed in SHRSP at 4 wk after LAD occlusion. Continuous administration of 2-amino-5,6-dihydro-6-methyl-4H-1,2-thiazin (AMT) completely blocked the LAD occlusion-induced increase in the myocardial iNOS activity of SHRSP. Moreover, postischemic heart dysfunction and injuries were also significantly ameliorated by 2-amino-5,6-dihydro-6-methyl-4H-1,2-thiazin (AMT). These results suggest that the increased activity of myocardial iNOS plays a pivotal role in the development of postischemic cardiac dysfunction and injuries in SHRSP with the hypertensive and hypertrophic heart.
Original language | English |
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Pages (from-to) | H668-H673 |
Journal | American Journal of Physiology - Heart and Circulatory Physiology |
Volume | 280 |
Issue number | 2 49-2 |
DOIs | |
Publication status | Published - Feb 2001 |
Externally published | Yes |
Keywords
- 2-amino-5,6-dihydro-6-methyl-4H-1,2-thiazin
- Cardiac hypertrophy
- Left anterior descending coronary artery occlusion
ASJC Scopus subject areas
- Physiology
- Cardiology and Cardiovascular Medicine
- Physiology (medical)