Involvement of hedgehog, wingless, and dpp in the initiation of proximodistal axis formation during the regeneration of insect legs, a verification of the modified boundary model

Taro Mito, Yoshiko Inoue, Shinsuke Kimura, Katsuyuki Miyawaki, Nao Niwa, Yohei Shinmyo, Hideyo Ohuchi, Sumihare Noji

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42 Citations (Scopus)

Abstract

To understand the mechanism of regeneration, many experiments have been carried out with hemimetabolous insects, since their nymphs possess the ability to regenerate amputated legs. We first succeeded in observing expression patterns of hedgehog, wingless (wg), and decapentaplegic (dpp) during leg regeneration of the cricket Gryllus bimaculatus. The observed expression patterns were essentially consistent with the predictions derived from the boundary model modified by Campbell and Tomlinson (CTBM). Thus, we concluded that the formation of the proximodistal axis of a regenerating leg is triggered at a site where ventral wg-expressing cells abut dorsal dpp-expressing cells in the anteroposterior (A/P) boundary, as postulated in the CTBM.

Original languageEnglish
Pages (from-to)27-35
Number of pages9
JournalMechanisms of Development
Volume114
Issue number1-2
DOIs
Publication statusPublished - May 13 2002
Externally publishedYes

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Keywords

  • Boundary model
  • Cricket
  • Insect
  • Leg
  • Proximodistal axis
  • Regeneration

ASJC Scopus subject areas

  • Embryology
  • Developmental Biology

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