Abstract
Vertebrate limb morphogenesis has been investigated as a model system of pattern formation. Recent results suggest that peptide growth factors are involved in the limb morphogenesis. Members of the fibroblast growth factor family stimulate proliferation of the limb mesenchymal cells, while members of the transforming growth factor (TGF)-β family, in contrast, inhibit the proliferation. The antagonistic effect between the two families is probably essential for establishment of both anteroposterior and proximodistal axes. The Wnt and TGF-β families may be related to morphogenesis of the dorsoventral axis. The three families are also involved in chondrogenesis, osteogenesis, and feather formation. In this review, possible roles of such growth factors and their receptors in morphogenesis of the limb are discussed.
| Original language | English |
|---|---|
| Pages (from-to) | 79-90 |
| Number of pages | 12 |
| Journal | Gann Monographs on Cancer Research |
| Volume | 42 |
| Publication status | Published - 1994 |
| Externally published | Yes |
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ASJC Scopus subject areas
- Cancer Research
Cite this
Involvement of growth factors and their receptors in morphogenesis of the chick limb. / Nohno, T.; Ohuchi, Hideyo; Yoshioka, H.; Noji, S.
In: Gann Monographs on Cancer Research, Vol. 42, 1994, p. 79-90.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Involvement of growth factors and their receptors in morphogenesis of the chick limb
AU - Nohno, T.
AU - Ohuchi, Hideyo
AU - Yoshioka, H.
AU - Noji, S.
PY - 1994
Y1 - 1994
N2 - Vertebrate limb morphogenesis has been investigated as a model system of pattern formation. Recent results suggest that peptide growth factors are involved in the limb morphogenesis. Members of the fibroblast growth factor family stimulate proliferation of the limb mesenchymal cells, while members of the transforming growth factor (TGF)-β family, in contrast, inhibit the proliferation. The antagonistic effect between the two families is probably essential for establishment of both anteroposterior and proximodistal axes. The Wnt and TGF-β families may be related to morphogenesis of the dorsoventral axis. The three families are also involved in chondrogenesis, osteogenesis, and feather formation. In this review, possible roles of such growth factors and their receptors in morphogenesis of the limb are discussed.
AB - Vertebrate limb morphogenesis has been investigated as a model system of pattern formation. Recent results suggest that peptide growth factors are involved in the limb morphogenesis. Members of the fibroblast growth factor family stimulate proliferation of the limb mesenchymal cells, while members of the transforming growth factor (TGF)-β family, in contrast, inhibit the proliferation. The antagonistic effect between the two families is probably essential for establishment of both anteroposterior and proximodistal axes. The Wnt and TGF-β families may be related to morphogenesis of the dorsoventral axis. The three families are also involved in chondrogenesis, osteogenesis, and feather formation. In this review, possible roles of such growth factors and their receptors in morphogenesis of the limb are discussed.
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M3 - Article
VL - 42
SP - 79
EP - 90
JO - Gann Monographs on Cancer Research
JF - Gann Monographs on Cancer Research
SN - 0072-0151
ER -