Involvement of growth factors and their receptors in morphogenesis of the chick limb

T. Nohno, Hideyo Ohuchi, H. Yoshioka, S. Noji

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Vertebrate limb morphogenesis has been investigated as a model system of pattern formation. Recent results suggest that peptide growth factors are involved in the limb morphogenesis. Members of the fibroblast growth factor family stimulate proliferation of the limb mesenchymal cells, while members of the transforming growth factor (TGF)-β family, in contrast, inhibit the proliferation. The antagonistic effect between the two families is probably essential for establishment of both anteroposterior and proximodistal axes. The Wnt and TGF-β families may be related to morphogenesis of the dorsoventral axis. The three families are also involved in chondrogenesis, osteogenesis, and feather formation. In this review, possible roles of such growth factors and their receptors in morphogenesis of the limb are discussed.

Original languageEnglish
Pages (from-to)79-90
Number of pages12
JournalGann Monographs on Cancer Research
Volume42
Publication statusPublished - 1994
Externally publishedYes

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Growth Factor Receptors
Morphogenesis
Extremities
Transforming Growth Factors
Chondrogenesis
Feathers
Fibroblast Growth Factors
Osteogenesis
Vertebrates
Intercellular Signaling Peptides and Proteins
Peptides

ASJC Scopus subject areas

  • Cancer Research

Cite this

Involvement of growth factors and their receptors in morphogenesis of the chick limb. / Nohno, T.; Ohuchi, Hideyo; Yoshioka, H.; Noji, S.

In: Gann Monographs on Cancer Research, Vol. 42, 1994, p. 79-90.

Research output: Contribution to journalArticle

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