Abstract
Morphine (5 mg/kg, s.c.) caused a submaximal increase in the brain level of sodium fluorescein administered i.v. Histamine H1-antagonists, diphenhydramine and mepyramine, given either i.p. or i.c.v., had no significant influence on the effect of morphine. H2-Antagonists, cimetidine and ranitidine, administered i.c.v., but not i.p., significantly inhibited the morphine effect. α-Fluoromethylhistidine, a specific histidine decarboxylase inhibitor (given i.p. and i.e.v.) and antimuscarinic drugs, atropine and biperiden, but not methylatropine (given i.p.) also significantly reduced the morphine effect. Physostigmine (i.p.) significantly enhanced the effects of 0.5 and 1 mg/kg of morphine. Similar effects of histaminergic and cholinergic drugs were also observed on the buprenorphine- and DAGO-induced increase in blood-brain barrier (BBB) permeability to sodium fluorescein. None of the treatments with 6-hydroxydopamine, α-methylayrosine, 5,7-dihydroxytryptamine or p-chlorophenylamine had any significant effect on the morphine-induced increase in BBB permeability. These findings suggest that the activation of brain H2-receptors by neuronal histamine and muscarinic receptors by acetylcholine is involved in the increase in BBB permeability to sodium fluorescein caused by μ opioid receptor agonists.
| Original language | English |
|---|---|
| Pages (from-to) | 159-165 |
| Number of pages | 7 |
| Journal | Naunyn-Schmiedeberg's Archives of Pharmacology |
| Volume | 339 |
| Issue number | 1 |
| DOIs | |
| Publication status | Published - 1989 |
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Keywords
- Blood-brain-barrier
- H-Receptors
- Histamine
- Morphine
- Sodium fluorescein
ASJC Scopus subject areas
- Pharmacology
Cite this
Involvement of central histaminergic and cholinergic systems in the morphine-induced increase in blood-brain barrier permeability to sodium fluorescein in mice. / Oishi, Ryozo; Baba, Miwa; Nishibori, Masahiro; Itoh, Yoshinori; Saeki, Kiyomi.
In: Naunyn-Schmiedeberg's Archives of Pharmacology, Vol. 339, No. 1, 1989, p. 159-165.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Involvement of central histaminergic and cholinergic systems in the morphine-induced increase in blood-brain barrier permeability to sodium fluorescein in mice
AU - Oishi, Ryozo
AU - Baba, Miwa
AU - Nishibori, Masahiro
AU - Itoh, Yoshinori
AU - Saeki, Kiyomi
PY - 1989
Y1 - 1989
N2 - Morphine (5 mg/kg, s.c.) caused a submaximal increase in the brain level of sodium fluorescein administered i.v. Histamine H1-antagonists, diphenhydramine and mepyramine, given either i.p. or i.c.v., had no significant influence on the effect of morphine. H2-Antagonists, cimetidine and ranitidine, administered i.c.v., but not i.p., significantly inhibited the morphine effect. α-Fluoromethylhistidine, a specific histidine decarboxylase inhibitor (given i.p. and i.e.v.) and antimuscarinic drugs, atropine and biperiden, but not methylatropine (given i.p.) also significantly reduced the morphine effect. Physostigmine (i.p.) significantly enhanced the effects of 0.5 and 1 mg/kg of morphine. Similar effects of histaminergic and cholinergic drugs were also observed on the buprenorphine- and DAGO-induced increase in blood-brain barrier (BBB) permeability to sodium fluorescein. None of the treatments with 6-hydroxydopamine, α-methylayrosine, 5,7-dihydroxytryptamine or p-chlorophenylamine had any significant effect on the morphine-induced increase in BBB permeability. These findings suggest that the activation of brain H2-receptors by neuronal histamine and muscarinic receptors by acetylcholine is involved in the increase in BBB permeability to sodium fluorescein caused by μ opioid receptor agonists.
AB - Morphine (5 mg/kg, s.c.) caused a submaximal increase in the brain level of sodium fluorescein administered i.v. Histamine H1-antagonists, diphenhydramine and mepyramine, given either i.p. or i.c.v., had no significant influence on the effect of morphine. H2-Antagonists, cimetidine and ranitidine, administered i.c.v., but not i.p., significantly inhibited the morphine effect. α-Fluoromethylhistidine, a specific histidine decarboxylase inhibitor (given i.p. and i.e.v.) and antimuscarinic drugs, atropine and biperiden, but not methylatropine (given i.p.) also significantly reduced the morphine effect. Physostigmine (i.p.) significantly enhanced the effects of 0.5 and 1 mg/kg of morphine. Similar effects of histaminergic and cholinergic drugs were also observed on the buprenorphine- and DAGO-induced increase in blood-brain barrier (BBB) permeability to sodium fluorescein. None of the treatments with 6-hydroxydopamine, α-methylayrosine, 5,7-dihydroxytryptamine or p-chlorophenylamine had any significant effect on the morphine-induced increase in BBB permeability. These findings suggest that the activation of brain H2-receptors by neuronal histamine and muscarinic receptors by acetylcholine is involved in the increase in BBB permeability to sodium fluorescein caused by μ opioid receptor agonists.
KW - Blood-brain-barrier
KW - H-Receptors
KW - Histamine
KW - Morphine
KW - Sodium fluorescein
UR - http://www.scopus.com/inward/record.url?scp=0024533091&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0024533091&partnerID=8YFLogxK
U2 - 10.1007/BF00165138
DO - 10.1007/BF00165138
M3 - Article
C2 - 2566923
AN - SCOPUS:0024533091
VL - 339
SP - 159
EP - 165
JO - Naunyn-Schmiedeberg's Archives of Pharmacology
JF - Naunyn-Schmiedeberg's Archives of Pharmacology
SN - 0028-1298
IS - 1
ER -