Involvement of Ca2+-calmodulin-dependent protein kinase II in the intestinal secretory action of Escherichia coli heat-stable enterotoxin II

Yoshio Fujii, Tomohiko Nomura, Hiroyasu Yamanaka, Keinosuke Okamoto

Research output: Contribution to journalArticlepeer-review

22 Citations (Scopus)

Abstract

Treating the mouse intestine with the calmodulin antagonist W-7 and KN- 93, an inhibitor of Ca2+-calmodulin-dependent protein kinase II (CaMK II), reduced the sensitivity of the host to the action of Escherichia coli heat- stable enterotoxin II (STII). CaMK II activity in mouse intestinal cells increased after exposure to STII. These results indicate that CaMK II is involved in the mechanism of action of STII.

Original languageEnglish
Pages (from-to)633-636
Number of pages4
JournalMICROBIOLOGY and IMMUNOLOGY
Volume41
Issue number8
DOIs
Publication statusPublished - 1997
Externally publishedYes

Keywords

  • Calmodulin
  • Enterotoxin
  • Escherichia coli

ASJC Scopus subject areas

  • Microbiology
  • Immunology
  • Virology

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