Involvement of calmodulin-dependent protein kinases-I and -IV in long-term potentiation

Masaaki Tokuda, Bushra Y. Ahmed, Yun Fei Lu, Hideki Matsui, Osamu Miyamoto, Fuminori Yamaguchi, Ryoji Konishi, Osamu Hatase

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Abstract

Multifunctional Ca2+/calmodulin-dependent protein kinases (CaMKs) are thought to be involved in the induction of long-term potentiation (LTP). In the present study, LTP was induced by theta burst stimulation in the Schaffer collateral area of the stratum radiatum in the hippocampal CA1 region of the rat hippocampus. LTP-induced and control hippocampal slices were studied by Western blot and immunohistochemical analyses using CaMK-I, -II and -IV antibodies. Increased amounts of all three CaMKs were found in LTP-induced hippocampal slices as indicated by Western blot as well as by the density of their immunoreactivity. Our data clearly shows that not only CaMK-II but also CaMK-I and -IV contribute to synaptic plasticity formed in LTP.

Original languageEnglish
Pages (from-to)162-166
Number of pages5
JournalBrain Research
Volume755
Issue number1
DOIs
Publication statusPublished - Apr 25 1997

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Keywords

  • Ca/calmodulin-dependent protein kinase
  • hippocampus
  • immunohistochemistry
  • long-term potentiation
  • Western blot

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Tokuda, M., Ahmed, B. Y., Lu, Y. F., Matsui, H., Miyamoto, O., Yamaguchi, F., Konishi, R., & Hatase, O. (1997). Involvement of calmodulin-dependent protein kinases-I and -IV in long-term potentiation. Brain Research, 755(1), 162-166. https://doi.org/10.1016/S0006-8993(97)00189-3