Abstract
Alterations in the morphology and movement of mitochondria influence neuronal viability. However, the precise mechanisms of such alterations are unclear. In this study, we showed calcineurin was involved in the regulation of mitochondrial dynamics. Glutamate stimulation inhibited mitochondrial movement and decreased mitochondrial length in neurons. FK506 and cyclosporine A, calcineurin inhibitors, attenuated the effects of glutamate on mitochondrial dynamics. It was also found that glutamate treatment dephosphorylated, a proapoptotic protein, Bad and promoted its translocation to mitochondria in neurons via calcineurin. These results provide important new insights into intracellular signaling pathways that regulate mitochondrial dynamics and neuronal cell death.
| Original language | English |
|---|---|
| Pages (from-to) | 114-119 |
| Number of pages | 6 |
| Journal | Neuroscience Research |
| Volume | 60 |
| Issue number | 1 |
| DOIs | |
| Publication status | Published - Jan 2008 |
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Keywords
- Bad
- Calcineurin
- Calcium
- Mitochondria
- Neural excitation
- Neuronal cell death
- NMDA
ASJC Scopus subject areas
- Neuroscience(all)
Cite this
Involvement of calcineurin in glutamate-induced mitochondrial dynamics in neurons. / Han, Xiao Jian; Lu, Yun Fei; Li, Shun Ai; Tomizawa, Kazuhito; Takei, Kohji; Matsushita, Masayuki; Matsui, Hideki.
In: Neuroscience Research, Vol. 60, No. 1, 01.2008, p. 114-119.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Involvement of calcineurin in glutamate-induced mitochondrial dynamics in neurons
AU - Han, Xiao Jian
AU - Lu, Yun Fei
AU - Li, Shun Ai
AU - Tomizawa, Kazuhito
AU - Takei, Kohji
AU - Matsushita, Masayuki
AU - Matsui, Hideki
PY - 2008/1
Y1 - 2008/1
N2 - Alterations in the morphology and movement of mitochondria influence neuronal viability. However, the precise mechanisms of such alterations are unclear. In this study, we showed calcineurin was involved in the regulation of mitochondrial dynamics. Glutamate stimulation inhibited mitochondrial movement and decreased mitochondrial length in neurons. FK506 and cyclosporine A, calcineurin inhibitors, attenuated the effects of glutamate on mitochondrial dynamics. It was also found that glutamate treatment dephosphorylated, a proapoptotic protein, Bad and promoted its translocation to mitochondria in neurons via calcineurin. These results provide important new insights into intracellular signaling pathways that regulate mitochondrial dynamics and neuronal cell death.
AB - Alterations in the morphology and movement of mitochondria influence neuronal viability. However, the precise mechanisms of such alterations are unclear. In this study, we showed calcineurin was involved in the regulation of mitochondrial dynamics. Glutamate stimulation inhibited mitochondrial movement and decreased mitochondrial length in neurons. FK506 and cyclosporine A, calcineurin inhibitors, attenuated the effects of glutamate on mitochondrial dynamics. It was also found that glutamate treatment dephosphorylated, a proapoptotic protein, Bad and promoted its translocation to mitochondria in neurons via calcineurin. These results provide important new insights into intracellular signaling pathways that regulate mitochondrial dynamics and neuronal cell death.
KW - Bad
KW - Calcineurin
KW - Calcium
KW - Mitochondria
KW - Neural excitation
KW - Neuronal cell death
KW - NMDA
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UR - http://www.scopus.com/inward/citedby.url?scp=37549011358&partnerID=8YFLogxK
U2 - 10.1016/j.neures.2007.09.012
DO - 10.1016/j.neures.2007.09.012
M3 - Article
VL - 60
SP - 114
EP - 119
JO - Neuroscience Research
JF - Neuroscience Research
SN - 0168-0102
IS - 1
ER -