Abstract
Annexin (AX) is the name of a new family of Ca2+-dependent membrane binding proteins of which 13 members have been reported to date. Among these, AXI and AXII have been reported to possess many biological functions in vitro. Their actual roles in vivo, however, are as yet unknown. There have been no reports previously demonstrating the direct involvement of AXI and AXII in chronic hepatitis (CH), liver cirrhosis (LC) or hepatocellular carcinoma (HCC). The involvement of AXI and AXII in the etiological processes of CH, LC and HCC was investigated by Western blot and/or immunohistochemistry using anti-AXI and AXII antibodies. AXI and AXII were rarely detected in CH liver tissues, while they were found to be expressed at high levels in LC and HCC. AXI and AXII were present in the hepatocytes of LC and HCC and their subcellular localization was mainly cytoplasmic. These results indicate that AXI and AXII may act together in the occurrence and development of LC and HCC.
| Original language | English |
|---|---|
| Pages (from-to) | 113-119 |
| Number of pages | 7 |
| Journal | International Hepatology Communications |
| Volume | 4 |
| Issue number | 2 |
| DOIs | |
| Publication status | Published - 1995 |
| Externally published | Yes |
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Keywords
- Annexin
- Hepatocellular carcinoma
- Liver cirrhosis
ASJC Scopus subject areas
- Hepatology
Cite this
Involvement of Annexins I an II in human liver cirrhosis and hepatocellular carcinoma. / Masaki, Tsutomu; Tokuda, Masaaki; Ohnishi, Makoto; Tai, Yuji; Itano, Toshifumi; Matsui, Hideki; Watanabe, Seishiro; Arima, Keiji; Kohno, Kazumi; Maeba, Takashi; Ikeda, Yosikazu; Hatase, Osamu; Nishioka, Mikio.
In: International Hepatology Communications, Vol. 4, No. 2, 1995, p. 113-119.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Involvement of Annexins I an II in human liver cirrhosis and hepatocellular carcinoma
AU - Masaki, Tsutomu
AU - Tokuda, Masaaki
AU - Ohnishi, Makoto
AU - Tai, Yuji
AU - Itano, Toshifumi
AU - Matsui, Hideki
AU - Watanabe, Seishiro
AU - Arima, Keiji
AU - Kohno, Kazumi
AU - Maeba, Takashi
AU - Ikeda, Yosikazu
AU - Hatase, Osamu
AU - Nishioka, Mikio
PY - 1995
Y1 - 1995
N2 - Annexin (AX) is the name of a new family of Ca2+-dependent membrane binding proteins of which 13 members have been reported to date. Among these, AXI and AXII have been reported to possess many biological functions in vitro. Their actual roles in vivo, however, are as yet unknown. There have been no reports previously demonstrating the direct involvement of AXI and AXII in chronic hepatitis (CH), liver cirrhosis (LC) or hepatocellular carcinoma (HCC). The involvement of AXI and AXII in the etiological processes of CH, LC and HCC was investigated by Western blot and/or immunohistochemistry using anti-AXI and AXII antibodies. AXI and AXII were rarely detected in CH liver tissues, while they were found to be expressed at high levels in LC and HCC. AXI and AXII were present in the hepatocytes of LC and HCC and their subcellular localization was mainly cytoplasmic. These results indicate that AXI and AXII may act together in the occurrence and development of LC and HCC.
AB - Annexin (AX) is the name of a new family of Ca2+-dependent membrane binding proteins of which 13 members have been reported to date. Among these, AXI and AXII have been reported to possess many biological functions in vitro. Their actual roles in vivo, however, are as yet unknown. There have been no reports previously demonstrating the direct involvement of AXI and AXII in chronic hepatitis (CH), liver cirrhosis (LC) or hepatocellular carcinoma (HCC). The involvement of AXI and AXII in the etiological processes of CH, LC and HCC was investigated by Western blot and/or immunohistochemistry using anti-AXI and AXII antibodies. AXI and AXII were rarely detected in CH liver tissues, while they were found to be expressed at high levels in LC and HCC. AXI and AXII were present in the hepatocytes of LC and HCC and their subcellular localization was mainly cytoplasmic. These results indicate that AXI and AXII may act together in the occurrence and development of LC and HCC.
KW - Annexin
KW - Hepatocellular carcinoma
KW - Liver cirrhosis
UR - http://www.scopus.com/inward/record.url?scp=0029111480&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0029111480&partnerID=8YFLogxK
U2 - 10.1016/0928-4346(95)00213-3
DO - 10.1016/0928-4346(95)00213-3
M3 - Article
AN - SCOPUS:0029111480
VL - 4
SP - 113
EP - 119
JO - Hepatology Research
JF - Hepatology Research
SN - 1386-6346
IS - 2
ER -