Involvement of Annexins I an II in human liver cirrhosis and hepatocellular carcinoma

Tsutomu Masaki; Masaaki Tokuda; Makoto Ohnishi; Yuji Tai; Toshifumi Itano; Hideki Matsui; Seishiro Watanabe; Keiji Arima; Kazumi Kohno; Takashi Maeba; Yosikazu Ikeda; Osamu Hatase; Mikio Nishioka

doi:10.1016/0928-4346(95)00213-3

Involvement of Annexins I an II in human liver cirrhosis and hepatocellular carcinoma

Tsutomu Masaki, Masaaki Tokuda, Makoto Ohnishi, Yuji Tai, Toshifumi Itano, Hideki Matsui, Seishiro Watanabe, Keiji Arima, Kazumi Kohno, Takashi Maeba, Yosikazu Ikeda, Osamu Hatase, Mikio Nishioka

Research output: Contribution to journal › Article › peer-review

3 Citations (Scopus)

Abstract

Annexin (AX) is the name of a new family of Ca²⁺-dependent membrane binding proteins of which 13 members have been reported to date. Among these, AXI and AXII have been reported to possess many biological functions in vitro. Their actual roles in vivo, however, are as yet unknown. There have been no reports previously demonstrating the direct involvement of AXI and AXII in chronic hepatitis (CH), liver cirrhosis (LC) or hepatocellular carcinoma (HCC). The involvement of AXI and AXII in the etiological processes of CH, LC and HCC was investigated by Western blot and/or immunohistochemistry using anti-AXI and AXII antibodies. AXI and AXII were rarely detected in CH liver tissues, while they were found to be expressed at high levels in LC and HCC. AXI and AXII were present in the hepatocytes of LC and HCC and their subcellular localization was mainly cytoplasmic. These results indicate that AXI and AXII may act together in the occurrence and development of LC and HCC.

Original language	English
Pages (from-to)	113-119
Number of pages	7
Journal	International Hepatology Communications
Volume	4
Issue number	2
DOIs	https://doi.org/10.1016/0928-4346(95)00213-3
Publication status	Published - Aug 1995
Externally published	Yes

Keywords

Annexin
Hepatocellular carcinoma
Liver cirrhosis

ASJC Scopus subject areas

Hepatology

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/0928-4346(95)00213-3

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title = "Involvement of Annexins I an II in human liver cirrhosis and hepatocellular carcinoma",

abstract = "Annexin (AX) is the name of a new family of Ca2+-dependent membrane binding proteins of which 13 members have been reported to date. Among these, AXI and AXII have been reported to possess many biological functions in vitro. Their actual roles in vivo, however, are as yet unknown. There have been no reports previously demonstrating the direct involvement of AXI and AXII in chronic hepatitis (CH), liver cirrhosis (LC) or hepatocellular carcinoma (HCC). The involvement of AXI and AXII in the etiological processes of CH, LC and HCC was investigated by Western blot and/or immunohistochemistry using anti-AXI and AXII antibodies. AXI and AXII were rarely detected in CH liver tissues, while they were found to be expressed at high levels in LC and HCC. AXI and AXII were present in the hepatocytes of LC and HCC and their subcellular localization was mainly cytoplasmic. These results indicate that AXI and AXII may act together in the occurrence and development of LC and HCC.",

keywords = "Annexin, Hepatocellular carcinoma, Liver cirrhosis",

author = "Tsutomu Masaki and Masaaki Tokuda and Makoto Ohnishi and Yuji Tai and Toshifumi Itano and Hideki Matsui and Seishiro Watanabe and Keiji Arima and Kazumi Kohno and Takashi Maeba and Yosikazu Ikeda and Osamu Hatase and Mikio Nishioka",

note = "Funding Information: We thank the staff of the Common Equipment Research Center of the Kagawa Medical School for their technical assistance. This work was supported by a Grant-in-Aid for Scientific Research from the Ministry of Education, Science and Culture of Japan.",

year = "1995",

month = aug,

doi = "10.1016/0928-4346(95)00213-3",

language = "English",

volume = "4",

pages = "113--119",

journal = "Hepatology Research",

issn = "1386-6346",

publisher = "Wiley-Blackwell",

number = "2",

}

TY - JOUR

T1 - Involvement of Annexins I an II in human liver cirrhosis and hepatocellular carcinoma

AU - Masaki, Tsutomu

AU - Tokuda, Masaaki

AU - Ohnishi, Makoto

AU - Tai, Yuji

AU - Itano, Toshifumi

AU - Matsui, Hideki

AU - Watanabe, Seishiro

AU - Arima, Keiji

AU - Kohno, Kazumi

AU - Maeba, Takashi

AU - Ikeda, Yosikazu

AU - Hatase, Osamu

AU - Nishioka, Mikio

N1 - Funding Information: We thank the staff of the Common Equipment Research Center of the Kagawa Medical School for their technical assistance. This work was supported by a Grant-in-Aid for Scientific Research from the Ministry of Education, Science and Culture of Japan.

PY - 1995/8

Y1 - 1995/8

N2 - Annexin (AX) is the name of a new family of Ca2+-dependent membrane binding proteins of which 13 members have been reported to date. Among these, AXI and AXII have been reported to possess many biological functions in vitro. Their actual roles in vivo, however, are as yet unknown. There have been no reports previously demonstrating the direct involvement of AXI and AXII in chronic hepatitis (CH), liver cirrhosis (LC) or hepatocellular carcinoma (HCC). The involvement of AXI and AXII in the etiological processes of CH, LC and HCC was investigated by Western blot and/or immunohistochemistry using anti-AXI and AXII antibodies. AXI and AXII were rarely detected in CH liver tissues, while they were found to be expressed at high levels in LC and HCC. AXI and AXII were present in the hepatocytes of LC and HCC and their subcellular localization was mainly cytoplasmic. These results indicate that AXI and AXII may act together in the occurrence and development of LC and HCC.

AB - Annexin (AX) is the name of a new family of Ca2+-dependent membrane binding proteins of which 13 members have been reported to date. Among these, AXI and AXII have been reported to possess many biological functions in vitro. Their actual roles in vivo, however, are as yet unknown. There have been no reports previously demonstrating the direct involvement of AXI and AXII in chronic hepatitis (CH), liver cirrhosis (LC) or hepatocellular carcinoma (HCC). The involvement of AXI and AXII in the etiological processes of CH, LC and HCC was investigated by Western blot and/or immunohistochemistry using anti-AXI and AXII antibodies. AXI and AXII were rarely detected in CH liver tissues, while they were found to be expressed at high levels in LC and HCC. AXI and AXII were present in the hepatocytes of LC and HCC and their subcellular localization was mainly cytoplasmic. These results indicate that AXI and AXII may act together in the occurrence and development of LC and HCC.

KW - Annexin

KW - Hepatocellular carcinoma

KW - Liver cirrhosis

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U2 - 10.1016/0928-4346(95)00213-3

DO - 10.1016/0928-4346(95)00213-3

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AN - SCOPUS:0029111480

VL - 4

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EP - 119

JO - Hepatology Research

JF - Hepatology Research

SN - 1386-6346

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ER -

Involvement of Annexins I an II in human liver cirrhosis and hepatocellular carcinoma

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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