Involvement of annexin I and annexin II in hepatocyte proliferation: Can annexins I and II be markers for proliferative hepatocytes?

Tsutomu Masaki, Masaaki Tokuda, Takashi Fujimura, Makoto Ohnishi, Yuji Tai, Kazuhiro Miyamoto, Toshifumi Itano, Hideki Matsui, Seishiro Watanabe, Ken ichi Sogawa, Takahisa Yamada, Ryoji Konishi, Mikio Nishioka, Osamu Hatase

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Abstract

Annexin is the name of a new family of Ca2+-dependent membrane-binding proteins. Eleven types of its related proteins have been reported to date. Among those, annexin I and annexin II have been reported to possess many biological functions in vitro. Its actual role in vivo, however, is yet unknown. The involvement of annexin I and annexin II in the proliferation processes of hepatocytes was examined in the following aspects: (a) hepatocyte proliferation after carbon tetrachloride-induced liver damage, (b) hepatocyte regeneration after partial hepatectomy and (c) postnatal development of hepatocytes. These results showed collectively that annexin I and annexin II were increased in proliferative (or regenerative) hepatocytes, suggesting that both proteins play a certain role in the proliferation event. Furthermore, annexin I-and annexin II-positive hepatocytes always show a wider distribution than that of proliferating cell nuclear antigen or cytokeratin 7-positive hepatocytes, indicating that annexin I and annexin II may be useful markers for detecting not only actively proliferating hepatocytes but also hepatocytes in preproliferative and postproliferative stages.

Original languageEnglish
Pages (from-to)425-435
Number of pages11
JournalHepatology
Volume20
Issue number2
DOIs
Publication statusPublished - Aug 1994
Externally publishedYes

ASJC Scopus subject areas

  • Hepatology

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    Masaki, T., Tokuda, M., Fujimura, T., Ohnishi, M., Tai, Y., Miyamoto, K., Itano, T., Matsui, H., Watanabe, S., Sogawa, K. I., Yamada, T., Konishi, R., Nishioka, M., & Hatase, O. (1994). Involvement of annexin I and annexin II in hepatocyte proliferation: Can annexins I and II be markers for proliferative hepatocytes? Hepatology, 20(2), 425-435. https://doi.org/10.1002/hep.1840200224