TY - JOUR
T1 - Involvement of annexin I and annexin II in hepatocyte proliferation
T2 - Can annexins I and II be markers for proliferative hepatocytes?
AU - Masaki, Tsutomu
AU - Tokuda, Masaaki
AU - Fujimura, Takashi
AU - Ohnishi, Makoto
AU - Tai, Yuji
AU - Miyamoto, Kazuhiro
AU - Itano, Toshifumi
AU - Matsui, Hideki
AU - Watanabe, Seishiro
AU - Sogawa, Ken ichi
AU - Yamada, Takahisa
AU - Konishi, Ryoji
AU - Nishioka, Mikio
AU - Hatase, Osamu
PY - 1994/8
Y1 - 1994/8
N2 - Annexin is the name of a new family of Ca2+-dependent membrane-binding proteins. Eleven types of its related proteins have been reported to date. Among those, annexin I and annexin II have been reported to possess many biological functions in vitro. Its actual role in vivo, however, is yet unknown. The involvement of annexin I and annexin II in the proliferation processes of hepatocytes was examined in the following aspects: (a) hepatocyte proliferation after carbon tetrachloride-induced liver damage, (b) hepatocyte regeneration after partial hepatectomy and (c) postnatal development of hepatocytes. These results showed collectively that annexin I and annexin II were increased in proliferative (or regenerative) hepatocytes, suggesting that both proteins play a certain role in the proliferation event. Furthermore, annexin I-and annexin II-positive hepatocytes always show a wider distribution than that of proliferating cell nuclear antigen or cytokeratin 7-positive hepatocytes, indicating that annexin I and annexin II may be useful markers for detecting not only actively proliferating hepatocytes but also hepatocytes in preproliferative and postproliferative stages.
AB - Annexin is the name of a new family of Ca2+-dependent membrane-binding proteins. Eleven types of its related proteins have been reported to date. Among those, annexin I and annexin II have been reported to possess many biological functions in vitro. Its actual role in vivo, however, is yet unknown. The involvement of annexin I and annexin II in the proliferation processes of hepatocytes was examined in the following aspects: (a) hepatocyte proliferation after carbon tetrachloride-induced liver damage, (b) hepatocyte regeneration after partial hepatectomy and (c) postnatal development of hepatocytes. These results showed collectively that annexin I and annexin II were increased in proliferative (or regenerative) hepatocytes, suggesting that both proteins play a certain role in the proliferation event. Furthermore, annexin I-and annexin II-positive hepatocytes always show a wider distribution than that of proliferating cell nuclear antigen or cytokeratin 7-positive hepatocytes, indicating that annexin I and annexin II may be useful markers for detecting not only actively proliferating hepatocytes but also hepatocytes in preproliferative and postproliferative stages.
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U2 - 10.1002/hep.1840200224
DO - 10.1002/hep.1840200224
M3 - Article
C2 - 7519163
AN - SCOPUS:0028070429
VL - 20
SP - 425
EP - 435
JO - Hepatology
JF - Hepatology
SN - 0270-9139
IS - 2
ER -