Abstract
Annexin is the name of a new family of Ca2+-dependent membrane-binding proteins. Eleven types of its related proteins have been reported to date. Among those, annexin I and annexin II have been reported to possess many biological functions in vitro. Its actual role in vivo, however, is yet unknown. The involvement of annexin I and annexin II in the proliferation processes of hepatocytes was examined in the following aspects: (a) hepatocyte proliferation after carbon tetrachloride-induced liver damage, (b) hepatocyte regeneration after partial hepatectomy and (c) postnatal development of hepatocytes. These results showed collectively that annexin I and annexin II were increased in proliferative (or regenerative) hepatocytes, suggesting that both proteins play a certain role in the proliferation event. Furthermore, annexin I-and annexin II-positive hepatocytes always show a wider distribution than that of proliferating cell nuclear antigen or cytokeratin 7-positive hepatocytes, indicating that annexin I and annexin II may be useful markers for detecting not only actively proliferating hepatocytes but also hepatocytes in preproliferative and postproliferative stages.
| Original language | English |
|---|---|
| Pages (from-to) | 425-435 |
| Number of pages | 11 |
| Journal | Hepatology |
| Volume | 20 |
| Issue number | 2 |
| DOIs | |
| Publication status | Published - Aug 1994 |
| Externally published | Yes |
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ASJC Scopus subject areas
- Hepatology
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Involvement of annexin I and annexin II in hepatocyte proliferation : Can annexins I and II be markers for proliferative hepatocytes? / Masaki, Tsutomu; Tokuda, Masaaki; Fujimura, Takashi; Ohnishi, Makoto; Tai, Yuji; Miyamoto, Kazuhiro; Itano, Toshifumi; Matsui, Hideki; Watanabe, Seishiro; Sogawa, Ken ichi; Yamada, Takahisa; Konishi, Ryoji; Nishioka, Mikio; Hatase, Osamu.
In: Hepatology, Vol. 20, No. 2, 08.1994, p. 425-435.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Involvement of annexin I and annexin II in hepatocyte proliferation
T2 - Can annexins I and II be markers for proliferative hepatocytes?
AU - Masaki, Tsutomu
AU - Tokuda, Masaaki
AU - Fujimura, Takashi
AU - Ohnishi, Makoto
AU - Tai, Yuji
AU - Miyamoto, Kazuhiro
AU - Itano, Toshifumi
AU - Matsui, Hideki
AU - Watanabe, Seishiro
AU - Sogawa, Ken ichi
AU - Yamada, Takahisa
AU - Konishi, Ryoji
AU - Nishioka, Mikio
AU - Hatase, Osamu
PY - 1994/8
Y1 - 1994/8
N2 - Annexin is the name of a new family of Ca2+-dependent membrane-binding proteins. Eleven types of its related proteins have been reported to date. Among those, annexin I and annexin II have been reported to possess many biological functions in vitro. Its actual role in vivo, however, is yet unknown. The involvement of annexin I and annexin II in the proliferation processes of hepatocytes was examined in the following aspects: (a) hepatocyte proliferation after carbon tetrachloride-induced liver damage, (b) hepatocyte regeneration after partial hepatectomy and (c) postnatal development of hepatocytes. These results showed collectively that annexin I and annexin II were increased in proliferative (or regenerative) hepatocytes, suggesting that both proteins play a certain role in the proliferation event. Furthermore, annexin I-and annexin II-positive hepatocytes always show a wider distribution than that of proliferating cell nuclear antigen or cytokeratin 7-positive hepatocytes, indicating that annexin I and annexin II may be useful markers for detecting not only actively proliferating hepatocytes but also hepatocytes in preproliferative and postproliferative stages.
AB - Annexin is the name of a new family of Ca2+-dependent membrane-binding proteins. Eleven types of its related proteins have been reported to date. Among those, annexin I and annexin II have been reported to possess many biological functions in vitro. Its actual role in vivo, however, is yet unknown. The involvement of annexin I and annexin II in the proliferation processes of hepatocytes was examined in the following aspects: (a) hepatocyte proliferation after carbon tetrachloride-induced liver damage, (b) hepatocyte regeneration after partial hepatectomy and (c) postnatal development of hepatocytes. These results showed collectively that annexin I and annexin II were increased in proliferative (or regenerative) hepatocytes, suggesting that both proteins play a certain role in the proliferation event. Furthermore, annexin I-and annexin II-positive hepatocytes always show a wider distribution than that of proliferating cell nuclear antigen or cytokeratin 7-positive hepatocytes, indicating that annexin I and annexin II may be useful markers for detecting not only actively proliferating hepatocytes but also hepatocytes in preproliferative and postproliferative stages.
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UR - http://www.scopus.com/inward/citedby.url?scp=0028070429&partnerID=8YFLogxK
U2 - 10.1002/hep.1840200224
DO - 10.1002/hep.1840200224
M3 - Article
VL - 20
SP - 425
EP - 435
JO - Hepatology
JF - Hepatology
SN - 0270-9139
IS - 2
ER -