Involvement of Androgen-Induced Growth Factor (FGF-8) Gene in Mouse Embryogenesis and Morphogenesis

Hideyo Ohuchi, H. Yoshioka, A. Tanaka, Y. Kawakami, T. Nohno, S. Noji

Research output: Contribution to journalArticle

153 Citations (Scopus)

Abstract

Androgen-induced growth factor (AIGF/FGF-8) has purified from a mouse mammary carcinoma cell line and its cDNA cloning revealed that AIGF is the eighth member of the fibroblast growth factor family. To clarify a biological role of FGF-8, Northern blot analysis of various adult tissues was carried out, but no expression was found. However, whole mount in situ hybridization of 7.5- to 14.5-day gestation (E7.5-14.5) embryos revealed six predominant expression domains: [1]primitive streak region (E7.5-9.75); [2]midbrain-hindbrain border (E8.0-10.5); [3]rostral forebrain (E8.0-10.5); [4]limb ectoderm and apical ectodermal ridge (E9.25-13.5); [5]nasal placode and epithelium (E9.5-12.5); and [6]branchial arch ectoderm (E8.5-11.5). The embryonic expression pattern suggests a unique role of FGF-8 in mouse development, especially in gastrulation, brain development, and limb and facial morphogenesis.

Original languageEnglish
Pages (from-to)882-888
Number of pages7
JournalBiochemical and Biophysical Research Communications
Volume204
Issue number2
DOIs
Publication statusPublished - Oct 31 1994
Externally publishedYes

Fingerprint

Fibroblast Growth Factor 8
Ectoderm
Fibroblast Growth Factors
Cloning
Arches
Morphogenesis
Embryonic Development
Brain
Extremities
Complementary DNA
Genes
Cells
Primitive Streak
Tissue
Branchial Region
Gastrulation
Rhombencephalon
Nasal Mucosa
Prosencephalon
Mesencephalon

ASJC Scopus subject areas

  • Molecular Biology
  • Biophysics
  • Biochemistry

Cite this

Involvement of Androgen-Induced Growth Factor (FGF-8) Gene in Mouse Embryogenesis and Morphogenesis. / Ohuchi, Hideyo; Yoshioka, H.; Tanaka, A.; Kawakami, Y.; Nohno, T.; Noji, S.

In: Biochemical and Biophysical Research Communications, Vol. 204, No. 2, 31.10.1994, p. 882-888.

Research output: Contribution to journalArticle

Ohuchi, Hideyo ; Yoshioka, H. ; Tanaka, A. ; Kawakami, Y. ; Nohno, T. ; Noji, S. / Involvement of Androgen-Induced Growth Factor (FGF-8) Gene in Mouse Embryogenesis and Morphogenesis. In: Biochemical and Biophysical Research Communications. 1994 ; Vol. 204, No. 2. pp. 882-888.
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