Investigation of serum Cu, Zn-SOD concentration by ELISA and histological localization in hepatocellular carcinoma (HCC) using anti-human Cu, Zn-SOD monoclonal antibody

Isao Sakaida, Keiki Ogino, Shinji Oka, Shinjiro Matsuura, Shunji Yoshimura, Kazuya Matsuda, Toshiyuki Sasaki, Kasunari Yamamoto, Keiiiro Ando, Yohei Fukumoto, Kiwamu Okita, Yukinori Okazaki, Tadayoshi Takemoto, Taizo Uda

Research output: Contribution to journalArticle

Abstract

Serum Cu, Zn-SOD concentration and histological localization of patients with HCC were examined using anti-human Cu, Zn-SOD monoclonal antibody. The serum Cu, Zn-SOD concentration of patients with HCC was significantly elevated compared with healthy adults and also patients with liver cirrhosis but there was no correlation between serum Cu, Zn-SOD and serum GPT, GOT, AFP values. There are many reports that diminishing amounts of Cu, Zn-SOD activity were found in tumors, but our histological results show that in about 20% of our specimens Cu, Zn-SOD was strongly stained in tumors. This may indicae that amounts of Cu, Zn-SOD were quantitatively increased in tumors. These results suggest that it is possible for Cu, Zn-SOD to be a new marker for HCC and a possible reason for the existence of anti-cancer drug resistant HCC, for example such as adriamycin which kills the tumor cells mainly with active oxygen.

Original languageEnglish
Pages (from-to)1211-1218
Number of pages8
JournalKanzo
Volume28
Issue number9
DOIs
Publication statusPublished - Jan 1 1987

ASJC Scopus subject areas

  • Hepatology

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