Investigation of multilayered protein adsorption on carbonate apatite with a QCM technique

Tomohiko Yoshioka, Hiroshi Yonekura, Toshiyuki Ikoma, Motohiro Tagaya, Junzo Tanaka

Research output: Chapter in Book/Report/Conference proceedingConference contribution

2 Citations (Scopus)

Abstract

This study is concerned with multilayered protein adsorption on carbonate apatite (CAp) that is measured with a quartz crystal microbalance (QCM) technique. A carbonate apatite-deposited QCM sensor was prepared by electrophoretic deposition (EPD). On the CAp-deposited QCM sensor, fibrinogen adsorption followed by thrombin adsorption was investigated. The adsorption of fibrinogen on CAp led to a clear decrease in the resonance frequency of the sensor, which means that fibrinogen adsorbed on the CAp-deposited QCM sensor. The adsorbed amount of fibrinogen was larger on CAp than on a pristine sensor (Au). Although successive thrombin adsorption occurred on fibrinogen adlayers on both CAp and Au, the adsorbed amount and its conformation were different depending on the surface.

Original languageEnglish
Title of host publicationBioceramics 24
PublisherTrans Tech Publications Ltd
Pages74-77
Number of pages4
Edition1
ISBN (Print)9783037855171
DOIs
Publication statusPublished - Jan 1 2013
Externally publishedYes
Event24th Symposium and Annual Meeting of International Society for Ceramics in Medicine, ISCM 2012 - Fukuoka, Japan
Duration: Oct 21 2012Oct 24 2012

Publication series

NameKey Engineering Materials
Number1
Volume529-530
ISSN (Print)1013-9826
ISSN (Electronic)1662-9795

Other

Other24th Symposium and Annual Meeting of International Society for Ceramics in Medicine, ISCM 2012
CountryJapan
CityFukuoka
Period10/21/1210/24/12

Keywords

  • Carbonate apatite
  • Protein adsorption
  • Quartz crystal microbalance (QCM)

ASJC Scopus subject areas

  • Materials Science(all)
  • Mechanics of Materials
  • Mechanical Engineering

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  • Cite this

    Yoshioka, T., Yonekura, H., Ikoma, T., Tagaya, M., & Tanaka, J. (2013). Investigation of multilayered protein adsorption on carbonate apatite with a QCM technique. In Bioceramics 24 (1 ed., pp. 74-77). (Key Engineering Materials; Vol. 529-530, No. 1). Trans Tech Publications Ltd. https://doi.org/10.4028/www.scientific.net/KEM.529-530.74