Investigation of CXCR4 in squamous cell carcinoma of the tongue

Cagri B. Delilbasi, Masaya Okura, Seiji Iida, Mikihiko Kogo

Research output: Contribution to journalArticle

44 Citations (Scopus)

Abstract

Cancer metastasis is not a random process and different cancer types have favorite metastatic sites. Recent studies on metastasis have focused on chemoattraction, particularly on the role of chemokines. Therefore, in this study we investigated whether CXCR4 (receptor for stromal cell-derived factor-1) is expressed in squamous cell carcinoma of the tongue. For this purpose, immunohistochemical staining was performed on 26 sections obtained from 23 patients (15 patients having tongue tumor without lymph node metastasis and eight patients having lymph node metastasis). All tumor cells expressed CXCR4, whereas normal mucosa of the tongue had no or faint expression CXCR4. Metastatic tumor cells in lymph nodes had stronger expression than primary tongue tumor cells. Our data raises the possibility that CXCR4 could be involved in lymph node metastasis of oral squamous cell carcinoma.

Original languageEnglish
Pages (from-to)154-157
Number of pages4
JournalOral Oncology
Volume40
Issue number2
DOIs
Publication statusPublished - Feb 2004
Externally publishedYes

Fingerprint

Tongue
Squamous Cell Carcinoma
Neoplasm Metastasis
Lymph Nodes
Neoplasms
CXCR4 Receptors
Chemokine CXCL12
Chemokines
Mucous Membrane
Staining and Labeling

Keywords

  • Chemokine
  • CXCR4
  • Lymph node
  • Metastasis
  • Squamous cell carcinoma
  • Tongue

ASJC Scopus subject areas

  • Oncology

Cite this

Investigation of CXCR4 in squamous cell carcinoma of the tongue. / Delilbasi, Cagri B.; Okura, Masaya; Iida, Seiji; Kogo, Mikihiko.

In: Oral Oncology, Vol. 40, No. 2, 02.2004, p. 154-157.

Research output: Contribution to journalArticle

Delilbasi, Cagri B. ; Okura, Masaya ; Iida, Seiji ; Kogo, Mikihiko. / Investigation of CXCR4 in squamous cell carcinoma of the tongue. In: Oral Oncology. 2004 ; Vol. 40, No. 2. pp. 154-157.
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