Abstract
In summary, a change in the configuration of a single amino acid in a β3-heptapeptide can lead to remarkable changes in the physicochemical properties of the peptide with respect to the interaction with a (protein-free) biomimetic environment. Thus, the presence of an unnatural amino acid configuration in a peptide can have consequences not only with respect to specific interactions with proteins, but also, indirectly, with respect to the interaction with membrane lipids.
| Original language | English |
|---|---|
| Pages (from-to) | 1978-1981 |
| Number of pages | 4 |
| Journal | ChemBioChem |
| Volume | 10 |
| Issue number | 12 |
| DOIs | |
| Publication status | Published - Aug 17 2009 |
| Externally published | Yes |
Fingerprint
Keywords
- Liposomes
- Peptides
- Phospholipids
- Structure-property relationships
- Vesicles
ASJC Scopus subject areas
- Biochemistry
- Organic Chemistry
- Molecular Medicine
- Molecular Biology
Cite this
Inversion of the configuration of a single stereocenter in a β-heptapeptide leads to drastic changes in its interaction with phospholipid bilayers. / Shimanouchi, Toshinori; Walde, Peter; Gardiner, James; Capone, Stefania; Seebach, Dieter; Kuboi, Ryochi.
In: ChemBioChem, Vol. 10, No. 12, 17.08.2009, p. 1978-1981.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Inversion of the configuration of a single stereocenter in a β-heptapeptide leads to drastic changes in its interaction with phospholipid bilayers
AU - Shimanouchi, Toshinori
AU - Walde, Peter
AU - Gardiner, James
AU - Capone, Stefania
AU - Seebach, Dieter
AU - Kuboi, Ryochi
PY - 2009/8/17
Y1 - 2009/8/17
N2 - In summary, a change in the configuration of a single amino acid in a β3-heptapeptide can lead to remarkable changes in the physicochemical properties of the peptide with respect to the interaction with a (protein-free) biomimetic environment. Thus, the presence of an unnatural amino acid configuration in a peptide can have consequences not only with respect to specific interactions with proteins, but also, indirectly, with respect to the interaction with membrane lipids.
AB - In summary, a change in the configuration of a single amino acid in a β3-heptapeptide can lead to remarkable changes in the physicochemical properties of the peptide with respect to the interaction with a (protein-free) biomimetic environment. Thus, the presence of an unnatural amino acid configuration in a peptide can have consequences not only with respect to specific interactions with proteins, but also, indirectly, with respect to the interaction with membrane lipids.
KW - Liposomes
KW - Peptides
KW - Phospholipids
KW - Structure-property relationships
KW - Vesicles
UR - http://www.scopus.com/inward/record.url?scp=70349546317&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=70349546317&partnerID=8YFLogxK
U2 - 10.1002/cbic.200900175
DO - 10.1002/cbic.200900175
M3 - Article
C2 - 19575370
AN - SCOPUS:70349546317
VL - 10
SP - 1978
EP - 1981
JO - ChemBioChem
JF - ChemBioChem
SN - 1439-4227
IS - 12
ER -