Inversion of the configuration of a single stereocenter in a β-heptapeptide leads to drastic changes in its interaction with phospholipid bilayers

Toshinori Shimanouchi, Peter Walde, James Gardiner, Stefania Capone, Dieter Seebach, Ryochi Kuboi

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

In summary, a change in the configuration of a single amino acid in a β3-heptapeptide can lead to remarkable changes in the physicochemical properties of the peptide with respect to the interaction with a (protein-free) biomimetic environment. Thus, the presence of an unnatural amino acid configuration in a peptide can have consequences not only with respect to specific interactions with proteins, but also, indirectly, with respect to the interaction with membrane lipids.

Original languageEnglish
Pages (from-to)1978-1981
Number of pages4
JournalChemBioChem
Volume10
Issue number12
DOIs
Publication statusPublished - Aug 17 2009
Externally publishedYes

Keywords

  • Liposomes
  • Peptides
  • Phospholipids
  • Structure-property relationships
  • Vesicles

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Medicine
  • Molecular Biology
  • Organic Chemistry

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