TY - JOUR
T1 - Inversion of the configuration of a single stereocenter in a β-heptapeptide leads to drastic changes in its interaction with phospholipid bilayers
AU - Shimanouchi, Toshinori
AU - Walde, Peter
AU - Gardiner, James
AU - Capone, Stefania
AU - Seebach, Dieter
AU - Kuboi, Ryochi
PY - 2009/8/17
Y1 - 2009/8/17
N2 - In summary, a change in the configuration of a single amino acid in a β3-heptapeptide can lead to remarkable changes in the physicochemical properties of the peptide with respect to the interaction with a (protein-free) biomimetic environment. Thus, the presence of an unnatural amino acid configuration in a peptide can have consequences not only with respect to specific interactions with proteins, but also, indirectly, with respect to the interaction with membrane lipids.
AB - In summary, a change in the configuration of a single amino acid in a β3-heptapeptide can lead to remarkable changes in the physicochemical properties of the peptide with respect to the interaction with a (protein-free) biomimetic environment. Thus, the presence of an unnatural amino acid configuration in a peptide can have consequences not only with respect to specific interactions with proteins, but also, indirectly, with respect to the interaction with membrane lipids.
KW - Liposomes
KW - Peptides
KW - Phospholipids
KW - Structure-property relationships
KW - Vesicles
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U2 - 10.1002/cbic.200900175
DO - 10.1002/cbic.200900175
M3 - Article
C2 - 19575370
AN - SCOPUS:70349546317
VL - 10
SP - 1978
EP - 1981
JO - ChemBioChem
JF - ChemBioChem
SN - 1439-4227
IS - 12
ER -