Intravesical capsaicin in neurologic impaired patients with detrusor hyperreflexia

Akhil Das, Michael B. Chancellor, Toyohiko Watanabe, John Sedor, David A. Rivas

Research output: Contribution to journalArticlepeer-review

36 Citations (Scopus)

Abstract

Capsaicin is known to be neurotoxic for C-fiber afferents. We investigated the intravesical application of capsaicin in the treatment of detrusor hyperreflexia (DH) in seven patients (ages 23-52) with neurologic impairment. The patients were evaluated with both ice-water cystometry and formal video-urodynamic studies. Four biweekly courses of intravesical capsaicin treatment were administered using increasing concentrations (100 μM, 500 μM, 1 mM and 2 mM). Treatment effect was monitored using a bladder diary and urodynamic evaluation one month after capsaicin treatment. Prior to treatment, six of the seven patients demonstrated a positive ice-water test and DH. Two patients were not able to complete the study due to discomfort attributed to capsaicin. Five of the seven patients completed the four courses of increasingly concentrated capsaicin. Three patients noted symptomatic improvement while two did not. The mean urodynamic bladder capacity significantly increased from 124±39 ml pre-capsaicin to 231±62 ml one month post-capsaicin in the three patients with symptomatic improvement (p<0.05). Urodynamic testing revealed that one of the six patients with a positive ice-water test lost that response after intravesical capsaicin. Intravesical capsaicin is a novel and promising treatment for detrusor hyperreflexia in neurologically impaired patients.

Original languageEnglish
Pages (from-to)190-193
Number of pages4
JournalJournal of Spinal Cord Medicine
Volume19
Issue number3
DOIs
Publication statusPublished - Jul 1996
Externally publishedYes

Keywords

  • Capsaicin
  • Incontinence
  • Neurogenic bladder
  • Spinal cord injury
  • Urodynamics

ASJC Scopus subject areas

  • Clinical Neurology

Fingerprint Dive into the research topics of 'Intravesical capsaicin in neurologic impaired patients with detrusor hyperreflexia'. Together they form a unique fingerprint.

Cite this