Abstract
Several inflammatory and immunological factors have been established as important contributors to atherogenesis. Among these, oxidized low-density lipoprotein (oxLDL) play a central role in the initiation and progression of atherosclerotic lesions. In atherosclerotic lesions, oxLDL was also found to co-localize with β2-glycoprotein I (β2-GPI). Immunoglobulin (Ig)G autoantibodies against β2-GPI complexed with oxLDL are pro-atherogenic because they increase uptake of the complexes by macrophages. In contrast, IgM natural anti-oxLDL antibodies derived from atherosclerosis-prone apolipoprotein E (ApoE) deficient mice reduced incidence of atherosclerosis. Such anti-oxLDL antibodies have been found in humans, and the accumulating evidences seem to support the idea that anti-oxLDL antibodies have a protective role for atherogenesis. Intravenous immunoglobulins (IVIgs) contain natural anti-oxLDL antibodies and infusion of IVIg into ApoE-deficient mice has been reported to decrease atheerosclerosis. The anti-atherogenic property of IVIg may be derived from non-antigen-specific antibody binding to FCγ receptors, which blocks foam cell formation of macrophages. Several other possible mechanisms are also discussed.
| Original language | English |
|---|---|
| Pages (from-to) | 311-320 |
| Number of pages | 10 |
| Journal | Clinical Reviews in Allergy and Immunology |
| Volume | 29 |
| Issue number | 3 |
| DOIs | |
| Publication status | Published - Dec 2005 |
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Keywords
- β-glycoprotein I (β-GPI)
- Anti-oxLDL antibody
- Atherosclerosis
- Intravenous immunoglobulin (IVIg)
- Oxidized low-density lipoprotien (oxLDL)
ASJC Scopus subject areas
- Immunology and Allergy
Cite this
Intravenous immunoglobulin and atherosclerosis. / Matsuura, Eiji; Kobayashi, Kazuko; Inoue, Katsumi; Shoenfeld, Yehuda.
In: Clinical Reviews in Allergy and Immunology, Vol. 29, No. 3, 12.2005, p. 311-320.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Intravenous immunoglobulin and atherosclerosis
AU - Matsuura, Eiji
AU - Kobayashi, Kazuko
AU - Inoue, Katsumi
AU - Shoenfeld, Yehuda
PY - 2005/12
Y1 - 2005/12
N2 - Several inflammatory and immunological factors have been established as important contributors to atherogenesis. Among these, oxidized low-density lipoprotein (oxLDL) play a central role in the initiation and progression of atherosclerotic lesions. In atherosclerotic lesions, oxLDL was also found to co-localize with β2-glycoprotein I (β2-GPI). Immunoglobulin (Ig)G autoantibodies against β2-GPI complexed with oxLDL are pro-atherogenic because they increase uptake of the complexes by macrophages. In contrast, IgM natural anti-oxLDL antibodies derived from atherosclerosis-prone apolipoprotein E (ApoE) deficient mice reduced incidence of atherosclerosis. Such anti-oxLDL antibodies have been found in humans, and the accumulating evidences seem to support the idea that anti-oxLDL antibodies have a protective role for atherogenesis. Intravenous immunoglobulins (IVIgs) contain natural anti-oxLDL antibodies and infusion of IVIg into ApoE-deficient mice has been reported to decrease atheerosclerosis. The anti-atherogenic property of IVIg may be derived from non-antigen-specific antibody binding to FCγ receptors, which blocks foam cell formation of macrophages. Several other possible mechanisms are also discussed.
AB - Several inflammatory and immunological factors have been established as important contributors to atherogenesis. Among these, oxidized low-density lipoprotein (oxLDL) play a central role in the initiation and progression of atherosclerotic lesions. In atherosclerotic lesions, oxLDL was also found to co-localize with β2-glycoprotein I (β2-GPI). Immunoglobulin (Ig)G autoantibodies against β2-GPI complexed with oxLDL are pro-atherogenic because they increase uptake of the complexes by macrophages. In contrast, IgM natural anti-oxLDL antibodies derived from atherosclerosis-prone apolipoprotein E (ApoE) deficient mice reduced incidence of atherosclerosis. Such anti-oxLDL antibodies have been found in humans, and the accumulating evidences seem to support the idea that anti-oxLDL antibodies have a protective role for atherogenesis. Intravenous immunoglobulins (IVIgs) contain natural anti-oxLDL antibodies and infusion of IVIg into ApoE-deficient mice has been reported to decrease atheerosclerosis. The anti-atherogenic property of IVIg may be derived from non-antigen-specific antibody binding to FCγ receptors, which blocks foam cell formation of macrophages. Several other possible mechanisms are also discussed.
KW - β-glycoprotein I (β-GPI)
KW - Anti-oxLDL antibody
KW - Atherosclerosis
KW - Intravenous immunoglobulin (IVIg)
KW - Oxidized low-density lipoprotien (oxLDL)
UR - http://www.scopus.com/inward/record.url?scp=29944438053&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=29944438053&partnerID=8YFLogxK
U2 - 10.1385/CRIAI:29:3:311
DO - 10.1385/CRIAI:29:3:311
M3 - Article
C2 - 16391407
AN - SCOPUS:29944438053
VL - 29
SP - 311
EP - 320
JO - Clinical Reviews in Allergy and Immunology
JF - Clinical Reviews in Allergy and Immunology
SN - 1080-0549
IS - 3
ER -