Intravenous dexmedetomidine for cesarean delivery and its concentration in colostrum

M. Yoshimura, T. Kunisawa, Manabu Suno, A. Sugawara, A. Kurosawa, R. Nakanishi, K. Aoki, T. Toriumi

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Background: Dexmedetomidine is a sedative agent with high α2-adrenoreceptor selectivity. We investigated intravenous Dexmedetomidine administration during scheduled cesarean delivery under neuraxial anesthesia; and concentration in the colostrum. Methods: Twenty-seven participants having elective cesarean delivery under combined spinal-epidural anesthesia were enrolled. After delivery and cord clamping, 6. μg/kg/h of intravenous dexmedetomidine was administered for 10. minutes, followed by a dose of 0.7. μg/kg/h until peritoneal closure. Sedation, vital signs and side effects were recorded. Blood and colostrum samples were collected from each participant at 6, 12, and 24. h after dexmedetomidine administration. Samples were analysed using liquid chromatography tandem-mass spectroscopy. Results: Colostrum samples were collected from 10 patients. The median [95% CI] plasma dexmedetomidine concentration was 333 [303-534] pg/ml at 0. h and 19.7 [13.5-25.8] pg/ml at 6. h. The colostrum concentration was 12.3 [8.1-20.1] pg/ml at 6. h. The dexmedetomidine completely disappeared from both within 24. h. The calculated milk-to-plasma ratio at 6. h was 0.76 [0.57-0.86]. The relative infant dose was 0.034% [0.020-0.062%]. At dexmedetomidine discontinuation, the Richmond Agitation-Sedation Scale score was -2 (range,-4 to -1). During surgery, no patients complained of nausea, peritoneal irritation or afterbirth pain. Conclusions: The dexmedetomidine milk-to-plasma ratio did not exceed 1 in any participant, and the relative infant dose was very low. Maternal sedation using dexmedetomidine is unlikely to be harmful for the infant.

Original languageEnglish
JournalInternational Journal of Obstetric Anesthesia
DOIs
Publication statusAccepted/In press - 2017

Fingerprint

Dexmedetomidine
Colostrum
Milk
Vital Signs
Epidural Anesthesia
Spinal Anesthesia
Hypnotics and Sedatives
Constriction
Liquid Chromatography
Intravenous Administration
Nausea
Mass Spectrometry
Anesthesia
Mothers
Pain

Keywords

  • Colostrum
  • Dexmedetomidine
  • Milk-to-plasma ratio
  • Relative infant dose

ASJC Scopus subject areas

  • Obstetrics and Gynaecology
  • Anesthesiology and Pain Medicine

Cite this

Intravenous dexmedetomidine for cesarean delivery and its concentration in colostrum. / Yoshimura, M.; Kunisawa, T.; Suno, Manabu; Sugawara, A.; Kurosawa, A.; Nakanishi, R.; Aoki, K.; Toriumi, T.

In: International Journal of Obstetric Anesthesia, 2017.

Research output: Contribution to journalArticle

Yoshimura, M. ; Kunisawa, T. ; Suno, Manabu ; Sugawara, A. ; Kurosawa, A. ; Nakanishi, R. ; Aoki, K. ; Toriumi, T. / Intravenous dexmedetomidine for cesarean delivery and its concentration in colostrum. In: International Journal of Obstetric Anesthesia. 2017.
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abstract = "Background: Dexmedetomidine is a sedative agent with high α2-adrenoreceptor selectivity. We investigated intravenous Dexmedetomidine administration during scheduled cesarean delivery under neuraxial anesthesia; and concentration in the colostrum. Methods: Twenty-seven participants having elective cesarean delivery under combined spinal-epidural anesthesia were enrolled. After delivery and cord clamping, 6. μg/kg/h of intravenous dexmedetomidine was administered for 10. minutes, followed by a dose of 0.7. μg/kg/h until peritoneal closure. Sedation, vital signs and side effects were recorded. Blood and colostrum samples were collected from each participant at 6, 12, and 24. h after dexmedetomidine administration. Samples were analysed using liquid chromatography tandem-mass spectroscopy. Results: Colostrum samples were collected from 10 patients. The median [95{\%} CI] plasma dexmedetomidine concentration was 333 [303-534] pg/ml at 0. h and 19.7 [13.5-25.8] pg/ml at 6. h. The colostrum concentration was 12.3 [8.1-20.1] pg/ml at 6. h. The dexmedetomidine completely disappeared from both within 24. h. The calculated milk-to-plasma ratio at 6. h was 0.76 [0.57-0.86]. The relative infant dose was 0.034{\%} [0.020-0.062{\%}]. At dexmedetomidine discontinuation, the Richmond Agitation-Sedation Scale score was -2 (range,-4 to -1). During surgery, no patients complained of nausea, peritoneal irritation or afterbirth pain. Conclusions: The dexmedetomidine milk-to-plasma ratio did not exceed 1 in any participant, and the relative infant dose was very low. Maternal sedation using dexmedetomidine is unlikely to be harmful for the infant.",
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AU - Yoshimura, M.

AU - Kunisawa, T.

AU - Suno, Manabu

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AU - Kurosawa, A.

AU - Nakanishi, R.

AU - Aoki, K.

AU - Toriumi, T.

PY - 2017

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N2 - Background: Dexmedetomidine is a sedative agent with high α2-adrenoreceptor selectivity. We investigated intravenous Dexmedetomidine administration during scheduled cesarean delivery under neuraxial anesthesia; and concentration in the colostrum. Methods: Twenty-seven participants having elective cesarean delivery under combined spinal-epidural anesthesia were enrolled. After delivery and cord clamping, 6. μg/kg/h of intravenous dexmedetomidine was administered for 10. minutes, followed by a dose of 0.7. μg/kg/h until peritoneal closure. Sedation, vital signs and side effects were recorded. Blood and colostrum samples were collected from each participant at 6, 12, and 24. h after dexmedetomidine administration. Samples were analysed using liquid chromatography tandem-mass spectroscopy. Results: Colostrum samples were collected from 10 patients. The median [95% CI] plasma dexmedetomidine concentration was 333 [303-534] pg/ml at 0. h and 19.7 [13.5-25.8] pg/ml at 6. h. The colostrum concentration was 12.3 [8.1-20.1] pg/ml at 6. h. The dexmedetomidine completely disappeared from both within 24. h. The calculated milk-to-plasma ratio at 6. h was 0.76 [0.57-0.86]. The relative infant dose was 0.034% [0.020-0.062%]. At dexmedetomidine discontinuation, the Richmond Agitation-Sedation Scale score was -2 (range,-4 to -1). During surgery, no patients complained of nausea, peritoneal irritation or afterbirth pain. Conclusions: The dexmedetomidine milk-to-plasma ratio did not exceed 1 in any participant, and the relative infant dose was very low. Maternal sedation using dexmedetomidine is unlikely to be harmful for the infant.

AB - Background: Dexmedetomidine is a sedative agent with high α2-adrenoreceptor selectivity. We investigated intravenous Dexmedetomidine administration during scheduled cesarean delivery under neuraxial anesthesia; and concentration in the colostrum. Methods: Twenty-seven participants having elective cesarean delivery under combined spinal-epidural anesthesia were enrolled. After delivery and cord clamping, 6. μg/kg/h of intravenous dexmedetomidine was administered for 10. minutes, followed by a dose of 0.7. μg/kg/h until peritoneal closure. Sedation, vital signs and side effects were recorded. Blood and colostrum samples were collected from each participant at 6, 12, and 24. h after dexmedetomidine administration. Samples were analysed using liquid chromatography tandem-mass spectroscopy. Results: Colostrum samples were collected from 10 patients. The median [95% CI] plasma dexmedetomidine concentration was 333 [303-534] pg/ml at 0. h and 19.7 [13.5-25.8] pg/ml at 6. h. The colostrum concentration was 12.3 [8.1-20.1] pg/ml at 6. h. The dexmedetomidine completely disappeared from both within 24. h. The calculated milk-to-plasma ratio at 6. h was 0.76 [0.57-0.86]. The relative infant dose was 0.034% [0.020-0.062%]. At dexmedetomidine discontinuation, the Richmond Agitation-Sedation Scale score was -2 (range,-4 to -1). During surgery, no patients complained of nausea, peritoneal irritation or afterbirth pain. Conclusions: The dexmedetomidine milk-to-plasma ratio did not exceed 1 in any participant, and the relative infant dose was very low. Maternal sedation using dexmedetomidine is unlikely to be harmful for the infant.

KW - Colostrum

KW - Dexmedetomidine

KW - Milk-to-plasma ratio

KW - Relative infant dose

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