Intravascular lymphomatosis of the skin as a manifestation of recurrent B-cell lymphoma

Kenji Asagoe, Wataru Fujimoto, Tadashi Yoshino, Tomohiko Mannami, Yixuan Liu, Hiroko Kanzaki, Jirô Arata

Research output: Contribution to journalArticle

24 Citations (Scopus)

Abstract

Intravascular lymphomatosis (IVL) is a rare type of lymphoma with a poor prognosis. Its distinctive clinical and histopathologic features are generated by the proliferation of neoplastic mononuclear cells within blood vessels. We describe a patient with IVL of the skin as a manifestation of a recurrent diffuse large B-cell lymphoma of ureteral origin. Lymphoma cells were located both within the vessels and the parenchyma in an early cutaneous lesion. After recurrence in the skin, lymphoma cells gradually located only in the vascular lumina. This transition suggests that cells localized within the vessels were selected as a consequence of chemotherapy. Immunohistochemical examination revealed that the expression of surface adhesion molecules of lymphoma cells did not significantly change. The results of polymerase chain reaction revealed that the ureteral and cutaneous tumors were identical in clonality. Our findings suggest that conventional diffuse large B-cell lymphoma can change into IVL.

Original languageEnglish
JournalJournal of the American Academy of Dermatology
Volume48
Issue number2
DOIs
Publication statusPublished - Feb 1 2003

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B-Cell Lymphoma
Lymphoma
Skin
Lymphoma, Large B-Cell, Diffuse
Blood Vessels
Cell Adhesion Molecules
Recurrence
Drug Therapy
Polymerase Chain Reaction
Neoplasms

ASJC Scopus subject areas

  • Dermatology

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Intravascular lymphomatosis of the skin as a manifestation of recurrent B-cell lymphoma. / Asagoe, Kenji; Fujimoto, Wataru; Yoshino, Tadashi; Mannami, Tomohiko; Liu, Yixuan; Kanzaki, Hiroko; Arata, Jirô.

In: Journal of the American Academy of Dermatology, Vol. 48, No. 2, 01.02.2003.

Research output: Contribution to journalArticle

Asagoe, Kenji ; Fujimoto, Wataru ; Yoshino, Tadashi ; Mannami, Tomohiko ; Liu, Yixuan ; Kanzaki, Hiroko ; Arata, Jirô. / Intravascular lymphomatosis of the skin as a manifestation of recurrent B-cell lymphoma. In: Journal of the American Academy of Dermatology. 2003 ; Vol. 48, No. 2.
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