Intrauterine growth restriction caused by underlying congenital cytomegalovirus infection

Lenore Pereira, Matthew Petitt, Alex Fong, Mitsuru Tsuge, Takako Tabata, June Fang-Hoonver, Ekaterina Maidji, Martin Zydek, Yan Zhou, Naoki Inoue, Sanam Loghavi, Samuel Pepkowitz, Lawrence M. Kauvar, Dotun Ogunyemi

Research output: Contribution to journalArticle

52 Citations (Scopus)

Abstract

Background. Human cytomegalovirus (HCMV) is the major viral etiology of congenital infection and birth defects. Fetal transmission is high (30%-40%) in primary maternal infection, and symptomatic babies have permanent neurological, hearing, and vision defects. Recurrent infection is infrequently transmitted (2%) and largely asymptomatic. Congenital infection is also associated with intrauterine growth restriction (IUGR). Methods. To investigate possible underlyingHCMVinfection in cases of idiopathic IUGR,we studiedmaternal and cord sera and placentas from 19 pregnancies. Anti-HCMVantibodies, hypoxia-related factors, and cmvIL-10 weremeasuredinsera. Placental biopsyspecimenswere examined for viralDNA, expressionof infectedcell proteins, and pathology. Results. Among 7 IUGR cases, we identified 2 primary and 3 recurrent HCMV infections. Virus replicated in glandular epitheliumand lymphatic endotheliumin the decidua, cytotrophoblasts, and smoothmuscle cells in blood vessels of floating villi and the chorion. Large fibrinoids with avascular villi, edema, and inflammation were significantly increased. Detectionofviralproteinsintheamnioticepitheliumindicatedtransmissionin2cases ofIUGRwithprimaryinfectionand 3 asymptomatic recurrent infections. Conclusions. CongenitalHCMVinfectionimpairs placentaldevelopmentand functions and shouldbe consideredas an underlying cause of IUGR, regardless of virus transmission to the fetus.

Original languageEnglish
Pages (from-to)1573-1584
Number of pages12
JournalJournal of Infectious Diseases
Volume209
Issue number10
DOIs
Publication statusPublished - May 15 2014
Externally publishedYes

Fingerprint

Cytomegalovirus Infections
Growth
Infection
Viruses
Chorion
Decidua
Asymptomatic Infections
Trophoblasts
Cytomegalovirus
Placenta
Hearing
Blood Vessels
Edema
Fetus
Mothers
Pathology
Inflammation
Pregnancy
Serum
Proteins

Keywords

  • amnion
  • blood vessels
  • chorion
  • congenital
  • fetus
  • HCMV
  • IUGR
  • placenta
  • pregnancy
  • villi

ASJC Scopus subject areas

  • Immunology and Allergy
  • Infectious Diseases

Cite this

Pereira, L., Petitt, M., Fong, A., Tsuge, M., Tabata, T., Fang-Hoonver, J., ... Ogunyemi, D. (2014). Intrauterine growth restriction caused by underlying congenital cytomegalovirus infection. Journal of Infectious Diseases, 209(10), 1573-1584. https://doi.org/10.1093/infdis/jiu019

Intrauterine growth restriction caused by underlying congenital cytomegalovirus infection. / Pereira, Lenore; Petitt, Matthew; Fong, Alex; Tsuge, Mitsuru; Tabata, Takako; Fang-Hoonver, June; Maidji, Ekaterina; Zydek, Martin; Zhou, Yan; Inoue, Naoki; Loghavi, Sanam; Pepkowitz, Samuel; Kauvar, Lawrence M.; Ogunyemi, Dotun.

In: Journal of Infectious Diseases, Vol. 209, No. 10, 15.05.2014, p. 1573-1584.

Research output: Contribution to journalArticle

Pereira, L, Petitt, M, Fong, A, Tsuge, M, Tabata, T, Fang-Hoonver, J, Maidji, E, Zydek, M, Zhou, Y, Inoue, N, Loghavi, S, Pepkowitz, S, Kauvar, LM & Ogunyemi, D 2014, 'Intrauterine growth restriction caused by underlying congenital cytomegalovirus infection', Journal of Infectious Diseases, vol. 209, no. 10, pp. 1573-1584. https://doi.org/10.1093/infdis/jiu019
Pereira, Lenore ; Petitt, Matthew ; Fong, Alex ; Tsuge, Mitsuru ; Tabata, Takako ; Fang-Hoonver, June ; Maidji, Ekaterina ; Zydek, Martin ; Zhou, Yan ; Inoue, Naoki ; Loghavi, Sanam ; Pepkowitz, Samuel ; Kauvar, Lawrence M. ; Ogunyemi, Dotun. / Intrauterine growth restriction caused by underlying congenital cytomegalovirus infection. In: Journal of Infectious Diseases. 2014 ; Vol. 209, No. 10. pp. 1573-1584.
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AU - Fang-Hoonver, June

AU - Maidji, Ekaterina

AU - Zydek, Martin

AU - Zhou, Yan

AU - Inoue, Naoki

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AU - Pepkowitz, Samuel

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AU - Ogunyemi, Dotun

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N2 - Background. Human cytomegalovirus (HCMV) is the major viral etiology of congenital infection and birth defects. Fetal transmission is high (30%-40%) in primary maternal infection, and symptomatic babies have permanent neurological, hearing, and vision defects. Recurrent infection is infrequently transmitted (2%) and largely asymptomatic. Congenital infection is also associated with intrauterine growth restriction (IUGR). Methods. To investigate possible underlyingHCMVinfection in cases of idiopathic IUGR,we studiedmaternal and cord sera and placentas from 19 pregnancies. Anti-HCMVantibodies, hypoxia-related factors, and cmvIL-10 weremeasuredinsera. Placental biopsyspecimenswere examined for viralDNA, expressionof infectedcell proteins, and pathology. Results. Among 7 IUGR cases, we identified 2 primary and 3 recurrent HCMV infections. Virus replicated in glandular epitheliumand lymphatic endotheliumin the decidua, cytotrophoblasts, and smoothmuscle cells in blood vessels of floating villi and the chorion. Large fibrinoids with avascular villi, edema, and inflammation were significantly increased. Detectionofviralproteinsintheamnioticepitheliumindicatedtransmissionin2cases ofIUGRwithprimaryinfectionand 3 asymptomatic recurrent infections. Conclusions. CongenitalHCMVinfectionimpairs placentaldevelopmentand functions and shouldbe consideredas an underlying cause of IUGR, regardless of virus transmission to the fetus.

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