Abstract
Expression levels of the novel tumor suppressor gene REIC/Dkk-3 are reduced in many human cancers. We have previously showed that an adenovirus vector carrying REIC/Dkk-3 (Ad-REIC) induced apoptosis of cancer cells selectively and exerted bystander antitumor effects via ER stress. We examined possible effects of Ad-REIC in a peritoneal dissemination model of scirrhous gastric carcinoma (SGC). Among various types of gastric cancer, SGC continues to be associated with the worst prognosis due to a high incidence of metastases in the peritoneal cavity. We found that a single intraperitoneal injection of Ad-REIC suppressed tumor dissemination and disease progression. Immunomodulation by Ad-REIC led to recruitment of natural killer cells inside tumor nodules. We conclude that Ad-REIC gene therapy may be a potential tool in combinatorial approaches to achieve curative effects in SGC.
| Original language | English |
|---|---|
| Pages (from-to) | 989-995 |
| Number of pages | 7 |
| Journal | Oncology Reports |
| Volume | 25 |
| Issue number | 4 |
| DOIs | |
| Publication status | Published - Apr 2011 |
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Keywords
- Gene therapy
- REIC/Dkk-3
- Scirrhous gastric carcinoma
ASJC Scopus subject areas
- Cancer Research
- Oncology
Cite this
Intraperitoneal administration of an adenovirus vector carrying REIC/Dkk-3 suppresses peritoneal dissemination of scirrhous gastric carcinoma. / Than, Swe Swe; Kataoka, Ken; Sakaguchi, Masakiyo; Murata, Hitoshi; Abarzua, Fernando; Taketa, Chika; Du, Gang; Yashiro, Masakazu; Yanagihara, Kazuyoshi; Nasu, Yasutomo; Kumon, Hiromi; Huh, Nam Ho.
In: Oncology Reports, Vol. 25, No. 4, 04.2011, p. 989-995.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Intraperitoneal administration of an adenovirus vector carrying REIC/Dkk-3 suppresses peritoneal dissemination of scirrhous gastric carcinoma
AU - Than, Swe Swe
AU - Kataoka, Ken
AU - Sakaguchi, Masakiyo
AU - Murata, Hitoshi
AU - Abarzua, Fernando
AU - Taketa, Chika
AU - Du, Gang
AU - Yashiro, Masakazu
AU - Yanagihara, Kazuyoshi
AU - Nasu, Yasutomo
AU - Kumon, Hiromi
AU - Huh, Nam Ho
PY - 2011/4
Y1 - 2011/4
N2 - Expression levels of the novel tumor suppressor gene REIC/Dkk-3 are reduced in many human cancers. We have previously showed that an adenovirus vector carrying REIC/Dkk-3 (Ad-REIC) induced apoptosis of cancer cells selectively and exerted bystander antitumor effects via ER stress. We examined possible effects of Ad-REIC in a peritoneal dissemination model of scirrhous gastric carcinoma (SGC). Among various types of gastric cancer, SGC continues to be associated with the worst prognosis due to a high incidence of metastases in the peritoneal cavity. We found that a single intraperitoneal injection of Ad-REIC suppressed tumor dissemination and disease progression. Immunomodulation by Ad-REIC led to recruitment of natural killer cells inside tumor nodules. We conclude that Ad-REIC gene therapy may be a potential tool in combinatorial approaches to achieve curative effects in SGC.
AB - Expression levels of the novel tumor suppressor gene REIC/Dkk-3 are reduced in many human cancers. We have previously showed that an adenovirus vector carrying REIC/Dkk-3 (Ad-REIC) induced apoptosis of cancer cells selectively and exerted bystander antitumor effects via ER stress. We examined possible effects of Ad-REIC in a peritoneal dissemination model of scirrhous gastric carcinoma (SGC). Among various types of gastric cancer, SGC continues to be associated with the worst prognosis due to a high incidence of metastases in the peritoneal cavity. We found that a single intraperitoneal injection of Ad-REIC suppressed tumor dissemination and disease progression. Immunomodulation by Ad-REIC led to recruitment of natural killer cells inside tumor nodules. We conclude that Ad-REIC gene therapy may be a potential tool in combinatorial approaches to achieve curative effects in SGC.
KW - Gene therapy
KW - REIC/Dkk-3
KW - Scirrhous gastric carcinoma
UR - http://www.scopus.com/inward/record.url?scp=79952203032&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=79952203032&partnerID=8YFLogxK
U2 - 10.3892/or.2011.1149
DO - 10.3892/or.2011.1149
M3 - Article
C2 - 21249317
AN - SCOPUS:79952203032
VL - 25
SP - 989
EP - 995
JO - Oncology Reports
JF - Oncology Reports
SN - 1021-335X
IS - 4
ER -