Intraperitoneal administration of an adenovirus vector carrying REIC/Dkk-3 suppresses peritoneal dissemination of scirrhous gastric carcinoma

Swe Swe Than; Ken Kataoka; Masakiyo Sakaguchi; Hitoshi Murata; Fernando Abarzua; Chika Taketa; Gang Du; Masakazu Yashiro; Kazuyoshi Yanagihara; Yasutomo Nasu; Hiromi Kumon; Nam Ho Huh

doi:10.3892/or.2011.1149

Intraperitoneal administration of an adenovirus vector carrying REIC/Dkk-3 suppresses peritoneal dissemination of scirrhous gastric carcinoma

Swe Swe Than, Ken Kataoka, Masakiyo Sakaguchi, Hitoshi Murata, Fernando Abarzua, Chika Taketa, Gang Du, Masakazu Yashiro, Kazuyoshi Yanagihara, Yasutomo Nasu, Hiromi Kumon, Nam Ho Huh

Research output: Contribution to journal › Article › peer-review

24 Citations (Scopus)

Abstract

Expression levels of the novel tumor suppressor gene REIC/Dkk-3 are reduced in many human cancers. We have previously showed that an adenovirus vector carrying REIC/Dkk-3 (Ad-REIC) induced apoptosis of cancer cells selectively and exerted bystander antitumor effects via ER stress. We examined possible effects of Ad-REIC in a peritoneal dissemination model of scirrhous gastric carcinoma (SGC). Among various types of gastric cancer, SGC continues to be associated with the worst prognosis due to a high incidence of metastases in the peritoneal cavity. We found that a single intraperitoneal injection of Ad-REIC suppressed tumor dissemination and disease progression. Immunomodulation by Ad-REIC led to recruitment of natural killer cells inside tumor nodules. We conclude that Ad-REIC gene therapy may be a potential tool in combinatorial approaches to achieve curative effects in SGC.

Original language	English
Pages (from-to)	989-995
Number of pages	7
Journal	Oncology reports
Volume	25
Issue number	4
DOIs	https://doi.org/10.3892/or.2011.1149
Publication status	Published - Apr 2011

Keywords

Gene therapy
REIC/Dkk-3
Scirrhous gastric carcinoma

ASJC Scopus subject areas

Oncology
Cancer Research

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.3892/or.2011.1149

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Than, S. S., Kataoka, K., Sakaguchi, M., Murata, H., Abarzua, F., Taketa, C., Du, G., Yashiro, M., Yanagihara, K., Nasu, Y., Kumon, H., & Huh, N. H. (2011). Intraperitoneal administration of an adenovirus vector carrying REIC/Dkk-3 suppresses peritoneal dissemination of scirrhous gastric carcinoma. Oncology reports, 25(4), 989-995. https://doi.org/10.3892/or.2011.1149

Intraperitoneal administration of an adenovirus vector carrying REIC/Dkk-3 suppresses peritoneal dissemination of scirrhous gastric carcinoma. / Than, Swe Swe; Kataoka, Ken; Sakaguchi, Masakiyo ; Murata, Hitoshi; Abarzua, Fernando; Taketa, Chika; Du, Gang; Yashiro, Masakazu; Yanagihara, Kazuyoshi; Nasu, Yasutomo; Kumon, Hiromi; Huh, Nam Ho.

In: Oncology reports, Vol. 25, No. 4, 04.2011, p. 989-995.

Research output: Contribution to journal › Article › peer-review

Than, Swe Swe ; Kataoka, Ken ; Sakaguchi, Masakiyo ; Murata, Hitoshi ; Abarzua, Fernando ; Taketa, Chika ; Du, Gang ; Yashiro, Masakazu ; Yanagihara, Kazuyoshi ; Nasu, Yasutomo ; Kumon, Hiromi ; Huh, Nam Ho. / Intraperitoneal administration of an adenovirus vector carrying REIC/Dkk-3 suppresses peritoneal dissemination of scirrhous gastric carcinoma. In: Oncology reports. 2011 ; Vol. 25, No. 4. pp. 989-995.

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abstract = "Expression levels of the novel tumor suppressor gene REIC/Dkk-3 are reduced in many human cancers. We have previously showed that an adenovirus vector carrying REIC/Dkk-3 (Ad-REIC) induced apoptosis of cancer cells selectively and exerted bystander antitumor effects via ER stress. We examined possible effects of Ad-REIC in a peritoneal dissemination model of scirrhous gastric carcinoma (SGC). Among various types of gastric cancer, SGC continues to be associated with the worst prognosis due to a high incidence of metastases in the peritoneal cavity. We found that a single intraperitoneal injection of Ad-REIC suppressed tumor dissemination and disease progression. Immunomodulation by Ad-REIC led to recruitment of natural killer cells inside tumor nodules. We conclude that Ad-REIC gene therapy may be a potential tool in combinatorial approaches to achieve curative effects in SGC.",

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AU - Du, Gang

AU - Yashiro, Masakazu

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AB - Expression levels of the novel tumor suppressor gene REIC/Dkk-3 are reduced in many human cancers. We have previously showed that an adenovirus vector carrying REIC/Dkk-3 (Ad-REIC) induced apoptosis of cancer cells selectively and exerted bystander antitumor effects via ER stress. We examined possible effects of Ad-REIC in a peritoneal dissemination model of scirrhous gastric carcinoma (SGC). Among various types of gastric cancer, SGC continues to be associated with the worst prognosis due to a high incidence of metastases in the peritoneal cavity. We found that a single intraperitoneal injection of Ad-REIC suppressed tumor dissemination and disease progression. Immunomodulation by Ad-REIC led to recruitment of natural killer cells inside tumor nodules. We conclude that Ad-REIC gene therapy may be a potential tool in combinatorial approaches to achieve curative effects in SGC.

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Intraperitoneal administration of an adenovirus vector carrying REIC/Dkk-3 suppresses peritoneal dissemination of scirrhous gastric carcinoma

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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