Intraparenchymal allografts in the mouse brain in relation to immunocytochemical identification of T lymphocyte subsets

Isao Date, Koki Kawamura, Hiroyuki Nakashima, Katsuhiko Ono, Akira Nishimoto

Research output: Contribution to journalArticle

20 Citations (Scopus)

Abstract

In a study of intracerebellar allografts of mice brainstem anlagen (embryonic day 12-14), we examined immunocytochemically the expression of two different types of T lymphocytes in and around the grafts. Helper/inducer and cytotoxic/suppressor T cells were identified with anti-L3T4 and anti-Lyt-2 monoclonal antibodies, respectively. Allografts into major histocompatibility complex (MHC)-compatible recipients showed no histological signs of rejection such as marked neovascularization and cellular infiltrates even 6 months after transplantation, but those into MHC-incompatible recipients generally had rejection reactions within one month after transplantation. In the latter cases, the L3T4/Lyt-2 ratio for the T lymphocytes in the infiltrates of the grafts was 1.03±0.14 (mean ± S.D.), suggesting that both helper/inducer and cytotoxic/suppressor T cells may play important roles in the mediation of intraparenchymal brain allograft rejection.

Original languageEnglish
Pages (from-to)17-20
Number of pages4
JournalNeuroscience Letters
Volume86
Issue number1
DOIs
Publication statusPublished - Mar 21 1988

Keywords

  • Allograft
  • Immunocytochemistry
  • Mouse
  • Neural transplantation
  • Rejection
  • T cell subset

ASJC Scopus subject areas

  • Neuroscience(all)

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