Intraocular Pressure Elevation after Injection of Triamcinolone Acetonide: A Multicenter Retrospective Case-Control Study

Masaru Inatani, Keiichiro Iwao, Takahiro Kawaji, Yoshio Hirano, Yuichiro Ogura, Kazuyuki Hirooka, Fumio Shiraga, Yoriko Nakanishi, Hiroyuki Yamamoto, Akira Negi, Yuka Shimonagano, Taiji Sakamoto, Chieko Shima, Miyo Matsumura, Hidenobu Tanihara

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Abstract

Purpose: To determine the risk factors for intraocular pressure (IOP) elevation after the injection of triamcinolone acetonide (TA). Design: Retrospective interventional case-control study. Methods: setting: Multicenter. patient population: Four hundred and twenty-seven patients. observation procedures: Intraocular pressure levels after TA treatment by the sub-Tenon capsule injection (STI; 12 mg, 20 mg, or 40 mg), intravitreal injection (IVI; 4 mg or 8 mg), or the combination of STI (20 mg) and IVI (4 mg), and IOP levels after two TA treatments. main outcome measure: Risk factors for IOP levels of 24 mm Hg or higher. Results: Younger age (hazards ratio [HR], 0.96/year; P < .0001), IVI (HR, 1.89/year; P < .0001), and higher baseline IOP (HR, 1.15/mm Hg; P = .003) were identified as risk factors. Dose dependency was shown in STI-treated eyes (HR, 1.07/mg; P = .0006), as well as after IVI (HR, 1.64/mg; P = .013). The combination of STI and IVI was a significant risk factor (HR, 2.27; P = .003) compared with STI alone. In eyes receiving two TA treatments, IVI (HR, 2.60; P = .010), higher IOP elevation after the first injection (HR, 1.18/mm Hg; P = .011), and increased dosage of STI (HR, 1.07/mm Hg; P = .033) were risk factors. Conclusions: Younger age, higher baseline IOP, IVI, and increased TA dosage were associated with TA-induced IOP elevation. IOP elevation after repeated TA injection was frequently associated with eyes treated with IVI, high IOP elevation after the first injection, and high doses of STI.

Original languageEnglish
Pages (from-to)676-681.e1
JournalAmerican Journal of Ophthalmology
Volume145
Issue number4
DOIs
Publication statusPublished - Apr 2008

ASJC Scopus subject areas

  • Ophthalmology

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    Inatani, M., Iwao, K., Kawaji, T., Hirano, Y., Ogura, Y., Hirooka, K., Shiraga, F., Nakanishi, Y., Yamamoto, H., Negi, A., Shimonagano, Y., Sakamoto, T., Shima, C., Matsumura, M., & Tanihara, H. (2008). Intraocular Pressure Elevation after Injection of Triamcinolone Acetonide: A Multicenter Retrospective Case-Control Study. American Journal of Ophthalmology, 145(4), 676-681.e1. https://doi.org/10.1016/j.ajo.2007.12.010