Abstract
Intraneural perineurioma is a rare peripheral nerve sheath tumor consisting of intraneural proliferation of neoplastic perineurial cells. Clinical and pathological findings of a perineurioma involving the ulnar nerve is presented. A 7-year-old girl presented with a 2 year history of weakness and atrophy of the right hand muscles. Physical examination and imaging study revealed a pea-sized tumor in the ulnar side of the right forearm. At surgery, a fusiform swelling of the ulinar nerve was found and an excisional biopsy of the lesion was performed. Light microscopy revealed numerous whorls consisting of concentric layers of spindle cells encircling the nerve fibers. The proliferating cells were immunoreactive for vimentin, epithelial membrane antigen and glucose transporter protein 1 (Glut1), but negative for S-100 protein and CD34. Ultrastruclural examination revealed features of perineurial cell differentiation. The current study suggests that Glut1 is a useful marker of intraneural perineurioma.
| Original language | English |
|---|---|
| Pages (from-to) | 371-375 |
| Number of pages | 5 |
| Journal | Pathology International |
| Volume | 54 |
| Issue number | 5 |
| DOIs | |
| Publication status | Published - May 2004 |
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Keywords
- Glucose transporter protein 1
- Intraneural perineurioma
- Peripheral nerve sheath tumor
ASJC Scopus subject areas
- Pathology and Forensic Medicine
Cite this
Intraneural perineurioma involving the ulnar nerve. / Hamazaki, Shuji; Fujiwara, Kazuo; Okada, Shigeru.
In: Pathology International, Vol. 54, No. 5, 05.2004, p. 371-375.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Intraneural perineurioma involving the ulnar nerve
AU - Hamazaki, Shuji
AU - Fujiwara, Kazuo
AU - Okada, Shigeru
PY - 2004/5
Y1 - 2004/5
N2 - Intraneural perineurioma is a rare peripheral nerve sheath tumor consisting of intraneural proliferation of neoplastic perineurial cells. Clinical and pathological findings of a perineurioma involving the ulnar nerve is presented. A 7-year-old girl presented with a 2 year history of weakness and atrophy of the right hand muscles. Physical examination and imaging study revealed a pea-sized tumor in the ulnar side of the right forearm. At surgery, a fusiform swelling of the ulinar nerve was found and an excisional biopsy of the lesion was performed. Light microscopy revealed numerous whorls consisting of concentric layers of spindle cells encircling the nerve fibers. The proliferating cells were immunoreactive for vimentin, epithelial membrane antigen and glucose transporter protein 1 (Glut1), but negative for S-100 protein and CD34. Ultrastruclural examination revealed features of perineurial cell differentiation. The current study suggests that Glut1 is a useful marker of intraneural perineurioma.
AB - Intraneural perineurioma is a rare peripheral nerve sheath tumor consisting of intraneural proliferation of neoplastic perineurial cells. Clinical and pathological findings of a perineurioma involving the ulnar nerve is presented. A 7-year-old girl presented with a 2 year history of weakness and atrophy of the right hand muscles. Physical examination and imaging study revealed a pea-sized tumor in the ulnar side of the right forearm. At surgery, a fusiform swelling of the ulinar nerve was found and an excisional biopsy of the lesion was performed. Light microscopy revealed numerous whorls consisting of concentric layers of spindle cells encircling the nerve fibers. The proliferating cells were immunoreactive for vimentin, epithelial membrane antigen and glucose transporter protein 1 (Glut1), but negative for S-100 protein and CD34. Ultrastruclural examination revealed features of perineurial cell differentiation. The current study suggests that Glut1 is a useful marker of intraneural perineurioma.
KW - Glucose transporter protein 1
KW - Intraneural perineurioma
KW - Peripheral nerve sheath tumor
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U2 - 10.1111/j.1440-1827.2004.01634.x
DO - 10.1111/j.1440-1827.2004.01634.x
M3 - Article
C2 - 15086844
AN - SCOPUS:2642516383
VL - 54
SP - 371
EP - 375
JO - Pathology International
JF - Pathology International
SN - 1320-5463
IS - 5
ER -