Intraneural perineurioma involving the ulnar nerve

Shuji Hamazaki, Kazuo Fujiwara, Shigeru Okada

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

Intraneural perineurioma is a rare peripheral nerve sheath tumor consisting of intraneural proliferation of neoplastic perineurial cells. Clinical and pathological findings of a perineurioma involving the ulnar nerve is presented. A 7-year-old girl presented with a 2 year history of weakness and atrophy of the right hand muscles. Physical examination and imaging study revealed a pea-sized tumor in the ulnar side of the right forearm. At surgery, a fusiform swelling of the ulinar nerve was found and an excisional biopsy of the lesion was performed. Light microscopy revealed numerous whorls consisting of concentric layers of spindle cells encircling the nerve fibers. The proliferating cells were immunoreactive for vimentin, epithelial membrane antigen and glucose transporter protein 1 (Glut1), but negative for S-100 protein and CD34. Ultrastruclural examination revealed features of perineurial cell differentiation. The current study suggests that Glut1 is a useful marker of intraneural perineurioma.

Original languageEnglish
Pages (from-to)371-375
Number of pages5
JournalPathology International
Volume54
Issue number5
DOIs
Publication statusPublished - May 2004

Keywords

  • Glucose transporter protein 1
  • Intraneural perineurioma
  • Peripheral nerve sheath tumor

ASJC Scopus subject areas

  • Pathology and Forensic Medicine

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