Intramyocardial CD34+ cell transplantation combined with off-pump coronary artery bypass grafting.

Hiroshi Nagamine, G. Watanabe, Shintarou Shiobara, Hirofumi Takemura, Sadahiko Arai, Shigeyuki Tomita

Research output: Contribution to journalArticlepeer-review

9 Citations (Scopus)

Abstract

This report describes a new therapeutic approach for severe ischemic heart disease, intramyocardial transplantation of autologous bone marrow-derived CD34 + cells combined with off-pump coronary artery bypass grafting (CABG). CD34 is widely known as a cell surface antigen expressed on hematopoietic stem cells, and recent experimental studies have shown that CD34 + cells include endothelial progenitor cells. We used the Isolex 300i magnetic cell selection system to separate CD34 + cells from bone marrow cells. This report describes the first case treated with the combination of off-pump CABG and cell transplantation for therapeutic angiogenesis and myocardial regeneration. The transplantation of autologous bone marrow-derived CD34 + cells improved perfusion of the ungraftable ischemic area.

Original languageEnglish
Pages (from-to)E285-287
JournalThe heart surgery forum
Volume7
Issue number4
Publication statusPublished - 2004

ASJC Scopus subject areas

  • Surgery
  • Cardiology and Cardiovascular Medicine

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