Intramedullary spinal cord recurrence after high-dose chemotherapy and autologous peripheral blood progenitor cell transplantation for limited-disease small cell lung cancer

Nobukazu Fujimoto, Akio Hiraki, Hiroshi Ueoka, Katsuyuki Kiura, Akihiro Bessho, Ichiro Takata, Yasushi Hiramatsu, Kazuma Ikeda, Mine Harada

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

Intramedullary spinal cord metastasis is very rare in small-cell lung cancer (SCLC), and develops in only 2% of neurological disorders associated with SCLC according to previous reports. We describe here a patient with SCLC who developed intramedullary spinal cord recurrence after high-dose chemotherapy (HDCT) followed by autologous blood progenitor cell transplantation (ABPCT). A 59-year-old Japanese male was referred to us for diagnosis and treatment of an abnormal shadow on a chest radiograph. Based on transbronchial biopsy and staging procedures, he was diagnosed with limited-disease (LD)-SCLC. He received concurrent chemoradiotherapy followed by late intensification with HDCT supported by ABPCT. He achieved complete response and was discharged after receiving prophylactic cranial irradiation (PCI). However 6 months later, he noticed rapidly progressive weakness of the left lower extremity and bowel/bladder dysfunction. Magnetic resonance imaging (MRI) of the spinal cord disclosed an intramedullary tumor exhibiting an enhancement effect with Gd-DTPA at the 11-12th level of the thoracic vertebra. Immediately, radiotherapy to the spinal cord metastasis was given at a dose of 30 Gy, and his neurological disorders were completely resolved. At this time of reporting, he is doing well without recurrence. This case indicates that intramedullary spinal cord is one of the recurrence sites implicated after HDCT and PCI in LD-SCLC. (C) 2000 Elsevier Science Ireland Ltd.

Original languageEnglish
Pages (from-to)145-148
Number of pages4
JournalLung Cancer
Volume30
Issue number2
DOIs
Publication statusPublished - 2000

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Cell Transplantation
Small Cell Lung Carcinoma
Blood Cells
Spinal Cord
Stem Cells
Recurrence
Drug Therapy
Cranial Irradiation
Nervous System Diseases
Neoplasm Metastasis
Thoracic Vertebrae
Gadolinium DTPA
Chemoradiotherapy
Lower Extremity
Urinary Bladder
Radiotherapy
Thorax
Magnetic Resonance Imaging
Biopsy
Neoplasms

Keywords

  • Autologous peripheral blood progenitor cell transplantation
  • High-dose chemotherapy (HDCT)
  • Intramedullary metastasis
  • Small cell lung cancer
  • Spinal cord metastasis

ASJC Scopus subject areas

  • Oncology

Cite this

Intramedullary spinal cord recurrence after high-dose chemotherapy and autologous peripheral blood progenitor cell transplantation for limited-disease small cell lung cancer. / Fujimoto, Nobukazu; Hiraki, Akio; Ueoka, Hiroshi; Kiura, Katsuyuki; Bessho, Akihiro; Takata, Ichiro; Hiramatsu, Yasushi; Ikeda, Kazuma; Harada, Mine.

In: Lung Cancer, Vol. 30, No. 2, 2000, p. 145-148.

Research output: Contribution to journalArticle

Fujimoto, Nobukazu ; Hiraki, Akio ; Ueoka, Hiroshi ; Kiura, Katsuyuki ; Bessho, Akihiro ; Takata, Ichiro ; Hiramatsu, Yasushi ; Ikeda, Kazuma ; Harada, Mine. / Intramedullary spinal cord recurrence after high-dose chemotherapy and autologous peripheral blood progenitor cell transplantation for limited-disease small cell lung cancer. In: Lung Cancer. 2000 ; Vol. 30, No. 2. pp. 145-148.
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