Intralesional steroid injection to prevent stricture after endoscopic submucosal dissection for esophageal cancer

A controlled prospective study

N. Hanaoka, R. Ishihara, Y. Takeuchi, N. Uedo, K. Higashino, T. Ohta, Hiromitsu Kanzaki, M. Hanafusa, K. Nagai, F. Matsui, H. Iishi, M. Tatsuta, Y. Ito

Research output: Contribution to journalArticle

124 Citations (Scopus)

Abstract

Background and study aims: The frequency of stricture after endoscopic submucosal dissection (ESD) for esophageal squamous cell carcinoma with a mucosal defect involving more than three-quarters of the circumference is 70%-90%. Stricture decreases quality of life and requires multiple endoscopic balloon dilation (EBD) sessions. We investigated the efficacy and safety of a single session of intralesional steroid injections to prevent post-ESD stricture. Patients and methods: We conducted a prospective study on 30 patients with esophageal squamous cell carcinoma treated by ESD, who had a more than three-quarter but less than whole circumferential defect. A single session of intralesional steroid injections was undertaken immediately after ESD. Esophagogastroduodenoscopy was performed whenever patients reported dysphagia and 2 months after ESD in patients without dysphagia. Results were compared with a historical control group of 29 patients who underwent ESD without intralesional steroid injection. The primary endpoint was the post-ESD stricture rate. Secondary endpoints were the number of EBD sessions and the complication rate. Results: Compared with the historical control group, the study group had a significantly lower stricture rate (10%, 3/30 patients vs. 66%, 19/29 patients; P

Original languageEnglish
Pages (from-to)1007-1011
Number of pages5
JournalEndoscopy
Volume44
Issue number11
DOIs
Publication statusPublished - 2012
Externally publishedYes

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Intralesional Injections
Esophageal Neoplasms
Pathologic Constriction
Steroids
Prospective Studies
Deglutition Disorders
Dilatation
Digestive System Endoscopy
Control Groups
Endoscopic Mucosal Resection
Quality of Life
Safety

ASJC Scopus subject areas

  • Gastroenterology

Cite this

Intralesional steroid injection to prevent stricture after endoscopic submucosal dissection for esophageal cancer : A controlled prospective study. / Hanaoka, N.; Ishihara, R.; Takeuchi, Y.; Uedo, N.; Higashino, K.; Ohta, T.; Kanzaki, Hiromitsu; Hanafusa, M.; Nagai, K.; Matsui, F.; Iishi, H.; Tatsuta, M.; Ito, Y.

In: Endoscopy, Vol. 44, No. 11, 2012, p. 1007-1011.

Research output: Contribution to journalArticle

Hanaoka, N, Ishihara, R, Takeuchi, Y, Uedo, N, Higashino, K, Ohta, T, Kanzaki, H, Hanafusa, M, Nagai, K, Matsui, F, Iishi, H, Tatsuta, M & Ito, Y 2012, 'Intralesional steroid injection to prevent stricture after endoscopic submucosal dissection for esophageal cancer: A controlled prospective study', Endoscopy, vol. 44, no. 11, pp. 1007-1011. https://doi.org/10.1055/s-0032-1310107
Hanaoka, N. ; Ishihara, R. ; Takeuchi, Y. ; Uedo, N. ; Higashino, K. ; Ohta, T. ; Kanzaki, Hiromitsu ; Hanafusa, M. ; Nagai, K. ; Matsui, F. ; Iishi, H. ; Tatsuta, M. ; Ito, Y. / Intralesional steroid injection to prevent stricture after endoscopic submucosal dissection for esophageal cancer : A controlled prospective study. In: Endoscopy. 2012 ; Vol. 44, No. 11. pp. 1007-1011.
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