Intrahepatic mRNA levels of type I interferon receptor and interferon-stimulated genes in genotype 1b chronic hepatitis C: Association between IFNAR1 mRNA level and sustained response to interferon therapy

Hideaki Taniguchi, Yoshiaki Iwasaki, Akira Takahashi, Hiroyuki Shimomura, Akio Moriya, Piao Cheng Yu, Fumi Umeoka, Shin Ichi Fujioka, Norio Koide, Yasushi Shiratori

Research output: Contribution to journalArticlepeer-review

11 Citations (Scopus)

Abstract

Objective: The aim of this study was to determine the association between pretreatment intrahepatic mRNA levels of interferon receptor and interferon-stimulated genes and response to interferon therapy for genotype 1b chronic hepatitis C. Methods: Forty-four patients with genotype 1b chronic hepatitis C who underwent liver biopsy and then received interferon therapy participated in this study. Pretreatment intrahepatic mRNA levels of interferon receptor genes (IFNAR1, IFNAR2b, and IFNAR2c) and interferon-stimulated genes (OAS1 and PKR) were quantified by competitive polymerase chain reaction. Results: In the genes examined, only IFNAR1 mRNA level was significantly higher in patients with sustained virological and biochemical response to interferon therapy versus those with nonsustained response (p < 0.01). Moreover, mRNA expression ratios of IFNAR1 to IFNAR2 were also significantly higher in patients with sustained virological and biochemical response to IFN therapy (p < 0.01 and p < 0.05, respectively). On the other hand, mRNA levels of IFNAR2b, IFNAR2c, and PKR were significantly higher in patients with histologically active or advanced liver rather than patients with mild or less advanced liver. Conclusions: High intrahepatic mRNA levels of IFNAR1 and mRNA ratio of IFNAR1 to IFNAR2 before treatment may be associated with a favorable response to interferon therapy.

Original languageEnglish
Pages (from-to)32-39
Number of pages8
JournalIntervirology
Volume50
Issue number1
DOIs
Publication statusPublished - Dec 2006

Keywords

  • Chronic hepatitis C
  • Genotype 1b
  • Interferon receptor
  • Interferon therapy
  • Interferon-stimulated gene

ASJC Scopus subject areas

  • Virology
  • Infectious Diseases

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