Intracranial self-stimulation-reward induces neurite extension in PC12m3 cells and activation of the p38 MAPK pathway

Yutaka Gomita, Satoru Esumi, Naoya Sugiyama, Yoshihisa Kitamura, Yoshihisa Koike, Hirotoshi Motoda, Toshiaki Sendo, Yoshio Kano

Research output: Contribution to journal › Article

3 Citations (Scopus)

Abstract

Factors that trigger emotional expression may be divided into two patterns according to the type of motivation, acquiring reward (pleasure) and avoiding aversion (punishment). Repeated exposure to certain external stimuli accompanied by aberrant motivation may produce psychiatric diseases such as bipolar disorder and addiction via dysregulation of the central nervous system. However, neurobiological underpinnings of such diseases have not been clarified, especially at the neuronal level. In the present study, plasma from rats undergoing intracranial self-stimulation (ICSS) produced neurite outgrowth in PC12-variant cells (PC12m3). Stimulated PC12m3 cells also exhibited heightened activity of the p38 MAPK pathway. These findings indicate that reward states lead to not only morphological changes but also increases in p38 MAPK activity at the neuronal level in the central nervous system.

Original languageEnglish
Pages (from-to)78-84
Number of pages7
JournalNeuroscience Letters
Volume649
DOIs
Publication statusPublished - May 10 2017

Fingerprint

Self Stimulation
p38 Mitogen-Activated Protein Kinases
Neurites
Reward
Motivation
Central Nervous System
Pleasure
Punishment
PC12 Cells
Bipolar Disorder
Psychiatry
Neuronal Outgrowth

Keywords

  • Emotionality
  • Intracranial self-stimulation reward
  • Motivation
  • p38 MAPK pathway
  • PC12-variant cells

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Intracranial self-stimulation-reward induces neurite extension in PC12m3 cells and activation of the p38 MAPK pathway. / Gomita, Yutaka; Esumi, Satoru; Sugiyama, Naoya; Kitamura, Yoshihisa; Koike, Yoshihisa; Motoda, Hirotoshi; Sendo, Toshiaki; Kano, Yoshio.

In: Neuroscience Letters, Vol. 649, 10.05.2017, p. 78-84.

Research output: Contribution to journal › Article

Gomita, Y, Esumi, S, Sugiyama, N, Kitamura, Y, Koike, Y, Motoda, H, Sendo, T & Kano, Y 2017, 'Intracranial self-stimulation-reward induces neurite extension in PC12m3 cells and activation of the p38 MAPK pathway', Neuroscience Letters, vol. 649, pp. 78-84. https://doi.org/10.1016/j.neulet.2017.04.010
Gomita Y, Esumi S, Sugiyama N, Kitamura Y, Koike Y, Motoda H et al. Intracranial self-stimulation-reward induces neurite extension in PC12m3 cells and activation of the p38 MAPK pathway. Neuroscience Letters. 2017 May 10;649:78-84. https://doi.org/10.1016/j.neulet.2017.04.010
Gomita, Yutaka ; Esumi, Satoru ; Sugiyama, Naoya ; Kitamura, Yoshihisa ; Koike, Yoshihisa ; Motoda, Hirotoshi ; Sendo, Toshiaki ; Kano, Yoshio. / Intracranial self-stimulation-reward induces neurite extension in PC12m3 cells and activation of the p38 MAPK pathway. In: Neuroscience Letters. 2017 ; Vol. 649. pp. 78-84.
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AU - Kitamura, Yoshihisa

AU - Koike, Yoshihisa

AU - Motoda, Hirotoshi

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