Abstract
Factors that trigger emotional expression may be divided into two patterns according to the type of motivation, acquiring reward (pleasure) and avoiding aversion (punishment). Repeated exposure to certain external stimuli accompanied by aberrant motivation may produce psychiatric diseases such as bipolar disorder and addiction via dysregulation of the central nervous system. However, neurobiological underpinnings of such diseases have not been clarified, especially at the neuronal level. In the present study, plasma from rats undergoing intracranial self-stimulation (ICSS) produced neurite outgrowth in PC12-variant cells (PC12m3). Stimulated PC12m3 cells also exhibited heightened activity of the p38 MAPK pathway. These findings indicate that reward states lead to not only morphological changes but also increases in p38 MAPK activity at the neuronal level in the central nervous system.
Original language | English |
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Pages (from-to) | 78-84 |
Number of pages | 7 |
Journal | Neuroscience Letters |
Volume | 649 |
DOIs | |
Publication status | Published - May 10 2017 |
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Keywords
- Emotionality
- Intracranial self-stimulation reward
- Motivation
- p38 MAPK pathway
- PC12-variant cells
ASJC Scopus subject areas
- Neuroscience(all)
Cite this
Intracranial self-stimulation-reward induces neurite extension in PC12m3 cells and activation of the p38 MAPK pathway. / Gomita, Yutaka; Esumi, Satoru; Sugiyama, Naoya; Kitamura, Yoshihisa; Koike, Yoshihisa; Motoda, Hirotoshi; Sendo, Toshiaki; Kano, Yoshio.
In: Neuroscience Letters, Vol. 649, 10.05.2017, p. 78-84.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Intracranial self-stimulation-reward induces neurite extension in PC12m3 cells and activation of the p38 MAPK pathway
AU - Gomita, Yutaka
AU - Esumi, Satoru
AU - Sugiyama, Naoya
AU - Kitamura, Yoshihisa
AU - Koike, Yoshihisa
AU - Motoda, Hirotoshi
AU - Sendo, Toshiaki
AU - Kano, Yoshio
PY - 2017/5/10
Y1 - 2017/5/10
N2 - Factors that trigger emotional expression may be divided into two patterns according to the type of motivation, acquiring reward (pleasure) and avoiding aversion (punishment). Repeated exposure to certain external stimuli accompanied by aberrant motivation may produce psychiatric diseases such as bipolar disorder and addiction via dysregulation of the central nervous system. However, neurobiological underpinnings of such diseases have not been clarified, especially at the neuronal level. In the present study, plasma from rats undergoing intracranial self-stimulation (ICSS) produced neurite outgrowth in PC12-variant cells (PC12m3). Stimulated PC12m3 cells also exhibited heightened activity of the p38 MAPK pathway. These findings indicate that reward states lead to not only morphological changes but also increases in p38 MAPK activity at the neuronal level in the central nervous system.
AB - Factors that trigger emotional expression may be divided into two patterns according to the type of motivation, acquiring reward (pleasure) and avoiding aversion (punishment). Repeated exposure to certain external stimuli accompanied by aberrant motivation may produce psychiatric diseases such as bipolar disorder and addiction via dysregulation of the central nervous system. However, neurobiological underpinnings of such diseases have not been clarified, especially at the neuronal level. In the present study, plasma from rats undergoing intracranial self-stimulation (ICSS) produced neurite outgrowth in PC12-variant cells (PC12m3). Stimulated PC12m3 cells also exhibited heightened activity of the p38 MAPK pathway. These findings indicate that reward states lead to not only morphological changes but also increases in p38 MAPK activity at the neuronal level in the central nervous system.
KW - Emotionality
KW - Intracranial self-stimulation reward
KW - Motivation
KW - p38 MAPK pathway
KW - PC12-variant cells
UR - http://www.scopus.com/inward/record.url?scp=85017518663&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85017518663&partnerID=8YFLogxK
U2 - 10.1016/j.neulet.2017.04.010
DO - 10.1016/j.neulet.2017.04.010
M3 - Article
C2 - 28392359
AN - SCOPUS:85017518663
VL - 649
SP - 78
EP - 84
JO - Neuroscience Letters
JF - Neuroscience Letters
SN - 0304-3940
ER -