Intracerebroventricular injection of fusaric acid attenuates the anorexia by glucagon-like peptide-1 in the neonatal chick

T. Bungo, S. I. Kawakami, A. Ohgushi, K. Sashihara, Noboru Saito, K. Sugahara, S. Hasegawa, D. M. Denbow, M. Furuse

Research output: Contribution to journalArticle

23 Citations (Scopus)

Abstract

It is known that central injection of glucagon-like peptide-1 (GLP-1) suppresses feeding in rats and chicks, but the systems for GLP-1 are still open with special reference to the chick. The present study was done to determine whether a noradrenergic mechanism contributes to the anorexigenic effect of GLP-1 on the neonatal chick. Central administration of norepinephrine (NE) suppressed food intake with narcolepsy as GLP-1 in chicks. However, in spite of that dopamine (DA) did not affect food intake, coadministration of inhibitor of dopamine-β-hydroxylase (DBH), fusaric acid (FA), attenuated the suppressive effect of GLP-1 on feeding behavior. It is suggested that there may be the interactive relationships between GLP-1 and noradrenergic system in the neonatal chick.

Original languageEnglish
Pages (from-to)251-255
Number of pages5
JournalPharmacology Biochemistry and Behavior
Volume70
Issue number2-3
DOIs
Publication statusPublished - 2001
Externally publishedYes

Fingerprint

Fusaric Acid
Glucagon-Like Peptide 1
Anorexia
Injections
Dopamine
Eating
Narcolepsy
Feeding Behavior
Mixed Function Oxygenases
Rats
Norepinephrine

Keywords

  • Central nervous system
  • Chick
  • Food intake
  • Fusaric (5-butylpicolinic) acid
  • Glucagon-like peptide-1 (GLP-1)
  • Noradrenergic system

ASJC Scopus subject areas

  • Biochemistry
  • Behavioral Neuroscience
  • Pharmacology

Cite this

Intracerebroventricular injection of fusaric acid attenuates the anorexia by glucagon-like peptide-1 in the neonatal chick. / Bungo, T.; Kawakami, S. I.; Ohgushi, A.; Sashihara, K.; Saito, Noboru; Sugahara, K.; Hasegawa, S.; Denbow, D. M.; Furuse, M.

In: Pharmacology Biochemistry and Behavior, Vol. 70, No. 2-3, 2001, p. 251-255.

Research output: Contribution to journalArticle

Bungo, T. ; Kawakami, S. I. ; Ohgushi, A. ; Sashihara, K. ; Saito, Noboru ; Sugahara, K. ; Hasegawa, S. ; Denbow, D. M. ; Furuse, M. / Intracerebroventricular injection of fusaric acid attenuates the anorexia by glucagon-like peptide-1 in the neonatal chick. In: Pharmacology Biochemistry and Behavior. 2001 ; Vol. 70, No. 2-3. pp. 251-255.
@article{453ee88b2e59499182c1281aa70f8e9d,
title = "Intracerebroventricular injection of fusaric acid attenuates the anorexia by glucagon-like peptide-1 in the neonatal chick",
abstract = "It is known that central injection of glucagon-like peptide-1 (GLP-1) suppresses feeding in rats and chicks, but the systems for GLP-1 are still open with special reference to the chick. The present study was done to determine whether a noradrenergic mechanism contributes to the anorexigenic effect of GLP-1 on the neonatal chick. Central administration of norepinephrine (NE) suppressed food intake with narcolepsy as GLP-1 in chicks. However, in spite of that dopamine (DA) did not affect food intake, coadministration of inhibitor of dopamine-β-hydroxylase (DBH), fusaric acid (FA), attenuated the suppressive effect of GLP-1 on feeding behavior. It is suggested that there may be the interactive relationships between GLP-1 and noradrenergic system in the neonatal chick.",
keywords = "Central nervous system, Chick, Food intake, Fusaric (5-butylpicolinic) acid, Glucagon-like peptide-1 (GLP-1), Noradrenergic system",
author = "T. Bungo and Kawakami, {S. I.} and A. Ohgushi and K. Sashihara and Noboru Saito and K. Sugahara and S. Hasegawa and Denbow, {D. M.} and M. Furuse",
year = "2001",
doi = "10.1016/S0091-3057(01)00613-X",
language = "English",
volume = "70",
pages = "251--255",
journal = "Pharmacology, Biochemistry and Behavior",
issn = "0091-3057",
publisher = "Elsevier Inc.",
number = "2-3",

}

TY - JOUR

T1 - Intracerebroventricular injection of fusaric acid attenuates the anorexia by glucagon-like peptide-1 in the neonatal chick

AU - Bungo, T.

AU - Kawakami, S. I.

AU - Ohgushi, A.

AU - Sashihara, K.

AU - Saito, Noboru

AU - Sugahara, K.

AU - Hasegawa, S.

AU - Denbow, D. M.

AU - Furuse, M.

PY - 2001

Y1 - 2001

N2 - It is known that central injection of glucagon-like peptide-1 (GLP-1) suppresses feeding in rats and chicks, but the systems for GLP-1 are still open with special reference to the chick. The present study was done to determine whether a noradrenergic mechanism contributes to the anorexigenic effect of GLP-1 on the neonatal chick. Central administration of norepinephrine (NE) suppressed food intake with narcolepsy as GLP-1 in chicks. However, in spite of that dopamine (DA) did not affect food intake, coadministration of inhibitor of dopamine-β-hydroxylase (DBH), fusaric acid (FA), attenuated the suppressive effect of GLP-1 on feeding behavior. It is suggested that there may be the interactive relationships between GLP-1 and noradrenergic system in the neonatal chick.

AB - It is known that central injection of glucagon-like peptide-1 (GLP-1) suppresses feeding in rats and chicks, but the systems for GLP-1 are still open with special reference to the chick. The present study was done to determine whether a noradrenergic mechanism contributes to the anorexigenic effect of GLP-1 on the neonatal chick. Central administration of norepinephrine (NE) suppressed food intake with narcolepsy as GLP-1 in chicks. However, in spite of that dopamine (DA) did not affect food intake, coadministration of inhibitor of dopamine-β-hydroxylase (DBH), fusaric acid (FA), attenuated the suppressive effect of GLP-1 on feeding behavior. It is suggested that there may be the interactive relationships between GLP-1 and noradrenergic system in the neonatal chick.

KW - Central nervous system

KW - Chick

KW - Food intake

KW - Fusaric (5-butylpicolinic) acid

KW - Glucagon-like peptide-1 (GLP-1)

KW - Noradrenergic system

UR - http://www.scopus.com/inward/record.url?scp=0035159558&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0035159558&partnerID=8YFLogxK

U2 - 10.1016/S0091-3057(01)00613-X

DO - 10.1016/S0091-3057(01)00613-X

M3 - Article

VL - 70

SP - 251

EP - 255

JO - Pharmacology, Biochemistry and Behavior

JF - Pharmacology, Biochemistry and Behavior

SN - 0091-3057

IS - 2-3

ER -