TY - JOUR
T1 - Intracerebroventricular injection of fusaric acid attenuates the anorexia by glucagon-like peptide-1 in the neonatal chick
AU - Bungo, T.
AU - Kawakami, S. I.
AU - Ohgushi, A.
AU - Sashihara, K.
AU - Saito, N.
AU - Sugahara, K.
AU - Hasegawa, S.
AU - Denbow, D. M.
AU - Furuse, M.
N1 - Funding Information:
This study was supported by grant-in-aid for scientific research from the Ministry of Education, Science and Culture, Japan, by Kyowa Hakko Kogyo, Tokyo, Japan and Uehara Memorial Foundation, Japan.
PY - 2001
Y1 - 2001
N2 - It is known that central injection of glucagon-like peptide-1 (GLP-1) suppresses feeding in rats and chicks, but the systems for GLP-1 are still open with special reference to the chick. The present study was done to determine whether a noradrenergic mechanism contributes to the anorexigenic effect of GLP-1 on the neonatal chick. Central administration of norepinephrine (NE) suppressed food intake with narcolepsy as GLP-1 in chicks. However, in spite of that dopamine (DA) did not affect food intake, coadministration of inhibitor of dopamine-β-hydroxylase (DBH), fusaric acid (FA), attenuated the suppressive effect of GLP-1 on feeding behavior. It is suggested that there may be the interactive relationships between GLP-1 and noradrenergic system in the neonatal chick.
AB - It is known that central injection of glucagon-like peptide-1 (GLP-1) suppresses feeding in rats and chicks, but the systems for GLP-1 are still open with special reference to the chick. The present study was done to determine whether a noradrenergic mechanism contributes to the anorexigenic effect of GLP-1 on the neonatal chick. Central administration of norepinephrine (NE) suppressed food intake with narcolepsy as GLP-1 in chicks. However, in spite of that dopamine (DA) did not affect food intake, coadministration of inhibitor of dopamine-β-hydroxylase (DBH), fusaric acid (FA), attenuated the suppressive effect of GLP-1 on feeding behavior. It is suggested that there may be the interactive relationships between GLP-1 and noradrenergic system in the neonatal chick.
KW - Central nervous system
KW - Chick
KW - Food intake
KW - Fusaric (5-butylpicolinic) acid
KW - Glucagon-like peptide-1 (GLP-1)
KW - Noradrenergic system
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U2 - 10.1016/S0091-3057(01)00613-X
DO - 10.1016/S0091-3057(01)00613-X
M3 - Article
C2 - 11701195
AN - SCOPUS:0035159558
SN - 0091-3057
VL - 70
SP - 251
EP - 255
JO - Pharmacology, Biochemistry and Behavior
JF - Pharmacology, Biochemistry and Behavior
IS - 2-3
ER -