Intracellular calcium signaling systems in the pathophysiology of affective disorders

Shigeto Yamawaki; Ariyuki Kagaya; Yasutaka Tawara; Masatoshi Inagaki

doi:10.1016/S0024-3205(98)00125-8

Intracellular calcium signaling systems in the pathophysiology of affective disorders

Shigeto Yamawaki, Ariyuki Kagaya, Yasutaka Tawara, Masatoshi Inagaki

Research output: Contribution to journal › Article › peer-review

38 Citations (Scopus)

Abstract

In this paper, we show the importance of intracellular calcium (Ca²⁺) signaling systems in the pathophysiology of mood disorders based on our recent work. Patients with affective disorders appear to have an enhanced intracellular Ca²⁺ rise in response to serotonin. We have observed effects of antidepressant drugs on intracellular Ca²⁺ signaling in rat cultured neuronal cells and glioma cells, and found that acute application of several classes of antidepressant drugs inhibited intracellular Ca²⁺ signaling and Ca²⁺-related signaling. It is important to investigate the role of intracellular Ca²⁺ signaling system for an understanding of the pathophysiology of affective disorders.

Original language	English
Pages (from-to)	1665-1670
Number of pages	6
Journal	Life Sciences
Volume	62
Issue number	17-18
DOIs	https://doi.org/10.1016/S0024-3205(98)00125-8
Publication status	Published - Mar 27 1998
Externally published	Yes

Keywords

Affective disorders
Calcium
Clomipramine
Serotonin

ASJC Scopus subject areas

Biochemistry, Genetics and Molecular Biology(all)
Pharmacology, Toxicology and Pharmaceutics(all)

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10.1016/S0024-3205(98)00125-8

Cite this

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abstract = "In this paper, we show the importance of intracellular calcium (Ca2+) signaling systems in the pathophysiology of mood disorders based on our recent work. Patients with affective disorders appear to have an enhanced intracellular Ca2+ rise in response to serotonin. We have observed effects of antidepressant drugs on intracellular Ca2+ signaling in rat cultured neuronal cells and glioma cells, and found that acute application of several classes of antidepressant drugs inhibited intracellular Ca2+ signaling and Ca2+-related signaling. It is important to investigate the role of intracellular Ca2+ signaling system for an understanding of the pathophysiology of affective disorders.",

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AU - Yamawaki, Shigeto

AU - Kagaya, Ariyuki

AU - Tawara, Yasutaka

AU - Inagaki, Masatoshi

PY - 1998/3/27

Y1 - 1998/3/27

N2 - In this paper, we show the importance of intracellular calcium (Ca2+) signaling systems in the pathophysiology of mood disorders based on our recent work. Patients with affective disorders appear to have an enhanced intracellular Ca2+ rise in response to serotonin. We have observed effects of antidepressant drugs on intracellular Ca2+ signaling in rat cultured neuronal cells and glioma cells, and found that acute application of several classes of antidepressant drugs inhibited intracellular Ca2+ signaling and Ca2+-related signaling. It is important to investigate the role of intracellular Ca2+ signaling system for an understanding of the pathophysiology of affective disorders.

AB - In this paper, we show the importance of intracellular calcium (Ca2+) signaling systems in the pathophysiology of mood disorders based on our recent work. Patients with affective disorders appear to have an enhanced intracellular Ca2+ rise in response to serotonin. We have observed effects of antidepressant drugs on intracellular Ca2+ signaling in rat cultured neuronal cells and glioma cells, and found that acute application of several classes of antidepressant drugs inhibited intracellular Ca2+ signaling and Ca2+-related signaling. It is important to investigate the role of intracellular Ca2+ signaling system for an understanding of the pathophysiology of affective disorders.

KW - Affective disorders

KW - Calcium

KW - Clomipramine

KW - Serotonin

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ER -

Intracellular calcium signaling systems in the pathophysiology of affective disorders

Abstract

Keywords

ASJC Scopus subject areas

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