Intracellular calcium signaling systems in the pathophysiology of affective disorders

Shigeto Yamawaki, Ariyuki Kagaya, Yasutaka Tawara, Masatoshi Inagaki

Research output: Contribution to journalArticlepeer-review

38 Citations (Scopus)


In this paper, we show the importance of intracellular calcium (Ca2+) signaling systems in the pathophysiology of mood disorders based on our recent work. Patients with affective disorders appear to have an enhanced intracellular Ca2+ rise in response to serotonin. We have observed effects of antidepressant drugs on intracellular Ca2+ signaling in rat cultured neuronal cells and glioma cells, and found that acute application of several classes of antidepressant drugs inhibited intracellular Ca2+ signaling and Ca2+-related signaling. It is important to investigate the role of intracellular Ca2+ signaling system for an understanding of the pathophysiology of affective disorders.

Original languageEnglish
Pages (from-to)1665-1670
Number of pages6
JournalLife Sciences
Issue number17-18
Publication statusPublished - Mar 27 1998
Externally publishedYes


  • Affective disorders
  • Calcium
  • Clomipramine
  • Serotonin

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Pharmacology, Toxicology and Pharmaceutics(all)


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