Intracavernous injection of prostaglandin E1 is effective in patients with erectile dysfunction not responding to phosphodiseterase 5 inhibitors

Atsushi Nagai; Norihiro Kusumi; Hiromu Tsuboi; Kazushi Ishii; Takashi Saika; Yasutomo Nasu; Hiromi Kumon

Intracavernous injection of prostaglandin E₁ is effective in patients with erectile dysfunction not responding to phosphodiseterase 5 inhibitors

Atsushi Nagai, Norihiro Kusumi, Hiromu Tsuboi, Kazushi Ishii, Takashi Saika, Yasutomo Nasu, Hiromi Kumon

Research output: Contribution to journal › Article › peer-review

Abstract

We report on 64 patients who did not achieve erections adequate for satisfactory sexual intercourse from among a total of 243 patients who were prescribed PDE5 inhibitors for erectile dysfunction (ED). Intracavernous injection (ICI) of PGE₁ was performed in this non-responder group. An ICI of 20 or 40 mcg of PGE₁ in 1 ml saline was performed and the responses evaluated. Forty-nine out of 64 (77%) cases responded to 20 mcg of PGE₁. Forty mcg of PGE₁ was injected into the 15 non-responding cases, and 9 patients responded favorably. The overall effective rate was 58/64 (91 %). No major adverse effects were observed. Copyright

Original language	English
Pages (from-to)	279-280
Number of pages	2
Journal	Acta medica Okayama
Volume	59
Issue number	6
Publication status	Published - Dec 2005

Keywords

Erectile dysfunction
Intracavernous injection
PDE5 inhibitors
Prostaglandin E

ASJC Scopus subject areas

Biochemistry, Genetics and Molecular Biology(all)

Cite this

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abstract = "We report on 64 patients who did not achieve erections adequate for satisfactory sexual intercourse from among a total of 243 patients who were prescribed PDE5 inhibitors for erectile dysfunction (ED). Intracavernous injection (ICI) of PGE1 was performed in this non-responder group. An ICI of 20 or 40 mcg of PGE1 in 1 ml saline was performed and the responses evaluated. Forty-nine out of 64 (77%) cases responded to 20 mcg of PGE1. Forty mcg of PGE1 was injected into the 15 non-responding cases, and 9 patients responded favorably. The overall effective rate was 58/64 (91 %). No major adverse effects were observed. Copyright",

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AU - Nagai, Atsushi

AU - Kusumi, Norihiro

AU - Tsuboi, Hiromu

AU - Ishii, Kazushi

AU - Saika, Takashi

AU - Nasu, Yasutomo

AU - Kumon, Hiromi

PY - 2005/12

Y1 - 2005/12

N2 - We report on 64 patients who did not achieve erections adequate for satisfactory sexual intercourse from among a total of 243 patients who were prescribed PDE5 inhibitors for erectile dysfunction (ED). Intracavernous injection (ICI) of PGE1 was performed in this non-responder group. An ICI of 20 or 40 mcg of PGE1 in 1 ml saline was performed and the responses evaluated. Forty-nine out of 64 (77%) cases responded to 20 mcg of PGE1. Forty mcg of PGE1 was injected into the 15 non-responding cases, and 9 patients responded favorably. The overall effective rate was 58/64 (91 %). No major adverse effects were observed. Copyright

AB - We report on 64 patients who did not achieve erections adequate for satisfactory sexual intercourse from among a total of 243 patients who were prescribed PDE5 inhibitors for erectile dysfunction (ED). Intracavernous injection (ICI) of PGE1 was performed in this non-responder group. An ICI of 20 or 40 mcg of PGE1 in 1 ml saline was performed and the responses evaluated. Forty-nine out of 64 (77%) cases responded to 20 mcg of PGE1. Forty mcg of PGE1 was injected into the 15 non-responding cases, and 9 patients responded favorably. The overall effective rate was 58/64 (91 %). No major adverse effects were observed. Copyright

KW - Erectile dysfunction

KW - Intracavernous injection

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KW - Prostaglandin E

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Intracavernous injection of prostaglandin E₁ is effective in patients with erectile dysfunction not responding to phosphodiseterase 5 inhibitors

Abstract

Keywords

ASJC Scopus subject areas

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