Intracavernous injection of prostaglandin E1 is effective in patients with erectile dysfunction not responding to phosphodiseterase 5 inhibitors

Atsushi Nagai, Norihiro Kusumi, Hiromu Tsuboi, Kazushi Ishii, Takashi Saika, Yasutomo Nasu, Hiromi Kumon

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

We report on 64 patients who did not achieve erections adequate for satisfactory sexual intercourse from among a total of 243 patients who were prescribed PDE5 inhibitors for erectile dysfunction (ED). Intracavernous injection (ICI) of PGE1 was performed in this non-responder group. An ICI of 20 or 40 mcg of PGE1 in 1 ml saline was performed and the responses evaluated. Forty-nine out of 64 (77%) cases responded to 20 mcg of PGE1. Forty mcg of PGE1 was injected into the 15 non-responding cases, and 9 patients responded favorably. The overall effective rate was 58/64 (91 %). No major adverse effects were observed. Copyright

Original languageEnglish
Pages (from-to)279-280
Number of pages2
JournalActa medica Okayama
Volume59
Issue number6
Publication statusPublished - Dec 2005

Keywords

  • Erectile dysfunction
  • Intracavernous injection
  • PDE5 inhibitors
  • Prostaglandin E

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

Fingerprint Dive into the research topics of 'Intracavernous injection of prostaglandin E<sub>1</sub> is effective in patients with erectile dysfunction not responding to phosphodiseterase 5 inhibitors'. Together they form a unique fingerprint.

  • Cite this