Intracavernous injection of prostaglandin E1 is effective in patients with erectile dysfunction not responding to phosphodiseterase 5 inhibitors

Atsushi Nagai, Norihiro Kusumi, Hiromu Tsuboi, Kazushi Ishii, Takashi Saika, Yasutomo Nasu, Hiromi Kumon

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    8 Citations (Scopus)

    Abstract

    We report on 64 patients who did not achieve erections adequate for satisfactory sexual intercourse from among a total of 243 patients who were prescribed PDE5 inhibitors for erectile dysfunction (ED). Intracavernous injection (ICI) of PGE1 was performed in this non-responder group. An ICI of 20 or 40 mcg of PGE1 in 1 ml saline was performed and the responses evaluated. Forty-nine out of 64 (77%) cases responded to 20 mcg of PGE1. Forty mcg of PGE1 was injected into the 15 non-responding cases, and 9 patients responded favorably. The overall effective rate was 58/64 (91 %). No major adverse effects were observed. Copyright

    Original languageEnglish
    Pages (from-to)279-280
    Number of pages2
    JournalActa medica Okayama
    Volume59
    Issue number6
    Publication statusPublished - Dec 2005

    Keywords

    • Erectile dysfunction
    • Intracavernous injection
    • PDE5 inhibitors
    • Prostaglandin E

    ASJC Scopus subject areas

    • Biochemistry, Genetics and Molecular Biology(all)

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