Intraarterial Injection Chemotherapy Using Water-in-Oil (W/O) State Cisplatin-Lipiodol Emulsion (CPLEM) for Hepatocellular Carcinoma

Kazuo Mori, Fusako Takayama, Masaharu Takeyama, Michio Kobayashi

Research output: Contribution to journalArticle

Abstract

For the treatment of hepatocellular carcinoma by intra-hepatic arterial injection, CDDP-Lipiodol emulsion (CPLEM) was prepared. CPLEM was in a water-in-oil state, and showed moderate retaining and releasing of CDDP. Clinically, 9 patients with advanced hepatocellular carcinoma underwent the transarterial chemo-embolization by CPLEM. Partial response was observed in 2 cases, and minor response 1 case. AFP decreased considerably, and side effects were slight. Serum platinum concentrations after administration were low. Deconvolution of the present data was demonstrated, and leakage of CDDP from liver was supposed to be gradual. In conclusion, CPLEM was considered to be useful for mild chemo-embolization in a treatment of hepatocellular carcinoma.

Original languageEnglish
Pages (from-to)643-647
Number of pages5
JournalRinsho yakuri/Japanese Journal of Clinical Pharmacology and Therapeutics
Volume21
Issue number3
DOIs
Publication statusPublished - 1990
Externally publishedYes

Keywords

  • cisplatin
  • emulsion hepatocellular carcinoma
  • lipiodol

ASJC Scopus subject areas

  • Pharmacology
  • Pharmacology (medical)

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