Intraarterial Injection Chemotherapy Using Water-in-Oil (W/O) State Cisplatin-Lipiodol Emulsion (CPLEM) for Hepatocellular Carcinoma

Kazuo Mori; Fusako Takayama; Masaharu Takeyama; Michio Kobayashi

doi:10.3999/jscpt.21.643

Intraarterial Injection Chemotherapy Using Water-in-Oil (W/O) State Cisplatin-Lipiodol Emulsion (CPLEM) for Hepatocellular Carcinoma

Kazuo Mori, Fusako Takayama, Masaharu Takeyama, Michio Kobayashi

Research output: Contribution to journal › Article

Abstract

For the treatment of hepatocellular carcinoma by intra-hepatic arterial injection, CDDP-Lipiodol emulsion (CPLEM) was prepared. CPLEM was in a water-in-oil state, and showed moderate retaining and releasing of CDDP. Clinically, 9 patients with advanced hepatocellular carcinoma underwent the transarterial chemo-embolization by CPLEM. Partial response was observed in 2 cases, and minor response 1 case. AFP decreased considerably, and side effects were slight. Serum platinum concentrations after administration were low. Deconvolution of the present data was demonstrated, and leakage of CDDP from liver was supposed to be gradual. In conclusion, CPLEM was considered to be useful for mild chemo-embolization in a treatment of hepatocellular carcinoma.

Original language	English
Pages (from-to)	643-647
Number of pages	5
Journal	Rinsho yakuri/Japanese Journal of Clinical Pharmacology and Therapeutics
Volume	21
Issue number	3
DOIs	https://doi.org/10.3999/jscpt.21.643
Publication status	Published - 1990
Externally published	Yes

Keywords

cisplatin
emulsion hepatocellular carcinoma
lipiodol

ASJC Scopus subject areas

Pharmacology
Pharmacology (medical)

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Mori, K., Takayama, F., Takeyama, M., & Kobayashi, M. (1990). Intraarterial Injection Chemotherapy Using Water-in-Oil (W/O) State Cisplatin-Lipiodol Emulsion (CPLEM) for Hepatocellular Carcinoma. Rinsho yakuri/Japanese Journal of Clinical Pharmacology and Therapeutics, 21(3), 643-647. https://doi.org/10.3999/jscpt.21.643

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abstract = "For the treatment of hepatocellular carcinoma by intra-hepatic arterial injection, CDDP-Lipiodol emulsion (CPLEM) was prepared. CPLEM was in a water-in-oil state, and showed moderate retaining and releasing of CDDP. Clinically, 9 patients with advanced hepatocellular carcinoma underwent the transarterial chemo-embolization by CPLEM. Partial response was observed in 2 cases, and minor response 1 case. AFP decreased considerably, and side effects were slight. Serum platinum concentrations after administration were low. Deconvolution of the present data was demonstrated, and leakage of CDDP from liver was supposed to be gradual. In conclusion, CPLEM was considered to be useful for mild chemo-embolization in a treatment of hepatocellular carcinoma.",

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AU - Takeyama, Masaharu

AU - Kobayashi, Michio

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