Intra-arterial infusion chemotherapy for invasive bladder cancer

Tomoyasu Tsushima, Masatake Takamatsu, Shin Ebara, Shunko Kaku, Takanori Murakami, Yoshiyuki Miyaji, Yasuo Yamamoto, Yasutomo Nasu, Hiromi Kumon, Hiroyuki Ohmori, Satoshi Uno, Ryouji Arata, Kenji Aramaki, Taiichiro Johsen, Michinao Saegusa, Takafumi Akagi, Yujiro Ozaki, Kohji Shidahara, Yasuki Nakayama, Teruaki Akaeda

Research output: Contribution to journalArticle

Abstract

A total of 57 patients with invasive bladder cancer (T2 4, N0, M0) was treated with arterial infusion chemotherapy and their treatment outcome was evaluated. Each patient was given 70 mg/m2 of CDDP and 40 mg/m2 of ADM. During the treatment, 2 μg/min of angiotensin II were also administrated. Of 56 evaluable patients, CR was obtained in 9 patients, PR in 32, NC in 14 and PD in 1, providing an overall response rate of 73%. Following arterial infusion chemotherapy, total cystectomy was performed in 24 patients while bladder sparing therapy was performed in 32 patients. The follow up duration ranged from 3 to 128 months (median 34 months, average 41 months). The cause specific 5 year survival rate was 54% and the median survival duration was 61 months. Among patients treated with the bladder sparing approach, the cause specific 5 year survival rate was 65% and the event free 5 year survival rate was 26%, with the median event free duration being 29 months. The pathological T stage was lower than the clinical T stage in 12 out of 24 patients treated with total cystectomy, while the cause specific 5 year survival rate was 43%. Although the clinical response to this arterial infusion chemotherapy was encouraging, a bladder sparing approach based on this therapy was of only limited success. It remains unclear whether or not arterial infusion chemotherapy can improve prognosis for total cystectomy patients.

Original languageEnglish
Pages (from-to)263-267
Number of pages5
JournalNishinihon Journal of Urology
Volume59
Issue number4
Publication statusPublished - Apr 1 1997

Keywords

  • ADM
  • CDDP
  • angiotensin II
  • intra arterial infusion chemotherapy
  • invasive bladder cancer

ASJC Scopus subject areas

  • Urology

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  • Cite this

    Tsushima, T., Takamatsu, M., Ebara, S., Kaku, S., Murakami, T., Miyaji, Y., Yamamoto, Y., Nasu, Y., Kumon, H., Ohmori, H., Uno, S., Arata, R., Aramaki, K., Johsen, T., Saegusa, M., Akagi, T., Ozaki, Y., Shidahara, K., Nakayama, Y., & Akaeda, T. (1997). Intra-arterial infusion chemotherapy for invasive bladder cancer. Nishinihon Journal of Urology, 59(4), 263-267.