Nano-sized materials have received much attention lately, both in terms of their multiple applications and their biocompatibility. From both viewpoints, understanding the biodistribution of administered nano-materials is very important. In this study, we succeeded in visualizing the biodistribution of administered nano-materials using a scanning X-ray analytical microscope and magnetic resonance imaging method. Quantitative observation was carried out by inductively coupled plasma - atomic emission spectroscopy. We observed that the administered nano-particles accumulated in the liver, lung and spleen of mice. To estimate their cytocompatibility, the nano-particles were exposed to human liver cells. The results suggested that the micro-/ nano- particles have good cytocompatibility, except for copper oxide nano-particles.
|Journal||IOP Conference Series: Materials Science and Engineering|
|Issue number||SYMPOSIUM 13|
|Publication status||Published - 2011|
|Event||3rd International Congress on Ceramics, ICC3 - Osaka, Japan|
Duration: Nov 14 2010 → Nov 18 2010
ASJC Scopus subject areas
- Materials Science(all)