Internal distribution of micro- / Nano-sized inorganic particles and their cytocompatibility

Shigeaki Abe, Nobuki Iwadera, Mitsue Esaki, Ikuhiro Kida, Mami Mutoh, Tsukasa Akasaka, Motohiro Uo, Yasutaka Yawaka, Manabu Morita, Koichi Haneda, Tetsu Yonezawa, Fumio Watari

Research output: Chapter in Book/Report/Conference proceedingConference contribution

9 Citations (Scopus)

Abstract

Nano-sized materials have received much attention lately, both in terms of their multiple applications and their biocompatibility. From both viewpoints, understanding the biodistribution of administered nano-materials is very important. In this study, we succeeded in visualizing the biodistribution of administered nano-materials using a scanning X-ray analytical microscope and magnetic resonance imaging method. Quantitative observation was carried out by inductively coupled plasma - atomic emission spectroscopy. We observed that the administered nano-particles accumulated in the liver, lung and spleen of mice. To estimate their cytocompatibility, the nano-particles were exposed to human liver cells. The results suggested that the micro-/ nano- particles have good cytocompatibility, except for copper oxide nano-particles.

Original languageEnglish
Title of host publicationIOP Conference Series: Materials Science and Engineering
Volume18
EditionSYMPOSIUM 13
DOIs
Publication statusPublished - 2011
Event3rd International Congress on Ceramics, ICC3 - Osaka, Japan
Duration: Nov 14 2010Nov 18 2010

Other

Other3rd International Congress on Ceramics, ICC3
CountryJapan
CityOsaka
Period11/14/1011/18/10

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ASJC Scopus subject areas

  • Materials Science(all)
  • Engineering(all)

Cite this

Abe, S., Iwadera, N., Esaki, M., Kida, I., Mutoh, M., Akasaka, T., Uo, M., Yawaka, Y., Morita, M., Haneda, K., Yonezawa, T., & Watari, F. (2011). Internal distribution of micro- / Nano-sized inorganic particles and their cytocompatibility. In IOP Conference Series: Materials Science and Engineering (SYMPOSIUM 13 ed., Vol. 18). [192013] https://doi.org/10.1088/1757-899X/18/19/192013