Interleukin 13-positive mast cells are increased in immunoglobulin G4-related sialadenitis

Mai Takeuchi, Kyotaro Ohno, Katsuyoshi Takata, Yuka Gion, Tomoyasu Tachibana, Yorihisa Orita, Tadashi Yoshino, Yasuharu Sato

Research output: Contribution to journalArticle

15 Citations (Scopus)

Abstract

Interleukin (IL)-13 is a T helper 2 (Th2) cytokine that plays important roles in the pathogenesis of asthma. IL-13 induces hypersensitivity of the airways, increased mucous production, elevated serum immunoglobulin (Ig) E levels, and increased numbers of eosinophils. Many patients with IgG4-related disease have allergic backgrounds and show elevated serum IgE levels and an increase in the number of eosinophils. Upregulation of Th2/regulatory T (Treg) cytokines, including IL-13, has been detected in affected tissues of patients with IgG4-related disease. We previously reported that mast cells might be responsible for the production of the Th2/Treg cytokines IL-4, IL-10, and transforming growth factor (TGF)-β1 in IgG4-related disease. In this study, immunohistochemical analysis showed increased numbers of IL-13-positive mast cells in IgG4-related disease, which suggests that mast cells also produce IL-13 and contribute to elevation of serum IgE levels and eosinophil infiltration in IgG4-related disease.

Original languageEnglish
Article number7696
JournalScientific Reports
Volume5
DOIs
Publication statusPublished - Jan 9 2015

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Sialadenitis
Interleukin-13
Mast Cells
Immunoglobulins
Immunoglobulin G
Eosinophils
Immunoglobulin E
Cytokines
Serum
Transforming Growth Factors
Interleukin-4
Interleukin-10
Hypersensitivity
Up-Regulation
Asthma

ASJC Scopus subject areas

  • General

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Interleukin 13-positive mast cells are increased in immunoglobulin G4-related sialadenitis. / Takeuchi, Mai; Ohno, Kyotaro; Takata, Katsuyoshi; Gion, Yuka; Tachibana, Tomoyasu; Orita, Yorihisa; Yoshino, Tadashi; Sato, Yasuharu.

In: Scientific Reports, Vol. 5, 7696, 09.01.2015.

Research output: Contribution to journalArticle

Takeuchi, Mai ; Ohno, Kyotaro ; Takata, Katsuyoshi ; Gion, Yuka ; Tachibana, Tomoyasu ; Orita, Yorihisa ; Yoshino, Tadashi ; Sato, Yasuharu. / Interleukin 13-positive mast cells are increased in immunoglobulin G4-related sialadenitis. In: Scientific Reports. 2015 ; Vol. 5.
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AU - Yoshino, Tadashi

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