Interkinetic nuclear migration generates and opposes ventricular-zone crowding: Insight into tissue mechanics

Takaki Miyata, Mayumi Okamoto, Tomoyasu Shinoda, Ayano Kawaguchi

Research output: Contribution to journalReview articlepeer-review

51 Citations (Scopus)

Abstract

The neuroepithelium (NE) or ventricular zone (VZ), from which multiple types of brain cells arise, is pseudostratified. In the NE/VZ, neural progenitor cells are elongated along the apicobasal axis, and their nuclei assume different apicobasal positions. These nuclei move in a cell cycle-dependent manner, i.e., apicalward during G2 phase and basalward during G1 phase, a process called interkinetic nuclear migration (INM). This review will summarize and discuss several topics: the nature of the INM exhibited by neural progenitor cells, the mechanical difficulties associated with INM in the developing cerebral cortex, the community-level mechanisms underlying collective and efficient INM, the impact on overall brain formation when NE/VZ is overcrowded due to loss of INM, and whether and how neural progenitor INM varies among mammalian species. These discussions will be based on recent findings obtained in live, three-dimensional specimens using quantitative and mechanical approaches. Experiments in which overcrowding was induced in mouse neocortical NE/VZ, as well as comparisons of neocortical INM between mice and ferrets, have revealed that the behavior of NE/VZ cells can be affected by cellular densification. A consideration of the physical aspects in the NE/VZ and the mechanical difficulties associated with high-degree pseudostratification (PS) is important for achieving a better understanding of neocortical development and evolution.

Original languageEnglish
Article number473
JournalFrontiers in Cellular Neuroscience
Volume8
Issue numberJAN
DOIs
Publication statusPublished - Jan 28 2015
Externally publishedYes

Keywords

  • Cell division
  • Cortical development
  • Crowding
  • Interkinetic nuclear migration
  • Mechanical processes
  • Neural progenitor cells
  • Slice culture
  • Time-lapse imaging

ASJC Scopus subject areas

  • Cellular and Molecular Neuroscience

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