Interhemispheric connection of motor areas in humans

Kiyohito Terada, Naotaka Usui, Shuichi Umeoka, Koichi Baba, Tadahiro Mihara, Kazumi Matsuda, Takayasu Tottori, Takashi Agari, Fumihiro Nakamura, Yushi Inoue

Research output: Contribution to journalArticle

24 Citations (Scopus)

Abstract

We attempted to clarify functional interhemispheric connections of motor cortex (MC) by investigating cortico-cortical evoked potentials from human brains in vivo. Three patients with intractable epilepsy who underwent invasive EEG monitoring with subdural electrodes as presurgical evaluation were studied. Electric pulse stimuli were delivered in a bipolar fashion to two adjacent electrodes on and around MC. Cortico-cortical evoked potentials were recorded by averaging electrocorticograms from the contralateral hemisphere. An initial positive triphasic or an initial negative biphasic wave was recorded when the contralateral MCs were stimulated. When the non-MC electrodes were stimulated, no response was recorded. The latencies ranged from 9.2 to 23.8 ms for the initial positive peak, and 25.4 to 39.4 ms for the initial or the second negative peak. The cortico-cortical evoked potentials responses were maximal around the homonymous electrodes with the stimulated electrodes. Our results directly demonstrate the presence of the functional interhemispheric connections originating in MC. The interhemispheric transit time is indicated. The homotopic distribution of the responses indicates that motor coordination of the bilateral bodies is, at least partially, controlled within MC.

Original languageEnglish
Pages (from-to)351-356
Number of pages6
JournalJournal of Clinical Neurophysiology
Volume25
Issue number6
DOIs
Publication statusPublished - Dec 2008

Fingerprint

Motor Cortex
Electrodes
Evoked Potentials
Electroencephalography
Brain

Keywords

  • Corpus callosum
  • Evoked potential
  • Human brain
  • Motor cortex
  • Neural networks
  • Transcallosal connection

ASJC Scopus subject areas

  • Clinical Neurology
  • Neurology
  • Physiology
  • Physiology (medical)
  • Medicine(all)

Cite this

Terada, K., Usui, N., Umeoka, S., Baba, K., Mihara, T., Matsuda, K., ... Inoue, Y. (2008). Interhemispheric connection of motor areas in humans. Journal of Clinical Neurophysiology, 25(6), 351-356. https://doi.org/10.1097/WNP.0b013e31818f4fec

Interhemispheric connection of motor areas in humans. / Terada, Kiyohito; Usui, Naotaka; Umeoka, Shuichi; Baba, Koichi; Mihara, Tadahiro; Matsuda, Kazumi; Tottori, Takayasu; Agari, Takashi; Nakamura, Fumihiro; Inoue, Yushi.

In: Journal of Clinical Neurophysiology, Vol. 25, No. 6, 12.2008, p. 351-356.

Research output: Contribution to journalArticle

Terada, K, Usui, N, Umeoka, S, Baba, K, Mihara, T, Matsuda, K, Tottori, T, Agari, T, Nakamura, F & Inoue, Y 2008, 'Interhemispheric connection of motor areas in humans', Journal of Clinical Neurophysiology, vol. 25, no. 6, pp. 351-356. https://doi.org/10.1097/WNP.0b013e31818f4fec
Terada K, Usui N, Umeoka S, Baba K, Mihara T, Matsuda K et al. Interhemispheric connection of motor areas in humans. Journal of Clinical Neurophysiology. 2008 Dec;25(6):351-356. https://doi.org/10.1097/WNP.0b013e31818f4fec
Terada, Kiyohito ; Usui, Naotaka ; Umeoka, Shuichi ; Baba, Koichi ; Mihara, Tadahiro ; Matsuda, Kazumi ; Tottori, Takayasu ; Agari, Takashi ; Nakamura, Fumihiro ; Inoue, Yushi. / Interhemispheric connection of motor areas in humans. In: Journal of Clinical Neurophysiology. 2008 ; Vol. 25, No. 6. pp. 351-356.
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