Interfractional seminal vesicle motion relative to the prostate gland for image-guided radiotherapy for prostate cancer with/without androgen deprivation therapy: A retrospective cohort study

Takahiro Waki, Kuniaki Katsui, Toshiharu Mitsuhashi, Takeshi Ogata, Norihisa Katayama, Mitsuhiro Takemoto, Yasutomo Nasu, Hiromi Kumon, Susumu Kanazawa

Research output: Contribution to journalArticle

Abstract

We investigated differences in seminal vesicle (SV) length and interfractional SV motion relative to the prostate gland in prostate cancer patients. We compared 32 patients who received androgen deprivation therapy (ADT) before radiotherapy with 12 patients receiving radiotherapy alone at Okayama University Hospital in August 2008-July 2011. We examined the right and left SVs' length and motion by computed tomography (CT) to determine the ADT's effects and analyzed 347 CT scans in a multiple linear regression model. The ADT patients' SV length was significantly shorter than the non-ADT patients'. The differences in right and left SV lengths between the ADT and non-ADT patients were 6.8 mm (95% CI 2.0-11.7 mm) and 7.2 mm (95% CI 3.1- 11.3 mm) respectively in an adjusted regression model. SV motion did not differ between the ADT and non- ADT patients in terms of interfractional motion of the SV tips and the SVs' center relative to the prostate gland. The ADT patients had significantly shorter SVs compared to the non-ADT patients, but no difference in SV motion was observed. SV interfractional motion should thus be compensated using the same planning margins, regardless of whether ADT is used.

Original languageEnglish
Pages (from-to)31-39
Number of pages9
JournalActa Medica Okayama
Volume71
Issue number1
Publication statusPublished - 2017

Fingerprint

Image-Guided Radiotherapy
Seminal Vesicles
Radiotherapy
Androgens
Prostate
Prostatic Neoplasms
Cohort Studies
Retrospective Studies
Therapeutics
Tomography
Linear Models
Linear regression
Planning

Keywords

  • Androgen deprivation therapy
  • Imageguided radiotherapy
  • Prostate cancer
  • Seminal vesicle length
  • Seminal vesicle motion

ASJC Scopus subject areas

  • Medicine(all)
  • Biochemistry, Genetics and Molecular Biology(all)

Cite this

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title = "Interfractional seminal vesicle motion relative to the prostate gland for image-guided radiotherapy for prostate cancer with/without androgen deprivation therapy: A retrospective cohort study",
abstract = "We investigated differences in seminal vesicle (SV) length and interfractional SV motion relative to the prostate gland in prostate cancer patients. We compared 32 patients who received androgen deprivation therapy (ADT) before radiotherapy with 12 patients receiving radiotherapy alone at Okayama University Hospital in August 2008-July 2011. We examined the right and left SVs' length and motion by computed tomography (CT) to determine the ADT's effects and analyzed 347 CT scans in a multiple linear regression model. The ADT patients' SV length was significantly shorter than the non-ADT patients'. The differences in right and left SV lengths between the ADT and non-ADT patients were 6.8 mm (95{\%} CI 2.0-11.7 mm) and 7.2 mm (95{\%} CI 3.1- 11.3 mm) respectively in an adjusted regression model. SV motion did not differ between the ADT and non- ADT patients in terms of interfractional motion of the SV tips and the SVs' center relative to the prostate gland. The ADT patients had significantly shorter SVs compared to the non-ADT patients, but no difference in SV motion was observed. SV interfractional motion should thus be compensated using the same planning margins, regardless of whether ADT is used.",
keywords = "Androgen deprivation therapy, Imageguided radiotherapy, Prostate cancer, Seminal vesicle length, Seminal vesicle motion",
author = "Takahiro Waki and Kuniaki Katsui and Toshiharu Mitsuhashi and Takeshi Ogata and Norihisa Katayama and Mitsuhiro Takemoto and Yasutomo Nasu and Hiromi Kumon and Susumu Kanazawa",
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T1 - Interfractional seminal vesicle motion relative to the prostate gland for image-guided radiotherapy for prostate cancer with/without androgen deprivation therapy

T2 - A retrospective cohort study

AU - Waki, Takahiro

AU - Katsui, Kuniaki

AU - Mitsuhashi, Toshiharu

AU - Ogata, Takeshi

AU - Katayama, Norihisa

AU - Takemoto, Mitsuhiro

AU - Nasu, Yasutomo

AU - Kumon, Hiromi

AU - Kanazawa, Susumu

PY - 2017

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N2 - We investigated differences in seminal vesicle (SV) length and interfractional SV motion relative to the prostate gland in prostate cancer patients. We compared 32 patients who received androgen deprivation therapy (ADT) before radiotherapy with 12 patients receiving radiotherapy alone at Okayama University Hospital in August 2008-July 2011. We examined the right and left SVs' length and motion by computed tomography (CT) to determine the ADT's effects and analyzed 347 CT scans in a multiple linear regression model. The ADT patients' SV length was significantly shorter than the non-ADT patients'. The differences in right and left SV lengths between the ADT and non-ADT patients were 6.8 mm (95% CI 2.0-11.7 mm) and 7.2 mm (95% CI 3.1- 11.3 mm) respectively in an adjusted regression model. SV motion did not differ between the ADT and non- ADT patients in terms of interfractional motion of the SV tips and the SVs' center relative to the prostate gland. The ADT patients had significantly shorter SVs compared to the non-ADT patients, but no difference in SV motion was observed. SV interfractional motion should thus be compensated using the same planning margins, regardless of whether ADT is used.

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