Interferon-α2B, 5-fluorouracil and mitomycin C combination chemotherapy for metastatic renal cell carcinoma

T. Tsushima, M. Noda, Yasutomo Nasu, H. Ohmori, A. Yamamoto, H. Takigawa, S. Kagawa, Y. Matsumura, T. Matsumoto, I. Ogawa, A. Kawano, M. Nishi, S. Akazawa, S. Nakamura, K. Y. Akiyama, K. Tatara, Y. Sumiyoshi, Y. Aga, T. Yokota

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Abstract

A total of 24 patients with metastatic renal cell carcinoma were treated by recombinant interferon-α2b (IFN-α2b) in combination with 5-fluorouracil (5-FU) and mitomycin C (MMC). Combined treatment included IFN-α2b at 6 x 106 units per body, per day, administered intramuscularly, 5-FU at 500 mg/m2 per day, administered intravenously (days 1 to 5) and MMC 2 mg/m2 per day, administered intravenously (days 1 and 2), repeated every 28 days. Of the 22 evaluable patients, one showed CR and two showed PR, with a response rate of 13.6%. The response durations were 6, 7, and 40+ months. The median survival duration of eligible patients was 14.5 months (range 2 to 41+ months). The most frequent adverse reactions were gastrointestinal symptoms (83.3%), fatigue (70.8%), flu-like symptoms (62.5%) and bone marrow suppression (83.3%).

Original languageEnglish
Pages (from-to)986-991
Number of pages6
JournalNishinihon Journal of Urology
Volume56
Issue number9
Publication statusPublished - 1994

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Keywords

  • 5-fluorouracil
  • interferon-α
  • mitomycin C
  • renal cell carcinoma

ASJC Scopus subject areas

  • Urology

Cite this

Tsushima, T., Noda, M., Nasu, Y., Ohmori, H., Yamamoto, A., Takigawa, H., Kagawa, S., Matsumura, Y., Matsumoto, T., Ogawa, I., Kawano, A., Nishi, M., Akazawa, S., Nakamura, S., Akiyama, K. Y., Tatara, K., Sumiyoshi, Y., Aga, Y., & Yokota, T. (1994). Interferon-α2B, 5-fluorouracil and mitomycin C combination chemotherapy for metastatic renal cell carcinoma. Nishinihon Journal of Urology, 56(9), 986-991.