Integrated Synthesis of Thienyl Thioethers and Thieno[3,2-b]thiophenes via 1-Benzothiophen-3(2 H)-ones

Koichi Mitsudo, Nanae Habara, Yoshiaki Kobashi, Yuji Kurimoto, Hiroki Mandai, Seiji Suga

Research output: Contribution to journalArticlepeer-review

Abstract

A one-pot procedure for the synthesis of thienyl thioethers is described. Several thienyl thioethers were synthesized by a TfOH-promoted Friedel-Crafts-type cyclization, a subsequent nucleophilic attack by an arenethiol, and dehydration. This protocol was successfully applied to the synthesis of thienoacene derivatives by using a Pd-catalyzed dehydrogenative cyclization.

Original languageEnglish
Pages (from-to)1947-1952
Number of pages6
JournalSynlett
Volume31
Issue number19
DOIs
Publication statusPublished - Dec 1 2020

Keywords

  • halide-free
  • metal-free
  • one-pot synthesis
  • thienoacenes
  • thienyl thioethers
  • thioetherification

ASJC Scopus subject areas

  • Organic Chemistry

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