Insulin resistance-induced hypertension and a role of perivascular CGRPergic nerves

Shingo Takatori, Yoshito Zamami, Narumi Hashikawa-Hobara, Hiromu Kawasaki

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

Insulin resistance is defined as a preliminary step of type 2 diabetes mellitus with decreased insulin action evoked by continuous postprandial hyperglycemia, which is provoked by high fat and calories dieting, a lack of physical activity and obesity. In the early phase of type 2 diabetes mellitus, patients have a hyperinsulinemia to compensate deficient insulin action by increased secretion from the pancreas to maintain euglycemia. Then, pancreatic β cells progressively decrease secretion function, resulting in the development of diabetes mellitus with decreased serum insulin levels. Accumulating evidences show that insulin resistance is associated with hypertension. However, the mechanisms underlying hypertension associated with type 2 diabetes mellitus have still unknown. Therefore, to elucidate the mechanisms of insulin resistance-induced hypertension, we investigated that the effects of hyperinsulinemia or hyperglycemia on vascular responses mediated by perivascular nerves including sympathetic adrenergic nerves and calcitonin gene-related peptide (CGRP)-containing nerves (CGRPergic nerves). In this article, we show evidence that insulin resistance-induced hypertension could be resulted from increased density and function of sympathetic nerve, and decreased density and function of CGRPergic nerves. Furthermore, our findings provide a new insight into the research of therapeutic drugs for insulin resistance- induced hypertension.

Original languageEnglish
Pages (from-to)275-281
Number of pages7
JournalCurrent Protein and Peptide Science
Volume14
Issue number4
DOIs
Publication statusPublished - 2013
Externally publishedYes

Keywords

  • Hyperglycemia
  • Hyperinsulinemia
  • Hypertension
  • Insulin resistance
  • Perivascular CGRPergic nerves
  • Perivascular sympathetic adrenergic nerves

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Cell Biology

Fingerprint Dive into the research topics of 'Insulin resistance-induced hypertension and a role of perivascular CGRPergic nerves'. Together they form a unique fingerprint.

  • Cite this