Insulin-like growth factor I (IGF-I) distribution in the tissue and extracellular compartment in different regions of rat brain

Fuminori Yamaguchi, Toshifumi Itano, Masayuki Mizobuchi, Osamu Miyamoto, Najma A. Jangua, Hideki Matsui, Masaaki Tokuda, Takashi Ohmoto, Kiyoshi Hosokawa, Osamu Hatase

Research output: Contribution to journalArticle

38 Citations (Scopus)

Abstract

The regional distribution of insulin-like growth favtor I (IGF-I) was examined in the tissue and extracellular compartment of rat brain. The tissue content of IGF-I was the highest in the pituitary gland, followed by the olfactory bulb, upper brainstem, cerebellum, striatum, hippocampus, lower brainstem, and cerebral cortex. The extracellular concentration was studied by intracerebral microdialysis technique, and the highest content was found in the hippocampus, followed by the olfactory bulb, hypothalamus, cerebellum, striatum, and cerebral cortex. The tissue and extracellular contents were significantly correlated in the olfactory bulb, hypothalamus, cerebellum, striatum, and cerebral cortex. IGF-I might act by paracrine and/or autocrine regulatory mechanisms in these regions.

Original languageEnglish
Pages (from-to)344-347
Number of pages4
JournalBrain Research
Volume533
Issue number2
DOIs
Publication statusPublished - Nov 19 1990

Keywords

  • Autocrine
  • Distribution
  • Insulin-like growth factor I
  • Intracerebral microdialysis
  • Paracrine
  • Rat brain

ASJC Scopus subject areas

  • Neuroscience(all)
  • Molecular Biology
  • Clinical Neurology
  • Developmental Biology

Fingerprint Dive into the research topics of 'Insulin-like growth factor I (IGF-I) distribution in the tissue and extracellular compartment in different regions of rat brain'. Together they form a unique fingerprint.

  • Cite this

    Yamaguchi, F., Itano, T., Mizobuchi, M., Miyamoto, O., Jangua, N. A., Matsui, H., Tokuda, M., Ohmoto, T., Hosokawa, K., & Hatase, O. (1990). Insulin-like growth factor I (IGF-I) distribution in the tissue and extracellular compartment in different regions of rat brain. Brain Research, 533(2), 344-347. https://doi.org/10.1016/0006-8993(90)91361-J