Abstract
Insulin-like growth factor-1 (IGF-1) was applied topically on the brain surface of reperfused rat brain after 60 min of transient middle cerebral artery (MCA) occlusion. In contrast to the cases treated with vehicle, the infarct volume was greatly reduced at 24 h of reperfusion by the treatment with IGF-1. Immunohistochemical analysis in the MCA territory showed that the increase of cyclin-dependent kinase 5 (cdk5) was greatly reduced, and that the decrease of the critical regulatory subunit of cdk5, p35, was preserved with treatment of IGF-1. The present results suggest that IGF-1 has a significant effect on ameliorating brain injury after transient focal brain ischemia with affecting the expressions of cdk5 and its activator p35. Copyright (C) 1999 Elsevier Science Ireland Ltd.
| Original language | English |
|---|---|
| Pages (from-to) | 17-20 |
| Number of pages | 4 |
| Journal | Neuroscience Letters |
| Volume | 277 |
| Issue number | 1 |
| DOIs | |
| Publication status | Published - Dec 17 1999 |
Fingerprint
Keywords
- Cerebral ischemia
- Cyclin-dependent kinase 5
- Cytoskeletal proteins
- Insulin-like growth factor-1
- Middle cerebral artery occlusion
- P35
- Rat
ASJC Scopus subject areas
- Neuroscience(all)
Cite this
Insulin-like growth factor-1 affects expressions of cyclin-dependent kinase 5 and its activator p35 in reperfused rat brain. / Wang, J. M.; Hayashi, T.; Zhang, W. R.; Sakai, K.; Shiro, Y.; Abe, Koji.
In: Neuroscience Letters, Vol. 277, No. 1, 17.12.1999, p. 17-20.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Insulin-like growth factor-1 affects expressions of cyclin-dependent kinase 5 and its activator p35 in reperfused rat brain
AU - Wang, J. M.
AU - Hayashi, T.
AU - Zhang, W. R.
AU - Sakai, K.
AU - Shiro, Y.
AU - Abe, Koji
PY - 1999/12/17
Y1 - 1999/12/17
N2 - Insulin-like growth factor-1 (IGF-1) was applied topically on the brain surface of reperfused rat brain after 60 min of transient middle cerebral artery (MCA) occlusion. In contrast to the cases treated with vehicle, the infarct volume was greatly reduced at 24 h of reperfusion by the treatment with IGF-1. Immunohistochemical analysis in the MCA territory showed that the increase of cyclin-dependent kinase 5 (cdk5) was greatly reduced, and that the decrease of the critical regulatory subunit of cdk5, p35, was preserved with treatment of IGF-1. The present results suggest that IGF-1 has a significant effect on ameliorating brain injury after transient focal brain ischemia with affecting the expressions of cdk5 and its activator p35. Copyright (C) 1999 Elsevier Science Ireland Ltd.
AB - Insulin-like growth factor-1 (IGF-1) was applied topically on the brain surface of reperfused rat brain after 60 min of transient middle cerebral artery (MCA) occlusion. In contrast to the cases treated with vehicle, the infarct volume was greatly reduced at 24 h of reperfusion by the treatment with IGF-1. Immunohistochemical analysis in the MCA territory showed that the increase of cyclin-dependent kinase 5 (cdk5) was greatly reduced, and that the decrease of the critical regulatory subunit of cdk5, p35, was preserved with treatment of IGF-1. The present results suggest that IGF-1 has a significant effect on ameliorating brain injury after transient focal brain ischemia with affecting the expressions of cdk5 and its activator p35. Copyright (C) 1999 Elsevier Science Ireland Ltd.
KW - Cerebral ischemia
KW - Cyclin-dependent kinase 5
KW - Cytoskeletal proteins
KW - Insulin-like growth factor-1
KW - Middle cerebral artery occlusion
KW - P35
KW - Rat
UR - http://www.scopus.com/inward/record.url?scp=0032750974&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0032750974&partnerID=8YFLogxK
U2 - 10.1016/S0304-3940(99)00829-0
DO - 10.1016/S0304-3940(99)00829-0
M3 - Article
C2 - 10643887
AN - SCOPUS:0032750974
VL - 277
SP - 17
EP - 20
JO - Neuroscience Letters
JF - Neuroscience Letters
SN - 0304-3940
IS - 1
ER -