Insulin-like growth factor-1 affects expressions of cyclin-dependent kinase 5 and its activator p35 in reperfused rat brain

J. M. Wang; T. Hayashi; W. R. Zhang; K. Sakai; Y. Shiro; K. Abe

doi:10.1016/S0304-3940(99)00829-0

Insulin-like growth factor-1 affects expressions of cyclin-dependent kinase 5 and its activator p35 in reperfused rat brain

J. M. Wang, T. Hayashi, W. R. Zhang, K. Sakai, Y. Shiro, K. Abe

Research output: Contribution to journal › Article › peer-review

3 Citations (Scopus)

Abstract

Insulin-like growth factor-1 (IGF-1) was applied topically on the brain surface of reperfused rat brain after 60 min of transient middle cerebral artery (MCA) occlusion. In contrast to the cases treated with vehicle, the infarct volume was greatly reduced at 24 h of reperfusion by the treatment with IGF-1. Immunohistochemical analysis in the MCA territory showed that the increase of cyclin-dependent kinase 5 (cdk5) was greatly reduced, and that the decrease of the critical regulatory subunit of cdk5, p35, was preserved with treatment of IGF-1. The present results suggest that IGF-1 has a significant effect on ameliorating brain injury after transient focal brain ischemia with affecting the expressions of cdk5 and its activator p35. Copyright (C) 1999 Elsevier Science Ireland Ltd.

Original language	English
Pages (from-to)	17-20
Number of pages	4
Journal	Neuroscience Letters
Volume	277
Issue number	1
DOIs	https://doi.org/10.1016/S0304-3940(99)00829-0
Publication status	Published - Dec 17 1999

Keywords

Cerebral ischemia
Cyclin-dependent kinase 5
Cytoskeletal proteins
Insulin-like growth factor-1
Middle cerebral artery occlusion
P35
Rat

ASJC Scopus subject areas

Neuroscience(all)

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title = "Insulin-like growth factor-1 affects expressions of cyclin-dependent kinase 5 and its activator p35 in reperfused rat brain",

abstract = "Insulin-like growth factor-1 (IGF-1) was applied topically on the brain surface of reperfused rat brain after 60 min of transient middle cerebral artery (MCA) occlusion. In contrast to the cases treated with vehicle, the infarct volume was greatly reduced at 24 h of reperfusion by the treatment with IGF-1. Immunohistochemical analysis in the MCA territory showed that the increase of cyclin-dependent kinase 5 (cdk5) was greatly reduced, and that the decrease of the critical regulatory subunit of cdk5, p35, was preserved with treatment of IGF-1. The present results suggest that IGF-1 has a significant effect on ameliorating brain injury after transient focal brain ischemia with affecting the expressions of cdk5 and its activator p35. Copyright (C) 1999 Elsevier Science Ireland Ltd.",

keywords = "Cerebral ischemia, Cyclin-dependent kinase 5, Cytoskeletal proteins, Insulin-like growth factor-1, Middle cerebral artery occlusion, P35, Rat",

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T1 - Insulin-like growth factor-1 affects expressions of cyclin-dependent kinase 5 and its activator p35 in reperfused rat brain

AU - Wang, J. M.

AU - Hayashi, T.

AU - Zhang, W. R.

AU - Sakai, K.

AU - Shiro, Y.

AU - Abe, K.

PY - 1999/12/17

Y1 - 1999/12/17

N2 - Insulin-like growth factor-1 (IGF-1) was applied topically on the brain surface of reperfused rat brain after 60 min of transient middle cerebral artery (MCA) occlusion. In contrast to the cases treated with vehicle, the infarct volume was greatly reduced at 24 h of reperfusion by the treatment with IGF-1. Immunohistochemical analysis in the MCA territory showed that the increase of cyclin-dependent kinase 5 (cdk5) was greatly reduced, and that the decrease of the critical regulatory subunit of cdk5, p35, was preserved with treatment of IGF-1. The present results suggest that IGF-1 has a significant effect on ameliorating brain injury after transient focal brain ischemia with affecting the expressions of cdk5 and its activator p35. Copyright (C) 1999 Elsevier Science Ireland Ltd.

AB - Insulin-like growth factor-1 (IGF-1) was applied topically on the brain surface of reperfused rat brain after 60 min of transient middle cerebral artery (MCA) occlusion. In contrast to the cases treated with vehicle, the infarct volume was greatly reduced at 24 h of reperfusion by the treatment with IGF-1. Immunohistochemical analysis in the MCA territory showed that the increase of cyclin-dependent kinase 5 (cdk5) was greatly reduced, and that the decrease of the critical regulatory subunit of cdk5, p35, was preserved with treatment of IGF-1. The present results suggest that IGF-1 has a significant effect on ameliorating brain injury after transient focal brain ischemia with affecting the expressions of cdk5 and its activator p35. Copyright (C) 1999 Elsevier Science Ireland Ltd.

KW - Cerebral ischemia

KW - Cyclin-dependent kinase 5

KW - Cytoskeletal proteins

KW - Insulin-like growth factor-1

KW - Middle cerebral artery occlusion

KW - P35

KW - Rat

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