Insulin administration suppresses an increase in insulin-like growth factor binding protein-2 gene expression stimulated by fasting in the chicken

K. Nagao, M. Aman Yaman, A. Murai, T. Sasaki, Noboru Saito, J. Okumura, K. Kita

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

1. We examined the changes in plasma IGF-I concentration and tissue IGFBP-2 gene expression of young fasted chickens refed a commercial diet or administered bovine insulin intravenously. 2. Plasma IGF-I concentration was decreased by fasting for 2 d. Although plasma IGF-I concentration was increased by refeeding, it didn't recover to the level of chickens fed a commercial diet ad libitum. 3. Insulin administration lowered plasma IGF-I concentration compared to other groups. 4. Hepatic IGFBP-2 mRNA was increased by fasting for 2 d and decreased by refeeding for 6 h. Insulin administration also decreased hepatic IGFBP-2 gene expression stimulated by fasting to the level of refed chickens. 5. IGFBP-2 mRNA in the gizzard was increased by fasting for 2 d and tended to decrease after refeeding for 6 h. Insulin administration decreased gizzard IGFBP-2 gene expression to less than that in refed chickens. 6. There was no between-treatment difference in IGFBP-2 mRNA in the brain and kidney. 7. These results suggest that the changes in IGFBP-2 gene expression in the liver and gizzard by fasting and refeeding might be partly regulated by the alteration in plasma insulin concentration.

Original languageEnglish
Pages (from-to)501-504
Number of pages4
JournalBritish Poultry Science
Volume42
Issue number4
DOIs
Publication statusPublished - 2001
Externally publishedYes

Fingerprint

Insulin-Like Growth Factor Binding Protein 2
insulin-like growth factor binding proteins
fasting
Chickens
Fasting
insulin
Insulin
chickens
Gene Expression
refeeding
gene expression
insulin-like growth factor I
Avian Gizzard
Insulin-Like Growth Factor I
gizzard
Messenger RNA
liver
Liver
Diet
diet

ASJC Scopus subject areas

  • Animal Science and Zoology

Cite this

Insulin administration suppresses an increase in insulin-like growth factor binding protein-2 gene expression stimulated by fasting in the chicken. / Nagao, K.; Aman Yaman, M.; Murai, A.; Sasaki, T.; Saito, Noboru; Okumura, J.; Kita, K.

In: British Poultry Science, Vol. 42, No. 4, 2001, p. 501-504.

Research output: Contribution to journalArticle

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AU - Okumura, J.

AU - Kita, K.

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