INSIG2 gene rs7566605 polymorphism is associated with severe obesity in Japanese

Kikuko Hotta; Michihiro Nakamura; Yoshio Nakata; Tomoaki Matsuo; Seika Kamohara; Kazuaki Kotani; Ryoya Komatsu; Naoto Itoh; Ikuo Mineo; Jun Wada; Hiroaki Masuzaki; Masato Yoneda; Atsushi Nakajima; Shigeru Miyazaki; Katsuto Tokunaga; Manabu Kawamoto; Tohru Funahashi; Kazuyuki Hamaguchi; Kentaro Yamada; Toshiaki Hanafusa; Shinichi Oikawa; Hironobu Yoshimatsu; Kazuwa Nakao; Toshiie Sakata; Yuji Matsuzawa; Kiyoji Tanaka; Naoyuki Kamatani; Yusuke Nakamura

doi:10.1007/s10038-008-0317-8

INSIG2 gene rs7566605 polymorphism is associated with severe obesity in Japanese

Kikuko Hotta, Michihiro Nakamura, Yoshio Nakata, Tomoaki Matsuo, Seika Kamohara, Kazuaki Kotani, Ryoya Komatsu, Naoto Itoh, Ikuo Mineo, Jun Wada, Hiroaki Masuzaki, Masato Yoneda, Atsushi Nakajima, Shigeru Miyazaki, Katsuto Tokunaga, Manabu Kawamoto, Tohru Funahashi, Kazuyuki Hamaguchi, Kentaro Yamada, Toshiaki HanafusaShinichi Oikawa, Hironobu Yoshimatsu, Kazuwa Nakao, Toshiie Sakata, Yuji Matsuzawa, Kiyoji Tanaka, Naoyuki Kamatani, Yusuke Nakamura

Research output: Contribution to journal › Article

34 Citations (Scopus)

Abstract

The single nucleotide polymorphism (SNP) rs7566605 in the upstream region of the insulin-induced gene 2 (INSIG2) is associated with the obesity phenotype in many Caucasian populations. In Japanese, this association with the obesity phenotype is not clear. To investigate the relationship between rs7566605 and obesity in Japanese, we genotyped rs7566605 from severely obese subjects [n = 908, body mass index (BMI) ≥ 30 kg/m²] and normal-weight control subjects (n = 1495, BMI < 25 kg/m²). A case-control association analysis revealed that rs7566605 was significantly associated with obesity in Japanese. The P value in the minor allele recessive mode was 0.00020, and the odds ratio (OR) adjusted for gender and age was 1.61 [95% confidential interval (CI) = 1.24-2.09]. Obesity-associated phenotypes, which included the level of BMI, plasma glucose, hemoglobin A1c, total cholesterol, triglycerides, high-density lipoprotein (HDL) cholesterol, and blood pressure, were not associated with the rs7566605 genotype. Thus, rs7566605 in the upstream region of the INSIG2 gene was found to be associated with obesity, i.e., severe obesity, in Japanese.

Original language	English
Pages (from-to)	857-862
Number of pages	6
Journal	Journal of Human Genetics
Volume	53
Issue number	9
DOIs	https://doi.org/10.1007/s10038-008-0317-8
Publication status	Published - Sep 2008

Keywords

Association
Insulin-induced gene 2
Japanese population
Obesity
SNP

ASJC Scopus subject areas

Genetics
Genetics(clinical)

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Hotta, K., Nakamura, M., Nakata, Y., Matsuo, T., Kamohara, S., Kotani, K., Komatsu, R., Itoh, N., Mineo, I., Wada, J., Masuzaki, H., Yoneda, M., Nakajima, A., Miyazaki, S., Tokunaga, K., Kawamoto, M., Funahashi, T., Hamaguchi, K., Yamada, K., ... Nakamura, Y. (2008). INSIG2 gene rs7566605 polymorphism is associated with severe obesity in Japanese. Journal of Human Genetics, 53(9), 857-862. https://doi.org/10.1007/s10038-008-0317-8

INSIG2 gene rs7566605 polymorphism is associated with severe obesity in Japanese. / Hotta, Kikuko; Nakamura, Michihiro; Nakata, Yoshio; Matsuo, Tomoaki; Kamohara, Seika; Kotani, Kazuaki; Komatsu, Ryoya; Itoh, Naoto; Mineo, Ikuo; Wada, Jun; Masuzaki, Hiroaki; Yoneda, Masato; Nakajima, Atsushi; Miyazaki, Shigeru; Tokunaga, Katsuto; Kawamoto, Manabu; Funahashi, Tohru; Hamaguchi, Kazuyuki; Yamada, Kentaro; Hanafusa, Toshiaki; Oikawa, Shinichi; Yoshimatsu, Hironobu; Nakao, Kazuwa; Sakata, Toshiie; Matsuzawa, Yuji; Tanaka, Kiyoji; Kamatani, Naoyuki; Nakamura, Yusuke.

In: Journal of Human Genetics, Vol. 53, No. 9, 09.2008, p. 857-862.

Research output: Contribution to journal › Article

Hotta, K, Nakamura, M, Nakata, Y, Matsuo, T, Kamohara, S, Kotani, K, Komatsu, R, Itoh, N, Mineo, I, Wada, J, Masuzaki, H, Yoneda, M, Nakajima, A, Miyazaki, S, Tokunaga, K, Kawamoto, M, Funahashi, T, Hamaguchi, K, Yamada, K, Hanafusa, T, Oikawa, S, Yoshimatsu, H, Nakao, K, Sakata, T, Matsuzawa, Y, Tanaka, K, Kamatani, N & Nakamura, Y 2008, 'INSIG2 gene rs7566605 polymorphism is associated with severe obesity in Japanese', Journal of Human Genetics, vol. 53, no. 9, pp. 857-862. https://doi.org/10.1007/s10038-008-0317-8

Hotta, Kikuko ; Nakamura, Michihiro ; Nakata, Yoshio ; Matsuo, Tomoaki ; Kamohara, Seika ; Kotani, Kazuaki ; Komatsu, Ryoya ; Itoh, Naoto ; Mineo, Ikuo ; Wada, Jun ; Masuzaki, Hiroaki ; Yoneda, Masato ; Nakajima, Atsushi ; Miyazaki, Shigeru ; Tokunaga, Katsuto ; Kawamoto, Manabu ; Funahashi, Tohru ; Hamaguchi, Kazuyuki ; Yamada, Kentaro ; Hanafusa, Toshiaki ; Oikawa, Shinichi ; Yoshimatsu, Hironobu ; Nakao, Kazuwa ; Sakata, Toshiie ; Matsuzawa, Yuji ; Tanaka, Kiyoji ; Kamatani, Naoyuki ; Nakamura, Yusuke. / INSIG2 gene rs7566605 polymorphism is associated with severe obesity in Japanese. In: Journal of Human Genetics. 2008 ; Vol. 53, No. 9. pp. 857-862.

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abstract = "The single nucleotide polymorphism (SNP) rs7566605 in the upstream region of the insulin-induced gene 2 (INSIG2) is associated with the obesity phenotype in many Caucasian populations. In Japanese, this association with the obesity phenotype is not clear. To investigate the relationship between rs7566605 and obesity in Japanese, we genotyped rs7566605 from severely obese subjects [n = 908, body mass index (BMI) ≥ 30 kg/m2] and normal-weight control subjects (n = 1495, BMI < 25 kg/m2). A case-control association analysis revealed that rs7566605 was significantly associated with obesity in Japanese. The P value in the minor allele recessive mode was 0.00020, and the odds ratio (OR) adjusted for gender and age was 1.61 [95% confidential interval (CI) = 1.24-2.09]. Obesity-associated phenotypes, which included the level of BMI, plasma glucose, hemoglobin A1c, total cholesterol, triglycerides, high-density lipoprotein (HDL) cholesterol, and blood pressure, were not associated with the rs7566605 genotype. Thus, rs7566605 in the upstream region of the INSIG2 gene was found to be associated with obesity, i.e., severe obesity, in Japanese.",

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AU - Hotta, Kikuko

AU - Nakamura, Michihiro

AU - Nakata, Yoshio

AU - Matsuo, Tomoaki

AU - Kamohara, Seika

AU - Kotani, Kazuaki

AU - Komatsu, Ryoya

AU - Itoh, Naoto

AU - Mineo, Ikuo

AU - Wada, Jun

AU - Masuzaki, Hiroaki

AU - Yoneda, Masato

AU - Nakajima, Atsushi

AU - Miyazaki, Shigeru

AU - Tokunaga, Katsuto

AU - Kawamoto, Manabu

AU - Funahashi, Tohru

AU - Hamaguchi, Kazuyuki

AU - Yamada, Kentaro

AU - Hanafusa, Toshiaki

AU - Oikawa, Shinichi

AU - Yoshimatsu, Hironobu

AU - Nakao, Kazuwa

AU - Sakata, Toshiie

AU - Matsuzawa, Yuji

AU - Tanaka, Kiyoji

AU - Kamatani, Naoyuki

AU - Nakamura, Yusuke

PY - 2008/9

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N2 - The single nucleotide polymorphism (SNP) rs7566605 in the upstream region of the insulin-induced gene 2 (INSIG2) is associated with the obesity phenotype in many Caucasian populations. In Japanese, this association with the obesity phenotype is not clear. To investigate the relationship between rs7566605 and obesity in Japanese, we genotyped rs7566605 from severely obese subjects [n = 908, body mass index (BMI) ≥ 30 kg/m2] and normal-weight control subjects (n = 1495, BMI < 25 kg/m2). A case-control association analysis revealed that rs7566605 was significantly associated with obesity in Japanese. The P value in the minor allele recessive mode was 0.00020, and the odds ratio (OR) adjusted for gender and age was 1.61 [95% confidential interval (CI) = 1.24-2.09]. Obesity-associated phenotypes, which included the level of BMI, plasma glucose, hemoglobin A1c, total cholesterol, triglycerides, high-density lipoprotein (HDL) cholesterol, and blood pressure, were not associated with the rs7566605 genotype. Thus, rs7566605 in the upstream region of the INSIG2 gene was found to be associated with obesity, i.e., severe obesity, in Japanese.

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