Abstract
The single nucleotide polymorphism (SNP) rs7566605 in the upstream region of the insulin-induced gene 2 (INSIG2) is associated with the obesity phenotype in many Caucasian populations. In Japanese, this association with the obesity phenotype is not clear. To investigate the relationship between rs7566605 and obesity in Japanese, we genotyped rs7566605 from severely obese subjects [n = 908, body mass index (BMI) ≥ 30 kg/m2] and normal-weight control subjects (n = 1495, BMI <25 kg/m2). A case-control association analysis revealed that rs7566605 was significantly associated with obesity in Japanese. The P value in the minor allele recessive mode was 0.00020, and the odds ratio (OR) adjusted for gender and age was 1.61 [95% confidential interval (CI) = 1.24-2.09]. Obesity-associated phenotypes, which included the level of BMI, plasma glucose, hemoglobin A1c, total cholesterol, triglycerides, high-density lipoprotein (HDL) cholesterol, and blood pressure, were not associated with the rs7566605 genotype. Thus, rs7566605 in the upstream region of the INSIG2 gene was found to be associated with obesity, i.e., severe obesity, in Japanese.
| Original language | English |
|---|---|
| Pages (from-to) | 857-862 |
| Number of pages | 6 |
| Journal | Journal of Human Genetics |
| Volume | 53 |
| Issue number | 9 |
| DOIs | |
| Publication status | Published - Sep 2008 |
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Keywords
- Association
- Insulin-induced gene 2
- Japanese population
- Obesity
- SNP
ASJC Scopus subject areas
- Genetics(clinical)
- Genetics
Cite this
INSIG2 gene rs7566605 polymorphism is associated with severe obesity in Japanese. / Hotta, Kikuko; Nakamura, Michihiro; Nakata, Yoshio; Matsuo, Tomoaki; Kamohara, Seika; Kotani, Kazuaki; Komatsu, Ryoya; Itoh, Naoto; Mineo, Ikuo; Wada, Jun; Masuzaki, Hiroaki; Yoneda, Masato; Nakajima, Atsushi; Miyazaki, Shigeru; Tokunaga, Katsuto; Kawamoto, Manabu; Funahashi, Tohru; Hamaguchi, Kazuyuki; Yamada, Kentaro; Hanafusa, Toshiaki; Oikawa, Shinichi; Yoshimatsu, Hironobu; Nakao, Kazuwa; Sakata, Toshiie; Matsuzawa, Yuji; Tanaka, Kiyoji; Kamatani, Naoyuki; Nakamura, Yusuke.
In: Journal of Human Genetics, Vol. 53, No. 9, 09.2008, p. 857-862.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - INSIG2 gene rs7566605 polymorphism is associated with severe obesity in Japanese
AU - Hotta, Kikuko
AU - Nakamura, Michihiro
AU - Nakata, Yoshio
AU - Matsuo, Tomoaki
AU - Kamohara, Seika
AU - Kotani, Kazuaki
AU - Komatsu, Ryoya
AU - Itoh, Naoto
AU - Mineo, Ikuo
AU - Wada, Jun
AU - Masuzaki, Hiroaki
AU - Yoneda, Masato
AU - Nakajima, Atsushi
AU - Miyazaki, Shigeru
AU - Tokunaga, Katsuto
AU - Kawamoto, Manabu
AU - Funahashi, Tohru
AU - Hamaguchi, Kazuyuki
AU - Yamada, Kentaro
AU - Hanafusa, Toshiaki
AU - Oikawa, Shinichi
AU - Yoshimatsu, Hironobu
AU - Nakao, Kazuwa
AU - Sakata, Toshiie
AU - Matsuzawa, Yuji
AU - Tanaka, Kiyoji
AU - Kamatani, Naoyuki
AU - Nakamura, Yusuke
PY - 2008/9
Y1 - 2008/9
N2 - The single nucleotide polymorphism (SNP) rs7566605 in the upstream region of the insulin-induced gene 2 (INSIG2) is associated with the obesity phenotype in many Caucasian populations. In Japanese, this association with the obesity phenotype is not clear. To investigate the relationship between rs7566605 and obesity in Japanese, we genotyped rs7566605 from severely obese subjects [n = 908, body mass index (BMI) ≥ 30 kg/m2] and normal-weight control subjects (n = 1495, BMI <25 kg/m2). A case-control association analysis revealed that rs7566605 was significantly associated with obesity in Japanese. The P value in the minor allele recessive mode was 0.00020, and the odds ratio (OR) adjusted for gender and age was 1.61 [95% confidential interval (CI) = 1.24-2.09]. Obesity-associated phenotypes, which included the level of BMI, plasma glucose, hemoglobin A1c, total cholesterol, triglycerides, high-density lipoprotein (HDL) cholesterol, and blood pressure, were not associated with the rs7566605 genotype. Thus, rs7566605 in the upstream region of the INSIG2 gene was found to be associated with obesity, i.e., severe obesity, in Japanese.
AB - The single nucleotide polymorphism (SNP) rs7566605 in the upstream region of the insulin-induced gene 2 (INSIG2) is associated with the obesity phenotype in many Caucasian populations. In Japanese, this association with the obesity phenotype is not clear. To investigate the relationship between rs7566605 and obesity in Japanese, we genotyped rs7566605 from severely obese subjects [n = 908, body mass index (BMI) ≥ 30 kg/m2] and normal-weight control subjects (n = 1495, BMI <25 kg/m2). A case-control association analysis revealed that rs7566605 was significantly associated with obesity in Japanese. The P value in the minor allele recessive mode was 0.00020, and the odds ratio (OR) adjusted for gender and age was 1.61 [95% confidential interval (CI) = 1.24-2.09]. Obesity-associated phenotypes, which included the level of BMI, plasma glucose, hemoglobin A1c, total cholesterol, triglycerides, high-density lipoprotein (HDL) cholesterol, and blood pressure, were not associated with the rs7566605 genotype. Thus, rs7566605 in the upstream region of the INSIG2 gene was found to be associated with obesity, i.e., severe obesity, in Japanese.
KW - Association
KW - Insulin-induced gene 2
KW - Japanese population
KW - Obesity
KW - SNP
UR - http://www.scopus.com/inward/record.url?scp=50249187618&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=50249187618&partnerID=8YFLogxK
U2 - 10.1007/s10038-008-0317-8
DO - 10.1007/s10038-008-0317-8
M3 - Article
VL - 53
SP - 857
EP - 862
JO - Journal of Human Genetics
JF - Journal of Human Genetics
SN - 1434-5161
IS - 9
ER -