Innovation of vascular engineering by mechanomedicine

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

This article describes how physical forces contribute to development, physiology, and pathology of vascular cells, focusing on endothelial cells and vascular smooth muscle cells. Based on these basic understandings of the mechanobiology, we discuss mechanomedicine, an application of the mechanobiology to medicine. Basic knowledge about cellular responses, such as cellular signal transduction pathway, gene expression, and cytoskeletal remodeling, to mechanical stimuli is important for understanding the pathology of vascular diseases including atherosclerosis. Introducing the knowledge of the vascular mechanobiology will not only contribute to the development of regenerative medicine using pluripotent stem cells but also provide a way to prevent diseases caused by thromboembolisms, such as myocardial and cerebral infarctions.

Original languageEnglish
Title of host publicationVascular Engineering
Subtitle of host publicationNew Prospects of Vascular Medicine and Biology with a Multidiscipline Approach
PublisherSpringer Japan
Pages283-296
Number of pages14
ISBN (Electronic)9784431548010
ISBN (Print)9784431548003
DOIs
Publication statusPublished - Jan 1 2016

Keywords

  • Angiogenesis
  • Endothelial cell
  • Mechanical stimulus
  • Mechanobiology
  • Regenerative medicine
  • Vascular cell
  • Vascular smooth muscle cell

ASJC Scopus subject areas

  • Medicine(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Engineering(all)

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  • Cite this

    Takahashi, K., & Naruse, K. (2016). Innovation of vascular engineering by mechanomedicine. In Vascular Engineering: New Prospects of Vascular Medicine and Biology with a Multidiscipline Approach (pp. 283-296). Springer Japan. https://doi.org/10.1007/978-4-431-54801-0_15