TY - JOUR
T1 - Initiation of treatment and selection of antiepileptic drugs in childhood epilepsy
AU - Oka, Eiji
AU - Murakami, Nagako
AU - Ogino, Tatsuya
AU - Kobayashi, Katsuhiro
AU - Ohmori, Iori
AU - Akiyama, Tomoyuki
AU - Ito, Minako
PY - 2004
Y1 - 2004
N2 - Purpose: A retrospective study was carried out on 53 cases with childhood epilepsy to evaluate the validity of the initial selection of antiepileptic drug (AED). Methods: We investigated the AEDs selected at the beginning of the treatment from the medical records of 53 untreated cases. A follow-up study was undertaken to evaluate the effects of the AEDs. In the second study, we investigated the AEDs of 10 cases with atypical benign partial epilepsy (ABPE), to clarify whether the initial AEDs selected for rolandic epilepsy were related to the appearance of ABPE. Results: The AEDs used at the initial stage consisted of carbamazepine (CBZ), valproic acid (VPA), phenobarbital (PB), and vitamin B6. The main AEDs were CBZ and VPA for localization-related epilepsy, and VPA for generalized epilepsy. The initial selection of AEDs in 41 (85.4%) of 48 cases treated with AEDs were considered to be correct from the results of follow-up. We could not specify any AEDs that related to the appearance of ABPE. Conclusions: The selection of AED in this series was considered to be most appropriate. We proposed a criterion to determine whether to begin the AED treatment immediately at the initial seizure.
AB - Purpose: A retrospective study was carried out on 53 cases with childhood epilepsy to evaluate the validity of the initial selection of antiepileptic drug (AED). Methods: We investigated the AEDs selected at the beginning of the treatment from the medical records of 53 untreated cases. A follow-up study was undertaken to evaluate the effects of the AEDs. In the second study, we investigated the AEDs of 10 cases with atypical benign partial epilepsy (ABPE), to clarify whether the initial AEDs selected for rolandic epilepsy were related to the appearance of ABPE. Results: The AEDs used at the initial stage consisted of carbamazepine (CBZ), valproic acid (VPA), phenobarbital (PB), and vitamin B6. The main AEDs were CBZ and VPA for localization-related epilepsy, and VPA for generalized epilepsy. The initial selection of AEDs in 41 (85.4%) of 48 cases treated with AEDs were considered to be correct from the results of follow-up. We could not specify any AEDs that related to the appearance of ABPE. Conclusions: The selection of AED in this series was considered to be most appropriate. We proposed a criterion to determine whether to begin the AED treatment immediately at the initial seizure.
KW - Antiepileptic drugs
KW - Beginning of treatment
KW - Childhood epilepsy
KW - Initial seizure
KW - Medication
UR - http://www.scopus.com/inward/record.url?scp=10644297076&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=10644297076&partnerID=8YFLogxK
U2 - 10.1111/j.0013-9580.2004.458004.x
DO - 10.1111/j.0013-9580.2004.458004.x
M3 - Article
C2 - 15610189
AN - SCOPUS:10644297076
SN - 0013-9580
VL - 45
SP - 17
EP - 19
JO - Epilepsia
JF - Epilepsia
IS - SUPPL. 8
ER -