Initial cyclosporin A but not glucocorticoid treatment promotes recovery of striatal dopamine concentration in 6-hydroxydopamine lesioned mice

Kouji Matsuura; Hideaki Kabuto; Hirofumi Makino; Norio Ogawa

doi:10.1016/S0304-3940(97)00515-6

Initial cyclosporin A but not glucocorticoid treatment promotes recovery of striatal dopamine concentration in 6-hydroxydopamine lesioned mice

Kouji Matsuura, Hideaki Kabuto, Hirofumi Makino, Norio Ogawa

Research output: Contribution to journal › Article › peer-review

16 Citations (Scopus)

Abstract

We examined the effects of cyclosporin A (CsA) and glucocorticoid (GC; hydrocortisone sodium succinate) in a mouse model of experimental parkisonism. GC or CsA was administered 30 or 60 min, respectively, prior to intracerebroventricular injection of 6-hydroxydopamine, followed by injection of a similar dose of each drug 3 h later. CsA reduced the extent of depletion of striatal concentrations of dopamine (DA) and dihydroxyphenylacetic acid (DOPAC) associated with dopaminergic neuronal degeneration. GC reduced the extent of homovanillic acid (HVA) depletion in the same region. A combination treatment with CsA and GC did not produce a further enhancement of the recovery of striatal concentrations of monoamines observed with CsA only. Our findings demonstrated the beneficial effects of initial CsA treatment in experimental models of parkinsonism and further support the usefulness of CsA in the treatment of Parkinson's disease.

Original language	English
Pages (from-to)	191-194
Number of pages	4
Journal	Neuroscience Letters
Volume	230
Issue number	3
DOIs	https://doi.org/10.1016/S0304-3940(97)00515-6
Publication status	Published - Jul 25 1997

Keywords

6-Hydroxydopamine
Combination treatment
Glucocorticoid
Initial cyclosporin A treatment
Monoamine concentration
Parkinson's disease

ASJC Scopus subject areas

Neuroscience(all)

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title = "Initial cyclosporin A but not glucocorticoid treatment promotes recovery of striatal dopamine concentration in 6-hydroxydopamine lesioned mice",

abstract = "We examined the effects of cyclosporin A (CsA) and glucocorticoid (GC; hydrocortisone sodium succinate) in a mouse model of experimental parkisonism. GC or CsA was administered 30 or 60 min, respectively, prior to intracerebroventricular injection of 6-hydroxydopamine, followed by injection of a similar dose of each drug 3 h later. CsA reduced the extent of depletion of striatal concentrations of dopamine (DA) and dihydroxyphenylacetic acid (DOPAC) associated with dopaminergic neuronal degeneration. GC reduced the extent of homovanillic acid (HVA) depletion in the same region. A combination treatment with CsA and GC did not produce a further enhancement of the recovery of striatal concentrations of monoamines observed with CsA only. Our findings demonstrated the beneficial effects of initial CsA treatment in experimental models of parkinsonism and further support the usefulness of CsA in the treatment of Parkinson's disease.",

keywords = "6-Hydroxydopamine, Combination treatment, Glucocorticoid, Initial cyclosporin A treatment, Monoamine concentration, Parkinson's disease",

author = "Kouji Matsuura and Hideaki Kabuto and Hirofumi Makino and Norio Ogawa",

note = "Funding Information: This work was supported in part by Grants-in-Aid for Scientific Research on Priority Areas and Scientific Research from the Japanese Ministry of Education, Science, Sports and Culture, and by Grants-in-Aid for the Research Committee on CNS degenerative diseases and Research Projects on Aging and Health from the Japanese Ministry of Health and Welfare.",

year = "1997",

month = jul,

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doi = "10.1016/S0304-3940(97)00515-6",

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pages = "191--194",

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T1 - Initial cyclosporin A but not glucocorticoid treatment promotes recovery of striatal dopamine concentration in 6-hydroxydopamine lesioned mice

AU - Matsuura, Kouji

AU - Kabuto, Hideaki

AU - Makino, Hirofumi

AU - Ogawa, Norio

N1 - Funding Information: This work was supported in part by Grants-in-Aid for Scientific Research on Priority Areas and Scientific Research from the Japanese Ministry of Education, Science, Sports and Culture, and by Grants-in-Aid for the Research Committee on CNS degenerative diseases and Research Projects on Aging and Health from the Japanese Ministry of Health and Welfare.

PY - 1997/7/25

Y1 - 1997/7/25

N2 - We examined the effects of cyclosporin A (CsA) and glucocorticoid (GC; hydrocortisone sodium succinate) in a mouse model of experimental parkisonism. GC or CsA was administered 30 or 60 min, respectively, prior to intracerebroventricular injection of 6-hydroxydopamine, followed by injection of a similar dose of each drug 3 h later. CsA reduced the extent of depletion of striatal concentrations of dopamine (DA) and dihydroxyphenylacetic acid (DOPAC) associated with dopaminergic neuronal degeneration. GC reduced the extent of homovanillic acid (HVA) depletion in the same region. A combination treatment with CsA and GC did not produce a further enhancement of the recovery of striatal concentrations of monoamines observed with CsA only. Our findings demonstrated the beneficial effects of initial CsA treatment in experimental models of parkinsonism and further support the usefulness of CsA in the treatment of Parkinson's disease.

AB - We examined the effects of cyclosporin A (CsA) and glucocorticoid (GC; hydrocortisone sodium succinate) in a mouse model of experimental parkisonism. GC or CsA was administered 30 or 60 min, respectively, prior to intracerebroventricular injection of 6-hydroxydopamine, followed by injection of a similar dose of each drug 3 h later. CsA reduced the extent of depletion of striatal concentrations of dopamine (DA) and dihydroxyphenylacetic acid (DOPAC) associated with dopaminergic neuronal degeneration. GC reduced the extent of homovanillic acid (HVA) depletion in the same region. A combination treatment with CsA and GC did not produce a further enhancement of the recovery of striatal concentrations of monoamines observed with CsA only. Our findings demonstrated the beneficial effects of initial CsA treatment in experimental models of parkinsonism and further support the usefulness of CsA in the treatment of Parkinson's disease.

KW - 6-Hydroxydopamine

KW - Combination treatment

KW - Glucocorticoid

KW - Initial cyclosporin A treatment

KW - Monoamine concentration

KW - Parkinson's disease

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