Inhibitory effects of zingerone, a pungent component of Zingiber officinale Roscoe, on colonic motility in rats

Momoe Iwami, Takahiko Shiina, Haruko Ogawa, Takeshi Shima, Tadashi Takewaki, Yasutake Shimizu

Research output: Contribution to journalArticle

28 Citations (Scopus)

Abstract

Ginger (rhizome of Zingiber officinale Roscoe) is an herbal medicine for the treatment of gastrointestinal disorders including constipation and diarrhea. Zingerone is a likely active constituent responsible for the antidiarrheal activity of ginger. The current study was designed to characterize pharmacological actions of zingerone on colonic motility. To evaluate pharmacological effects of zingerone on colonic motility, we used isolated colonic segments from rats, in which mechanical responses were recorded in the longitudinal direction. In addition, we evaluated the effects on colonic motility in vivo by measuring intraluminal pressure changes and expelled fluid volume from the colon in anesthetized rats. Zingerone was applied to the lumen of the colon to allow the drug to access from the mucosal side. Zingerone inhibited spontaneous contractile movements in the isolated colonic segments in a dose-dependent manner. The inhibitory effects of zingerone on colonic movements were not affected by pretreatment with capsazepine, a typical antagonist of transient receptor potential vanilloid 1. In addition, tetrodotoxin, a blocker of voltage-dependent sodium channels on neurons, did not affect the suppression of colonic movements by zingerone, suggesting that zingerone acts on the smooth muscles directly. Zingerone also attenuated colonic motility in vivo without affecting blood pressure and heart rate. The effects were reversible and reproducible. Our findings suggest that zingerone can inhibit colonic motility via direct action on smooth muscles. Zingerone might exert beneficial therapeutic effects on hypermotility-induced diarrhea by abrogating excessive gastrointestinal motility.

Original languageEnglish
Pages (from-to)89-94
Number of pages6
JournalJournal of Natural Medicines
Volume65
Issue number1
DOIs
Publication statusPublished - Jan 2011
Externally publishedYes

Fingerprint

Ginger
Rats
Smooth Muscle
Muscle
Diarrhea
Colon
zingerone
Pharmacology
Antidiarrheals
Rhizome
Gastrointestinal Motility
Herbal Medicine
Sodium Channels
Blood pressure
Tetrodotoxin
Therapeutic Uses
Constipation
Neurons
Heart Rate

Keywords

  • Colon
  • Diarrhea
  • Gastrointestinal motility
  • Ginger
  • Zingerone

ASJC Scopus subject areas

  • Organic Chemistry
  • Drug Discovery
  • Pharmaceutical Science
  • Complementary and alternative medicine

Cite this

Inhibitory effects of zingerone, a pungent component of Zingiber officinale Roscoe, on colonic motility in rats. / Iwami, Momoe; Shiina, Takahiko; Ogawa, Haruko; Shima, Takeshi; Takewaki, Tadashi; Shimizu, Yasutake.

In: Journal of Natural Medicines, Vol. 65, No. 1, 01.2011, p. 89-94.

Research output: Contribution to journalArticle

Iwami, Momoe ; Shiina, Takahiko ; Ogawa, Haruko ; Shima, Takeshi ; Takewaki, Tadashi ; Shimizu, Yasutake. / Inhibitory effects of zingerone, a pungent component of Zingiber officinale Roscoe, on colonic motility in rats. In: Journal of Natural Medicines. 2011 ; Vol. 65, No. 1. pp. 89-94.
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